Prevalence and correlates of vitamin D deficiency in US adults

Forrest, Kimberly Y.‐Z.; Stuhldreher, Wendy L.

doi:10.1016/j.nutres.2010.12.001

Cited by 816 publications

(625 citation statements)

References 44 publications

Supporting

Mentioning

523

Contrasting

Unclassified

Order By: Relevance

“…Ozkan et al [69] reported that black patients had lower FF vitamin D levels than nonblack patients (18.88±8.5 ng/mL versus 30.51± 12.95 ng/mL, p=0.001). This finding of lower vitamin D levels in blacks is consistent with previous findings in a noninfertile population [5]. The first Rudick et al [70] study reported Hispanic whites as having significantly lower serum vitamin D levels than Asians or non-Hispanic whites (p= 0.01).…”

Section: Vitamin D and Patient Demographicssupporting

confidence: 89%

“…Data from the National Health and Nutrition Examination Surveys (NHANES) [4] found that risk varied between racial and ethnic groups, with non-Hispanic blacks demonstrating a higher prevalence of vitamin D deficiency and inadequacy as compared to their white counterparts. These findings were echoed by Forrest et al [5], who found that blacks had the highest rate of vitamin D deficiency (82.1 %), followed by Hispanics (69.2 %). Despite its prevalence, universal screening for vitamin D deficiency has not been promoted due to the high cost of serum assays.…”

Section: Epidemiology Of Vitamin D Deficiencymentioning

confidence: 86%

See 1 more Smart Citation

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To review the current literature regarding the role of vitamin D status in pregnancy outcomes in women undergoing assisted reproductive technology (ART) and to assess cost-effectiveness of routine vitamin D deficiency screening and repletion prior to initiation of ART.Methods A systematic literature review was conducted using PubMed. Relevant study outcomes were compared among the selected studies. A cost-benefit analysis was performed using a decision tree mathematical model with sensitivity analyses from the perspective of direct societal cost. Published data were used to estimate probabilities and costs in 2014 US dollars. Results Thirty-four articles were retrieved, of which eight met inclusion criteria. One study demonstrated a negative relationship between vitamin D status and ART outcomes, while two studies showed no association. The remaining five studies concluded that ART outcomes improved after vitamin D repletion. Conclusion The majority of reviewed studies reported a decrement in ART outcomes in patients with vitamin D deficiency. Cost-benefit analyses suggested that screening and supplementing vitamin D prior to ART might be cost effective, but further evidence is needed. Given the absence of Level I evidence regarding vitamin D status and ART outcomes, full endorsement of routine vitamin D screening and supplementation prior to ART is premature.

show abstract

Section: Vitamin D and Patient Demographicssupporting

confidence: 89%

Section: Epidemiology Of Vitamin D Deficiencymentioning

confidence: 86%

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Pacis

Fortin

Zarek

et al. 2014

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .…”

Section: -Hydroxycholecaliferol Parathyroid Hormone Serum Lipids Elmentioning

confidence: 99%

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Jungert

Roth²,

Neuhäuser‐Berthold

2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Although emerging evidence indicates an association between vitamin D and serum lipids, the data are still inconsistent. The purpose of the present study was to investigate whether 25-hydroxycholecalciferol (25-hydroxyvitamin D 3 ; 25(OH)D 3 ) or intact parathyroid hormone (iPTH) was independently related to serum lipids in elderly women and men. Design: Cross-sectional study. Fasting serum levels of 25(OH)D 3 , iPTH, TAG, total cholesterol (TC), HDL cholesterol (HDL-C) and LDL cholesterol (LDL-C) were assessed. Body composition was measured by bioelectrical impedance analysis. Lifestyle factors, such as nutrient intake, time spent outdoors, physical activity, smoking, supplement intake and medication, were assessed by questionnaires. Multiple regression analyses were performed to examine associations of 25(OH)D 3 and iPTH with serum lipids. Setting: Giessen, Germany. 25-Hydroxycholecaliferol Parathyroid hormone Serum lipids ElderlyAccumulating epidemiological data indicate that vitamin D deficiency may be accompanied by susceptibility for chronic diseases (1) . Recently, a low vitamin D status has been linked to increased serum levels of TAG, total cholesterol (TC) and LDL cholesterol (LDL-C), as well as low concentrations of HDL cholesterol (HDL-C) (2)(3)(4)(5)(6)(7)(8) . Parathyroid hormone (PTH), which increases in the presence of vitamin D insufficiency, was also linked to serum lipids (9) . However, the results are inconsistent and associations often vanished after controlling for confounding variables (5,6,8) .The question arises whether the assumed associations between serum lipids and vitamin D and PTH are independent from other cardiovascular risk factors like obesity, which has been associated with elevated serum lipids (10) and may also interfere with the vitamin D endocrine system (11) . In addition, the associations may differ by sex considering the differences in body composition and serum lipid levels between women and men. Previous studies were mostly performed on ambulatory patients and/or vitamin Ddeficient, middle-aged or overweight and obese individuals and often without adjustments for potential confounders, such as the association between vitamin D and PTH, body composition, medical conditions and/or lifestyle factors, including sun exposure, physical activity and habitual diet (4)(5)(6)(7)9,(12)(13)(14)(15) .As dyslipidaemia is an important CVD risk factor and an established component of the metabolic syndrome, treatment and prevention strategies are of particular importance (16) . This applies especially to elderly people, who are at risk of developing dyslipidaemia. Moreover, an advanced age is linked to vitamin D deficiency because of age-related declines in endogenous vitamin D synthesis, sun exposure

show abstract

“…Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .…”

mentioning

confidence: 99%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

View full text Add to dashboard Cite

Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Design: An intervention trial. Setting: Shenzhen City, Guangdong Province, China. Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.Results: For the survey, there was no significant difference (P > 0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P = 0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P < 0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men. Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. KeywordsVitamin D Obesity Chinese male Parathyroid hormone Insulin resistanceIn China, approximately 12 % of adult males are considered to be obese (1,2) . Since vitamin D nutritional status may be important in regulating obesity (3)(4)(5)(6) , interest was aroused to study Chinese obese males in this regard. Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .In addition, 25(OH)D ≤25 nmol/l (10 ng/ml) is considered to be 'severe vitamin D deficiency', 75-250 nmol/l (30-100 ng/ml) a 'sufficient or optimal' level and 50-75 nmol/l (21-29 ng/ml) an 'insufficient' level (12,13,18) , although these reference ranges are not defined by the Inst...

show abstract

Prevalence and correlates of vitamin D deficiency in US adults

Cited by 816 publications

References 44 publications

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Vitamin D and assisted reproduction: should vitamin D be routinely screened and repleted prior to ART? A systematic review

Associations of serum 25-hydroxycholecalciferol and parathyroid hormone with serum lipids differ by sex and vitamin D status

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Contact Info

Product

Resources

About