Prevalence and determinants of cognitive impairment in patients with chronic kidney disease: A cross-sectional study in Benin City, Nigeria

Egbi, Oghenekaro Godwin; Ogunrin, Olubunmi; Oviasu, E

doi:10.4103/1596-3519.149877

Cited by 16 publications

(33 citation statements)

References 27 publications

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“…These authors explained that high risk of cardiovascular and cerebrovascular diseases can increase risk cognitive impairment in patients with impaired kidney function [6][7][8][9][10][11]. Additionally, many conditions such as anemia, hypoproteinemia, and oxidative stress, may link CKD with reduced cognitive function [12,13]. Furthermore, accumulative evidence has also demonstrated that the association remains unchanged even after controlling for cardiovascular and cerebrovascular diseases, suggesting that reduced kidney function may be an independent risk factor for cognitive impairment, although their mechanism is still unclear.…”

Section: Introductionmentioning

confidence: 99%

Kidney Function and Cognitive Impairment in People Aged 80 Years and Over with Untreated Hypertension: A Cross-Sectional Survey

Wang

Liu

Cai

et al. 2016

Kidney Blood Press Res

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Background/Aims: Both kidney dysfunction and cognitive impairment are common problems in hypertensive patients. However, few studies have explored the association between these conditions in hypertensive patients aged 80 or over. The current study was undertaken to determine the impact of chronic kidney disease (CKD) and estimated glomerular filtration rate (eGFR) on cognitive impairment among an 80-year-old population with untreated hypertension in China. Methods: A total of 395 hypertensive patients aged 80 or over were assessed for the presence of cognitive impairment according to the 30-item Mini-Mental State Examination (MMSE). Cognitive impairment was defined as a score below 24 on MMSE. eGFR was evaluated using the Chinese Modification of Diet in Renal Disease equation. CKD was defined according to categorical approach, which is based on “YES” (eGFR below 60 ml/min) or “NO” (eGFR above 60 ml/min). Results: The mean (SD) age was 83.0 ± 2.6 years for the sample, of whom 69.8% were female. There were 59 (14.9%) and 280 (71.1%) prevalent cases of CKD and cognitive impairment, respectively. CKD patients were older, had higher scores on Activity of Daily Living (ADL), and lower score on MMSE. After controlling for potential confounding, multiple logistic regressions demonstrated that both CKD and eGFR were associated with cognitive impairment in hypertensive patients aged 80 or over. Conclusion: Our study found that both CKD and eGFR were associated with cognitive impairment among hypertensive patients aged 80 or over in China. Therefore, targeted screening for cognitive impairment should be considered in these patients with CKD.

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Section: Introductionmentioning

confidence: 99%

Kidney Function and Cognitive Impairment in People Aged 80 Years and Over with Untreated Hypertension: A Cross-Sectional Survey

Wang

Liu

Cai

et al. 2016

Kidney Blood Press Res

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“…A graded relationship has been found between eGFR and cognition, with each 10 ml/min per 1.73 m 2 decline in eGFR being associated with 11% higher prevalence of cognitive impairment (14). Few studies have evaluated the risk conferred by low serum bicarbonate on cognitive function, with mixed results (17,18).…”

Section: Introductionmentioning

confidence: 99%

Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults

Dobre¹,

Gaussoin²,

Bates³

et al. 2018

CJASN

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“…[1] This study was designed with the aim to determine the prevalence and the find out the determinants of cognitive impairment among CKD patients in Nigeria. The authors, at the end of the study, conclude that the CKD is associated with significant cord injury in Nigerian patients, especially with progressive deterioration in renal function.…”

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confidence: 99%

“…The authors, at the end of the study, conclude that the CKD is associated with significant cord injury in Nigerian patients, especially with progressive deterioration in renal function. [1] Authors deserve appreciation for their effort. However, I have some concerns with this study.…”

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Matching in hospital based case-control studies

Raina

2016

Ann Afr Med

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Prevalence and determinants of cognitive impairment in patients with chronic kidney disease: A cross-sectional study in Benin City, Nigeria

Abstract: CKD is associated with significant CI in Nigerian patients especially with progressive deterioration in renal function. There is a need for regular evaluation of CKD patients for cognitive deficits.

Cited by 16 publications

References 27 publications

Kidney Function and Cognitive Impairment in People Aged 80 Years and Over with Untreated Hypertension: A Cross-Sectional Survey

Kidney Function and Cognitive Impairment in People Aged 80 Years and Over with Untreated Hypertension: A Cross-Sectional Survey

Serum Bicarbonate Concentration and Cognitive Function in Hypertensive Adults

Matching in hospital based case-control studies

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