Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes

Kim, Tae Nyun; Park, Man Sik; Yang, Sae Jeong; Yoo, Hye Jin; Kang, Hyun Joo; Song, Wook; Seo, Ji A; Kim, Sin Gon; Kim, Nan Hee; Baik, Sei Hyun; Choi, Dong Seop; Choi, Kyung Mook

doi:10.2337/dc09-2310

Cited by 504 publications

(434 citation statements)

References 12 publications

(15 reference statements)

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“…The pathophysiology of muscle wasting in patients with chronic diseases is not entirely clear yet. Signaling pathways may be different in healthy aging and in patients with chronic diseases with higher inflammatory load and thus more pronounced proteasome activity in patients with chronic disease, thus serving as a basis for active myofibril degeneration (34,39). Indeed, one of the hypotheses holds that inflammatory processes, which accompany many chronic diseases, may lead to metabolic changes.…”

Section: Discussionmentioning

confidence: 99%

Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life

Bekfani

Pellicori

Morris

et al. 2016

International Journal of Cardiology

192

152

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Bekfani, T. et al. (2016) Sarcopenia in patients with heart failure with preserved ejection fraction: impact on muscle strength, exercise capacity and quality of life. International Journal of Cardiology, 222, pp. 41-46. (doi:10.1016Cardiology, 222, pp. 41-46. (doi:10. /j.ijcard.2016 This is the author's final accepted version.There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/129510/ AbstractBackground: To describe the prevalence of sarcopenia in ambulatory patients with heart failure with preserved ejection fraction (HFpEF) and its relation to reduced exercise capacity, muscle strength, and quality of life (QoL). Methods and Results:A total of 117 symptomatic outpatients with HFpEF were prospectively enrolled in Germany, England, and Slovenia as part of the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF). Appendicular skeletal muscle (ASM) mass (the sum of muscle mass in both arms and legs) was assessed by DEXA.Echocardiography, 6-minute walk testing (6-MWT), muscle strength assessment, spiroergometry and QoL evaluation using EQ-5D Questionnaire were performed. Sarcopenia was defined as ASM 2 standard deviations below the mean of a healthy reference group aged 18-40 years. Patients were divided into 3 groups according to the E/e' value: ≤8, 9-14, and ≥15. Sarcopenia was detected in 19.7% of all patients. These patients performed worse during 6-MWT (404±116 vs. 307±145 meters, p=0.003) and showed lower absolute peak oxygen consumption (1579±474 vs. 1211±442 ml/min, P<0.05). Both ASM and muscle strength were lowest in patients with E/e'>15 (P<0.05). Higher values of muscle strength/ASM were associated with a better QoL (r=0.5, p<0.0005). Logistic regression showed ASM to be independently associated with reduced distance walked during the 6-MWT adjusted for NYHA, height, left atrium diameter, ferritin and forced expiratory volume in 1 second (FEV1) (odds ratio 1.2, p=0.02). Conclusion:Sarcopenia affects a clinically relevant proportion of patients with HFpEF. Low ASM is strongly linked to reduced muscle strength, exercise capacity and QoL in these patients. 4 KeywordsHeart failure with preserved ejection fraction -muscle wasting -sarcopenia -exercise capacity -quality of life.5

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Section: Discussionmentioning

confidence: 99%

Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life

Bekfani

Pellicori

Morris

et al. 2016

International Journal of Cardiology

192

152

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“…Typically, people with sarcopenic obesity have visceral fat accumulation [58], a well-known risk factor for cardiovascular mortality [46]. The prevalence of sarcopenic obesity has been reported to be higher in type 2 diabetes compared with non-diabetes (15.7% vs 6.9% respectively in the Korean Sarcopenic Obesity Study) [59] and it has also been linked to an increased risk of falls [59], physical disability [60] and cardiovascular and all-cause mortality [61][62][63][64]. Another possible explanation could be reverse causation.…”

Section: Discussionmentioning

confidence: 99%

Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies

et al. 2016

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Aims/hypothesis The relationship between BMI and mortality has been extensively investigated in the general population; however, it is less clear in people with type 2 diabetes. We aimed to assess the association of BMI with all-cause and cardiovascular mortality in individuals with type 2 diabetes mellitus. Methods We searched electronic databases up to 1 March 2016 for prospective studies reporting associations for three or more BMI groups with all-cause and cardiovascular mortality in individuals with type 2 diabetes mellitus. Study-specific associations between BMI and the most-adjusted RR were estimated using restricted cubic splines and a generalised least squares method before pooling study estimates with a multivariate random-effects meta-analysis. Results We included 21 studies including 24 cohorts, 414,587 participants, 61,889 all-cause and 4470 cardiovascular incident deaths; follow-up ranged from 2.7 to 15.9 years. There was a strong nonlinear relationship between BMI and all-cause mortality in both men and women, with the lowest estimated risk from 31-35 kg/m 2 and 28-31 kg/m 2 (p value for nonlinearity <0.001) respectively. The risk of mortality at higher BMI values increased significantly only in women, whilst lower values were associated with higher mortality in both sexes. Limited data for cardiovascular mortality were available, with a possible inverse linear association with BMI (higher risk for BMI <27 kg/m 2 ). Conclusions/interpretation In type 2 diabetes, BMI is nonlinearly associated with all-cause mortality with lowest risk in the overweight group in both men and women. Further research is needed to clarify the relationship with cardiovascular mortality and assess causality and sex differences.

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“…In addition to the impairment of functional capacity 4 , there are other health consequences related to sarcopenic obesity. One of these effects is an increased risk of developing type 2 diabetes mellitus 5 , increased levels of triglycerides, metabolic syndrome and cardiovascular disease [6][7][8] . Many times, the cause of sarcopenia, as well as obesity, is multifactorial.…”

Section: Introductionmentioning

confidence: 99%

“…Aging is typically the major cause; however, other factors may interfere with the development of this condition. These factors may include sedentary lifestyle, low consumption and absorption of nutrients, low levels of vitamin D, use of medications that cause anorexia and smoking 2,5 . Sedentary lifestyle is an important risk factor related to weight gain and the decrease in SMM 10 .…”

Section: Introductionmentioning

confidence: 99%

Longer time after bariatric surgery and sedentary leisure modify anthropometric parameters, body composition and sarcopenic obesity markers in women

Hintze

Silva

Bianchini

et al. 2017

Rev. Bras. Ativ. Fís. Saúde

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Sarcopenic Obesity is known as a decrease in the quantity and quality of the skeletal muscle mass and increase in fat mass. It can be measured by the residual appendicular skeletal muscle mass (Ap SMM) based on the difference between actual and predicted values. Even though this condition is more common among sedentary elderlies, it may be present in subjects who underwent Bariatric Surgery (BS). We aimed to evaluate the influence of time after BS and physical activity level (PAL) during leisure time on anthropometric parameters, body composition and sarcopenic obesity markers in women. It is a cross-sectional study involving 42 women divided into two groups according to the time since BS and two groups according to PAL. Anthropometric variables, body composition, and sarcopenic obesity markers were assessed. The variables appendicular skeletal muscle mass, height, and fat mass were used to determine sarcopenic obesity markers. Non-parametric numerical tests were used for group comparison and significance level was set at p<0.05. Considering women with sedentary leisure only, those with longer time after BS had higher current body weight and BMI, waist and hip circumference, fat mass, fat-free mass, Ap SMM (equation, residual, and relative) (p<0.05). Considering women with longer time after BS only, sedentary ones had higher current body weight and BMI, waist circumference, fat mass, fat-free mass (relative only), Ap SMM (equation and relative) (p<0.05). Our data indicate that longer time after BS and sedentary leisure modify anthropometric parameters, body composition and sarcopenic obesity markers in women. KeywordsBariatric Surgery; Body Composition; Sarcopenia; Motor Activity; Obesity. Resumo A Obesidade Sarcopênica é associada à diminuição da quantidade e qualidade da massa muscular esquelética e pelo aumento na massa gorda. Ela pode ser medida pela massa muscular esquelética apendicular (Ap MME) baseada na diferença entre os valores reais e preditos. Mesmo sendo mais comum em idosos sedentários, esta condição pode ser verificada em indivíduos submetidos à Cirurgia Bariátrica (CB). O objetivo do estudo foi avaliar a influência do tempo de CB e nível de actividade física (NAF) durante o lazer em parâmetros antropométri

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Prevalence and Determinant Factors of Sarcopenia in Patients With Type 2 Diabetes

Cited by 504 publications

References 12 publications

Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life

Sarcopenia in patients with heart failure with preserved ejection fraction: Impact on muscle strength, exercise capacity and quality of life

Nonlinear association of BMI with all-cause and cardiovascular mortality in type 2 diabetes mellitus: a systematic review and meta-analysis of 414,587 participants in prospective studies

Longer time after bariatric surgery and sedentary leisure modify anthropometric parameters, body composition and sarcopenic obesity markers in women

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