Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma

AlQudah, Mohammad; Al-Shaikh, Ala’a; Haddad, Husam K.; Elhassan, Mohammad; Elhassan, Osman Basheir; Dababneh, Melad; Zaitoun, Anas Wasef; Ghamdi, Nawwaf Saleh Al; Al-Najjar, Bara'a Yousef

doi:10.1007/s12105-020-01150-2

Cited by 5 publications

(6 citation statements)

References 27 publications

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“…Recently, Khasawneh et al (2020) [134] reported 31% HPV positivity in head and neck squamous cell carcinoma samples, of which 42%, 37%, and 18% of HPV positivity was present in samples from the oropharynx, oral cavity, and larynx, respectively. On the other hand, while a study on laryngeal squamous cell carcinoma found 15.4% of the samples positive for HPV [135], another investigation focusing on both oral and laryngeal squamous cell carcinomas demonstrated an overall pooled HPV positivity of 15%; compared with laryngeal carcinoma, oral carcinomas exhibited a higher HPV positivity (6% vs. 20%) [152]. Nevertheless, all three studies reported predominance of the HPV16 genotype in their samples (31-85%) [134,135,152].…”

Section: In Levant Countriesmentioning

confidence: 99%

“…On the other hand, while a study on laryngeal squamous cell carcinoma found 15.4% of the samples positive for HPV [135], another investigation focusing on both oral and laryngeal squamous cell carcinomas demonstrated an overall pooled HPV positivity of 15%; compared with laryngeal carcinoma, oral carcinomas exhibited a higher HPV positivity (6% vs. 20%) [152]. Nevertheless, all three studies reported predominance of the HPV16 genotype in their samples (31-85%) [134,135,152].…”

Section: In Levant Countriesmentioning

confidence: 99%

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Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

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The human papillomavirus (HPV) is a non-enveloped double-stranded DNA virus capable of infecting skin and mucosa epithelial cells. Commonly, HPV infection is associated with sexually transmitted diseases and is considered the leading cause of cervical cancer and other carcinomas of the anogenital tract. However, several studies reported their involvement in cancers of non-sexual regions, including colorectal, head and neck, and breast cancers. There are several studies from the Middle East and North Africa (MENA) regions on the potential association between high-risk HPVs and cancer; nevertheless, there are limited studies that address the significance of HPV vaccination as a potential guard against these cancers. In the current review, we present a comprehensive description of the current HPV-associated cancers prevalence rates in the MENA region, demonstrating their steady increase with time, especially in African regions. Moreover, we discuss the potential impact of vaccination against HPV infections and its outcome on human health in this region.

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Section: In Levant Countriesmentioning

confidence: 99%

Section: In Levant Countriesmentioning

confidence: 99%

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

et al. 2022

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“…In most cases, HPV -positive tumors manifest as moderately differentiated SCC. HPV -positive LCs are more likely to be associated with higher histological scores compared to HPV -negative cases ( 46 ). HPV may be a more important cause of LC in women ( 47 ).…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review

Igissin,

Zatonskikh,

Telmanova

et al. 2023

ijph

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Laryngeal cancer comprises 30%-40% of head and neck malignancies, and it is the most common malignancy in otolaryngology. The main risk factors for laryngeal cancer are tobacco use, excessive alcohol consumption, gastroesophageal reflex, Plummer-Vinson syndrome, exposure to heat, chemicals, and some viral infections. This literature review summarizes all known data over the past decade with an assessment of the main etiological factors related to cancer incidence, general measurement issues in the cancer epidemiology and the current state of science in relation to laryngeal cancer. The geographical distribution of laryngeal cancer also reveals some important aspects. Europe remains the most prevalent continent for this type of malignancy, whilst the epidemiologic burden in Africa remains low. Overall, there are clear differences in morbidity and mortality from laryngeal cancer between urban and rural areas, with gender inequalities. In some countries, the incidence rates are high in rural areas, and in some, such as in China, the urban population is more affected. High rates of laryngeal cancer are closely associated with both low average income and a high percentage of the population with lower-than-average education countries with higher Socio-demographic Index (SDI) have made greater improvements in the treatment of LC than countries with lower SDI. Epidemiological data on risk factors can provide valuable information for developing cancer prevention strategies.

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“…However, unlike cervical carcinoma and oropharyngeal squamous cell carcinoma, the role of HPV 16/18 in the pathogenesis of laryngeal carcinoma has not been clearly defined [6,7]. The prevalence of HPV in laryngeal cancer shows wide variation within different zones of the same country [8,9]. Possible causes proposed are variations in demographic factors, tumor site, and method of virus detection.…”

Section: Introductionmentioning

confidence: 99%

High-Risk Human Papillomavirus Infection in Squamous Cell Carcinoma of the Larynx: A Study From a Tertiary Care Center in North India

Ghosh¹,

Kumar²,

Chaudhary³

et al. 2023

Cureus

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BackgroundHuman papillomavirus (HPV) 16/18 infection has been considered as an important etiological factor for laryngeal carcinoma. Considering its impact on prognosis, it is important to understand the true prevalence of HPV-associated laryngeal squamous cell carcinoma (LSCC) in the northeast region of India. Materials and methodsA prospective observational study was conducted among patients with laryngeal squamous cell carcinoma in the department of otolaryngology of King George's Medical University (KGMU), Lucknow. ResultsIn this study, the total number of cases was 62. HPV 16/18 positivity was higher (p=0.02) among the age group 31-40 years (40%) as compared to above 50 years (3.3%). HPV positivity was higher among females (50%) as compared to males (12.5%). Out of 34 tobacco smokers, HPV positivity was seen in 20.6% as compared to no positivity among patients without any history of addiction.HPV positivity was found in 19.6% of supraglottic cancer and no positivity among glottic cancer. HPV positivity was higher among the T1 stage of supraglottic carcinoma (40%) as compared to T3 (17.4%). In glottic cases, HPV positivity was nil in all T stages. ConclusionThe association of tumor HPV status with laryngeal squamous cell carcinoma in females and young patients (<50 years) observed in our study is consistent with prior studies, and this reflects that HPV status should be considered in the design or analysis for the treatment of laryngeal cancer. We tried to highlight the importance of diagnosing HPV-positive laryngeal squamous cell carcinoma at early stages of the disease and also added information about the prevalence of HPV-positive LSCC in this zone of the country. We have observed that laryngeal carcinoma from tobacco smokers contains transcriptionally active HPV and hence may act as a risk factor or act synergistically with HPV infection. Further studies with larger sample size are needed to clearly establish the association of HPV in laryngeal squamous cell carcinoma and its impact on disease prognosis.Categories: Otolaryngology, Pathology, Oncology Keywords: squamous cell carcinoma of the larynx, polymerase chain reaction (pcr), high-risk papillomavirus, head and neck oncology, smoking tobacco, pcr (polymerase chain reaction)

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Prevalence and Detection of Sexually Transmitted Cases of Laryngeal Carcinoma

Cited by 5 publications

References 27 publications

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

Human Papillomaviruses-Related Cancers: An Update on the Presence and Prevention Strategies in the Middle East and North African Regions

Laryngeal Cancer: Epidemiology, Etiology, and Prevention: A Narrative Review

High-Risk Human Papillomavirus Infection in Squamous Cell Carcinoma of the Larynx: A Study From a Tertiary Care Center in North India

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