Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: the Korean Health and Genome Study

Shin, Chol; Abbott, Robert D.; Lee, H; Kim, J; Kimm, Kuchan

doi:10.1038/sj.jhh.1001732

Cited by 116 publications

(101 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Orthostatic hypotension (OH) is common in adults with hypertension1, 2, 3 and diabetes mellitus4 and is associated with several adverse health outcomes, including falls, syncope, and death 5. Although OH has been associated with change in heart structure over time, suggestive of a causal relationship,6 the association between OH and cardiovascular disease (CVD) in the literature is inconsistent.…”

mentioning

confidence: 99%

Orthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle‐Aged Adults

Juraschek

Daya

Appel

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundAlthough orthostatic hypotension (OH) is a well‐recognized manifestation of neuropathy and hypovolemia, its contribution to cardiovascular disease (CVD) risk is controversial.Methods and ResultsParticipants with OH, defined as a decrease in blood pressure (systolic ≥20 mm Hg or diastolic ≥10 mm Hg) from the supine to standing position, were identified during the first visit of the ARIC (Atherosclerosis Risk in Communities) Study (1987–1989) within 2 minutes of standing. All participants were followed up for the development of myocardial infarction, heart failure, stroke, fatal coronary heart disease (CHD), any CHD (combination of silent, nonfatal, and fatal CHD or cardiac procedures), and all‐cause mortality. Participants were assessed for carotid intimal thickness and plaque during the first visit. Detectable high‐sensitivity troponin T (≥5 ng/L) and elevated NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide; ≥100 pg/mL) were determined in blood collected during the second visit (1990–1992). All associations were adjusted for known CVD risk factors. In 9139 participants (57% women; 23% black; mean age, 54±5.7 years), 3% had OH. During follow‐up (median, 26 years), OH was associated with myocardial infarction (hazard ratio [HR], 1.88; 95% confidence interval [CI], 1.44–2.46), congestive heart failure (HR, 1.65; 95% CI, 1.34–2.04), stroke (HR, 1.83; 95% CI, 1.35–2.48), fatal CHD (HR, 2.77; 95% CI, 1.93–3.98), any CHD (HR, 2.00; 95% CI, 1.64–2.44), and all‐cause mortality (HR, 1.68; 95% CI, 1.45–1.95). OH was also associated with carotid intimal thickness (β, 0.05 mm; 95% CI, 0.04–0.07 mm), carotid plaque (odds ratio, 1.51; 95% CI, 1.18–1.93), detectable high‐sensitivity troponin T (odds ratio, 1.49; 95% CI, 1.16–1.93), and elevated NT‐proBNP (odds ratio, 1.92; 95% CI, 1.48–2.49).Conclusions OH identified in community‐dwelling middle‐aged adults was associated with future CVD events and subclinical CVD. Further research is necessary to establish a causal role for OH in the pathogenesis of CVD.

show abstract

mentioning

confidence: 99%

Orthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle‐Aged Adults

Juraschek

Daya

Appel

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…For this analysis, nine datasets from the DETECT-2 database were selected, which were representative of people from a diverse range of ethnic backgrounds (Northern and Southern Europe, U.S., Indian subcontinent, Asia, Australia, Pacific Islands, and Africa) (2,8,(21)(22)(23)(24)(25)(26)(27). For the Third National Health and Nutrition Examination Survey (NHANES III), only the subsample of individuals that underwent a 75-g oral glucose tolerance test was included (2).…”

Section: Research Design Andmentioning

confidence: 99%

Risk Scores for Type 2 Diabetes Can Be Applied in Some Populations but Not All

Vistisen²,

et al. 2006

View full text Add to dashboard Cite

OBJECTIVE -Risk scores based on phenotypic characteristics to identify individuals at high risk of having undiagnosed diabetes have been developed in Caucasian populations. The impact of known risk factors on having undiagnosed type 2 diabetes differs between populations from different ethnic origin, and risk scores developed in Caucasians may not be applicable to other ethnic groups. This study evaluated the performance of one risk score in nine populations of diverse ethnic origin.RESEARCH DESIGN AND METHODS -Data provided by centers from around the world to the DETECT-2 project were used. The database includes population-based surveys with information on at least 500 people without known diabetes having a 75-g oral glucose tolerance test. To date, 52 centers have contributed data on 190,000 individuals from 34 countries. In this analysis, nine cross-sectional studies were selected representing diverse ethnic and regional backgrounds. The risk score assessed uses information on age, sex, blood pressure treatment, and BMI.RESULTS -This analysis included 29,758 individuals; 1,805 individuals had undiagnosed diabetes. The performance of the risk score varied widely, with sensitivity, specificity, and percentage needing further testing ranging between 12 and 57%, 72 and 93%, and 2 and 25%, respectively, with the worse performance in non-Caucasian populations. This variation in performance was related to differences in the association between prevalence of undiagnosed diabetes and components of the risk score.CONCLUSIONS -A typical risk score developed in Caucasian populations cannot be applied to other populations of diverse ethnic origins. Diabetes Care 29:410 -414, 2006T ype 2 diabetes is a common and serious condition associated with reduced life expectancy and considerable morbidity. Recent estimates suggest that currently 195 million people throughout the world have diabetes, and this will increase to over 330 million by 2025 (1). Approximately 50% of people with diabetes are undiagnosed (2,3). Because type 2 diabetes may remain undetected for several years, at the time of clinical diagnosis, many people have one or more micro-or macrovascular complications (4).Detecting people with undiagnosed type 2 diabetes is important for both public health policy and everyday clinical practice. Because of the rapidly increasing prevalence of type 2 diabetes (5-8), screening individuals at high risk of having undiagnosed diabetes is recommended in several countries (9 -11). Several questionnaires have been developed to detect this high-risk group (12-17). They all perform equally well, with a sensitivity of 70 -75% and a specificity of 55-70%. Because the majority of risk scores have been developed and validated in Caucasians (12,18), their applicability to populations of different ethnic background and with different risk factor distribution is uncertain.The DETECT-2 project is an international data pooling collaboration specifically addressing issues related to screening for type 2 diabetes, with an emphasis on the imp...

show abstract

“…The KHGS is an ongoing prospective study involving a biennial examination; its methods have been previously described [20]. Eligibility criteria were based on age (40-69 years), residence within the borders of the survey area for at least 6 months, and mental and physical ability to participate.…”

Section: Study Populationmentioning

confidence: 99%

The relationship between body fat and C-reactive protein in middle-aged Korean population

et al. 2006

View full text Add to dashboard Cite

Prevalence and correlates of orthostatic hypotension in middle-aged men and women in Korea: the Korean Health and Genome Study

Cited by 116 publications

References 28 publications

Orthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle‐Aged Adults

Orthostatic Hypotension and Risk of Clinical and Subclinical Cardiovascular Disease in Middle‐Aged Adults

Risk Scores for Type 2 Diabetes Can Be Applied in Some Populations but Not All

The relationship between body fat and C-reactive protein in middle-aged Korean population

Contact Info

Product

Resources

About