S troke is the third leading cause of death in high-income countries, and accounts for substantial morbidity in those who survive. 1 Ischemic stroke is primarily due to a thrombotic or embolic event, and emboli frequently originate in the heart. 2 Transthoracic echocardiography can sometimes diagnose cardiac sources of embolism, such as atrial or ventricular thrombus, 3-5 and these generally require anticoagulation. Transthoracic echocardiography can also identify other causes of stroke that may require intervention, such as atrial abnormalities (e.g., patent foramen ovale, atrial myxoma) 6-8 or infective endocarditis. Transthoracic echocardiography is often recommended to plan secondary stroke management, but it is unclear how often this test provides clinically actionable findings. 4,9 Previous studies provide a range of conflicting estimates for how often transthoracic echocardiography might affect patient management because of changing opinions on what pathology is considered clinically relevant. 10,11 For example, dilated cardiomyopathy is no longer an indication for anticoagulation among patients with stroke. 12 Other findings previously considered to be incidental, such as patent foramen ovale, are now clinically actionable among patients with cryptogenic stroke. 6-8 Current stroke clinical practice guidelines do not reflect these nuanced data, making it challenging for physicians to know which patients should have transthoracic echocardiography after an ischemic stroke. 9,13,14 Furthermore, data that are both comprehensive and recent are lacking to further understanding of how often patients in routine care with stroke will have echocardiographic findings that are clinically actionable. Choosing Wisely 15 advocates against routine low-value care that is unlikely to improve patient care or is likely to cause harm. Transthoracic echocardiography is unlikely to cause direct patient harm but may cause indirect harm; for example, where incidental findings lead to invasive testing (i.e., transesophageal echocardiography) and expose patients to additional risks. Awaiting transthoracic echocardiography can also RESEARCH HEALTH SERVICES