Prevalence and correlates of major depressive disorder (MDD) among adolescent patients with epilepsy attending a Nigerian neuropsychiatric hospital

Fela-Thomas, Ayodele; Akinhanmi, Akinwande O.; Esan, Oluyomi

doi:10.1016/j.yebeh.2015.11.008

Cited by 11 publications

(11 citation statements)

References 50 publications

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“…Health care providers have reason to be concerned, given the potential negative impact on the prognosis of patients who delay or interrupt allopathic services. Patients with untreated seizure disorders risk severe brain injury [ 37 ]depression [ 38 ] and increased risk of mortality [ 39 , 40 ], while often being restricted from participating in normal daily activities, including school or employment. Given that capacity to effectively control many seizure disorders exists locally at no cost (specifically treatment for epilepsy), patients seeking traditional treatment for uncontrolled seizure disorders may be delaying effective biomedical treatment.…”

Section: Discussionmentioning

confidence: 99%

Mixed methods inquiry into traditional healers’ treatment of mental, neurological and substance abuse disorders in rural South Africa

et al. 2017

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BackgroundTraditional healers are acceptable and highly accessible health practitioners throughout sub-Saharan Africa. Patients in South Africa often seek concurrent traditional and allopathic treatment leading to medical pluralism.Methods & findingsWe studied the cause of five traditional illnesses known locally as “Mavabyi ya nhloko” (sickness of the head), by conducting 27 in-depth interviews and 133 surveys with a randomly selected sample of traditional healers living and working in rural, northeastern South Africa. These interviews were carried out to identify treatment practices of mental, neurological, and substance abuse (MNS) disorders. Participating healers were primarily female (77%), older in age (median: 58.0 years; interquartile range [IQR]: 50–67), had very little formal education (median: 3.7 years; IQR: 3.2–4.2), and had practiced traditional medicine for many years (median: 17 years; IQR: 9.5–30). Healers reported having the ability to successfully treat: seizure disorders (47%), patients who have lost touch with reality (47%), paralysis on one side of the body (59%), and substance abuse (21%). Female healers reported a lower odds of treating seizure disorders (Odds Ratio (OR):0.47), patients who had lost touch with reality (OR:0.26; p-value<0.05), paralysis of one side of the body (OR:0.36), and substance abuse (OR:0.36) versus males. Each additional year of education received was found to be associated with lower odds, ranging from 0.13–0.27, of treating these symptoms. Each additional patient seen by healers in the past week was associated with roughly 1.10 higher odds of treating seizure disorders, patients who have lost touch with reality, paralysis of one side of the body, and substance abuse. Healers charged a median of 500 South African Rand (~US$35) to treat substance abuse, 1000 Rand (~US$70) for seizure disorders or paralysis of one side of the body, and 1500 Rand (~US$105) for patients who have lost touch with reality.ConclusionsWhile not all healers elect to treat MNS disorders, many continue to do so, delaying allopathic health services to acutely ill patients.

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Section: Discussionmentioning

confidence: 99%

Mixed methods inquiry into traditional healers’ treatment of mental, neurological and substance abuse disorders in rural South Africa

et al. 2017

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“…The prevalence of MDD in patients with epilepsy has been estimated to be 20-22%, when DSM-IV criteria is used [6,33,34]. MDD prevalence in the general population is estimated around 2.4-3.8% [35].…”

Section: Depressionmentioning

confidence: 99%

Depression and quality of life in patients with epilepsy in Northwest Greece

Siarava

Hyphantis

Katsanos

et al. 2019

Seizure

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The purpose of the present study was to compare depression and QoL between patients with epilepsy and healthy controls, evaluating potentially related factors to depression and QoL in patients with epilepsy in Northwest Greece. Methods: A case study was conducted in adult patients with epilepsy followed up at the University Hospital of Ioannina and in healthy controls. The Patient Health Questionnaire (PHQ-9) for depression's severity evaluation, the WHOQOL-BREF questionnaire for the QoL estimation and the Adverse Event Profile (AEP) questionnaire for the Antiepileptic Drugs (AEDs) adverse effects assessment were used. Results: Seventy patients with epilepsy and 70 controls were recruited. The PHQ-9 score was higher in patients compared to controls and slightly higher than reported in patients with epilepsy. PHQ-9 was significantly associated with the AEP score. Our patients had a poorer QoL compared to controls. The level of education, the AEP and the PHQ-9 scores were associated to QoL, the last two being the most powerful predictors of QoL. Conclusion: Patients with epilepsy in Northwest Greece had higher rates of depression than reported in patients with epilepsy and poorer QoL compared to controls. The adverse effects of AEDs were related to depression in our study, while the adverse effects of AEDs and depression were more powerful predictors of QoL compared to demographics and other characteristics of epilepsy.

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“…The most acceptable methods have been patient-reported measures, such as the Morisky Medication Adherence Scales MMAS-4 and MMAS-8 29,31–33. Incomplete adherence to treatment has been associated with several clinical and psychosocial determinants.…”

Section: Introductionmentioning

confidence: 99%

Association between addressing antiseizure drug side effects and patient-reported medication adherence in epilepsy

Moura¹,

Carneiro²,

Cole³

et al. 2016

PPA

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Background and aimAdherence to treatment is a critical component of epilepsy management. This study examines whether addressing antiepileptic drug (AED) side effects at every visit is associated with increased patient-reported medication adherence.Patients and methodsThis study identified 243 adults with epilepsy who were seen at two academic outpatient neurology settings and had at least two visits over a 3-year period. Demographic and clinical characteristics were abstracted. Evidence that AED side effects were addressed was measured through 1) phone interview (patient-reported) and 2) medical records abstraction (physician-documented). Medication adherence was assessed using the validated Morisky Medication Adherence Scale-4. Complete adherence was determined as answering “no” to all questions.ResultsSixty-two (25%) patients completed the interviews. Participants and nonparticipants were comparable with respect to demographic and clinical characteristics; however, a smaller proportion of participants had a history of drug-resistant epilepsy than nonparticipants (17.7% vs 30.9%, P=0.04). Among the participants, evidence that AED side effects were addressed was present in 48 (77%) medical records and reported by 51 (82%) patients. Twenty-eight (45%) patients reported complete medication adherence. The most common reason for incomplete adherence was missed medication due to forgetfulness (n=31, 91%). There was no association between addressing AED side effects (neither physician-documented nor patient-reported) and complete medication adherence (P=0.22 and 0.20).Discussion and conclusionAmong patients with epilepsy, addressing medication side effects at every visit does not appear to increase patient-reported medication adherence.

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Prevalence and correlates of major depressive disorder (MDD) among adolescent patients with epilepsy attending a Nigerian neuropsychiatric hospital

Cited by 11 publications

References 50 publications

Mixed methods inquiry into traditional healers’ treatment of mental, neurological and substance abuse disorders in rural South Africa

Mixed methods inquiry into traditional healers’ treatment of mental, neurological and substance abuse disorders in rural South Africa

Depression and quality of life in patients with epilepsy in Northwest Greece

Association between addressing antiseizure drug side effects and patient-reported medication adherence in epilepsy

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