Prevalence and Determinants of Hyperuricemia in Middle-Aged, Urban Chinese Men

Abstract

Background: Hyperuricemia is associated with metabolic syndrome and has emerged as a marker for both type 2 diabetes and cardiovascular disease. We estimated the prevalence and lifestyle risk factors of hyperuricemia in middle-aged, urban Chinese men. Methods: The study included 3,978 urban Chinese men 40-74 years of age from a population-based cohort study, the Shanghai Men's Health Study, who were free of type 2 diabetes at baseline and had provided fasting blood samples. Uric acid concentrations were measured by the uricase method. Hyperuricemia was defi ned as >7.0 mg/dL. Anthropometric measurements and information on lifestyle factors and disease history were collected by in-person interviews. Results: One quarter of the study subjects had hyperuricemia. Participants with metabolic syndrome had a higher prevalence of hyperuricemia. Body mass index (BMI), waist-to-hip ratio (WHR), waist circumference, and weight gain (since age 20) were positively associated with the prevalence of hyperuricemia. Physical activity was inversely related to the prevalence of hyperuricemia. The odds ratios for hyperuricemia for quintiles of nonoccupational physical activity were 1.00, 0.80, 0.73, 0.75, and 0.57 ( P trend <0.001). Participants with hyperuricemia were less likely to be current smokers, but were more likely to drink alcohol regularly. Beer consumption was associated with higher risk of hyperuricemia compared with consumption of wine or liquor. Conclusions: In this representative sample of middle-aged, urban Chinese men, hyperuricemia is highly prevalent. Obesity, weight gain in adulthood, and alcohol intake were associated with a higher prevalence of hyperuricemia, whereas daily physical activity and smoking were inversely related to the prevalence of hyperuricemia.

Clinical Characteristics of Young-Onset Ischemic Colitis

“…However, it has been reported that physical activity is inversely related to the prevalence of hyperuricemia [49]. As moderate intense physical activity may also be associated with lower uric acid concentrations in obese individuals [50], further studies are needed to clarify the relationship between physical activity and IC development in the young population.…”

Prevalence of Hyperuricemia and the Relationship between Serum Uric Acid and Metabolic Syndrome in the Asian Mongolian Area

“…We further separated the participants according [30][31][32] , where the intake of purine-rich marine products is dominant, contributing to hyperuricemia and possibly MetS. In contrast, many studies [32][33][34][35][36][37] have found that an elevated SUA level is associated not only with purine intake from seafood, meat and beer, but also the presence of endogenous metabolic disorders.…”

No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach

“…Of note, only a few studies corrected for alcohol consumption and smoking and hardly any studies corrected for renal function or use of diuretics, which are associated with diabetes and serum uric acid levels [32,33]. Further, physical activity may also confound the association and adequate correction is limited by imperfect measurement [34].…”