Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study

Ofori-Atta, Angela; Reynolds, Nancy; Antwi, Sampson; Renner, Lorna; Nichols, Justin; Lartey, Margaret; Amissah, Kofi; Tettey, Jonas Kusah; Alhassan, Amina; Ofori, Irene Pokuaa; Catlin, Ann Christine; Gan, Geliang; Kyriakides, Tassos C.; Paintsil, Elijah

doi:10.1080/09540121.2018.1537463

Cited by 13 publications

(9 citation statements)

References 74 publications

(77 reference statements)

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“…We also observed a lower rate of caregiver depression in our PHIV group than observed in African studies. . No association was found between caregiver depression and developmental outcomes in our study, although such associations have been observed in earlier studies .…”

Section: Discussioncontrasting

confidence: 69%

Low risk of neurodevelopmental impairment among perinatally acquired HIV‐infected preschool children who received early antiretroviral treatment in Thailand

et al. 2019

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Introduction Antiretroviral therapy ( ART ) is recommended in perinatally HIV‐infect ed ( PHIV ) infants immediately upon diagnosis. We aimed to compare neurodevelopmental outcomes between PHIV children who initiated ART within 12 months of life and perinatally HIV‐ exposed uninfected ( PHEU ) children and to assess neurodevelopmental outcomes by timing of ART . Methods This prospective cohort study included Thai children aged 12 to 56 months who were assessed with the Mullen Scales of Early Learning ( MSEL ) at enrolment and at 48 weeks. Global Developmental Impairment ( GDI ) was defined as Early Learning Composite ( ELC ) ≤ 70 on the MSEL ; typical developmental pattern was defined as ELC > 70 at both visits. Logistic regression was used to compare prevalence of any GDI . Predictors of changing ELC scores were analysed with generalized estimating equations linear regression model. Results From 2016 to 2017, 50 PHIV (twenty‐seven early ART within three months and twenty‐three standard ART within three to twelve months) and 100 PHEU children were enrolled. Median ( IQR ) age at first assessment was 28 (19 to 41) months. PHIV children had lower age‐relevant Z scores for weight, height and head circumference compared to the PHEU group ( p < 0.05). The prevalence of overall GDI was 18% (95% CI 11 to 27) and 32% (95% CI 20 to 47) in PHEU and PHIV children respectively ( p = 0.06). In subgroup analysis, 22% (95% CI 9 to 42) of early ART PHIV children and 44% (95% CI 23 to 66) of standard ART PHIV children had overall GDI . There was a higher rate of GDI in standard ART PHIV children ( p = 0.01), but not in the early ART group ( p = 0.62) when compared with PHEU children. The standard ART PHIV group demonstrated lower typical developmental pattern than both the early ART P...

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Section: Discussioncontrasting

confidence: 69%

Low risk of neurodevelopmental impairment among perinatally acquired HIV‐infected preschool children who received early antiretroviral treatment in Thailand

et al. 2019

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“…At each time point, adjusted mean BDI scores were consistently lower for caregivers of children who had completed the disclosure process. Caregivers of children living with HIV have been found to have a high prevalence of depression symptoms, and our findings suggest disclosure may help to alleviate the burden in this high-risk group [37,38]. Interestingly, we also found CDI scores in the current study to be significantly correlated with the BDI scores of caregivers (r = 0.19, p = 0.019).…”

Section: Discussionsupporting

confidence: 68%

Sankofa pediatric HIV disclosure intervention did not worsen depression scores in children living with HIV and their caregivers in Ghana

et al. 2020

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Background The ‘Sankofa’ pediatric HIV disclosure study (2013–2017) was an intervention that aimed to address the low prevalence of disclosure of HIV status in Ghana. Methods We conducted a cross-sectional study at the intervention site in Kumasi, Ghana, in 2019, (2 years after study closure) and administered the 21-item Beck Depression Inventory (BDI) and the 10-item Child Depression Inventory (CDI) to caregiver-child dyads who received the intervention. Results We enrolled 65% (N = 157) of the original dyads in the present study. Between Sankofa enrollment baseline and the present study, both children and caregivers had significant (p < 0.0001) mean reductions in CDI scores and BDI scores, respectively. CDI scores of the children were significantly correlated with BDI scores of the caregivers (r = 0.019, p = 0.019). No statistically significant associations between disclosure status and either CDI score or BDI score were found. Conclusions Our findings did not support caregivers’ fears that disclosure leads to depression. Trial registration ClinicalTrials.gov Identifier: NCT01701635 (date of registration Oct 5, 2012).

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“…At each time point, adjusted mean BDI scores were consistently lower for caregivers of children who had completed the disclosure process. Caregivers of children living with HIV have been found to have a high prevalence of depression symptoms, and our ndings suggest disclosure may help to alleviate the burden in this high-risk group [36,37]. Interestingly, we also found CDI scores in the current study to be signi cantly correlated with the BDI scores of caregivers (r = 0.19, p = 0.019).…”

Section: Discussionsupporting

confidence: 65%

Sankofa Pediatric HIV Disclosure Intervention Did Not Worsen Depression Scores in Children Living with HIV and their Caregivers in Ghana

Radcliffe

Sam

Matos

et al. 2020

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Abstract BackgroundThe ‘Sankofa’ pediatric HIV disclosure study (2013–2017) was an intervention that aimed to address the low prevalence of disclosure of HIV status in Ghana.MethodsWe conducted a cross-sectional study at the intervention site in Kumasi, Ghana, in 2019, (2 years after study closure) and administered the 21-item Beck Depression Inventory (BDI) and the 10-item Child Depression Inventory (CDI) to caregiver-child dyads who received the intervention.ResultsWe enrolled 65% (N = 157) of the original dyads in the present study. Between Sankofa enrollment baseline and the present study, both children and caregivers had significant (p < 0.0001) mean reductions in CDI scores and BDI scores, respectively. CDI scores of the children were significantly correlated with BDI scores of the caregivers (r = 0.019, p = 0.019). No statistically significant associations between disclosure status and either CDI score or BDI score were found.ConclusionsOur findings did not support caregivers’ fears that disclosure leads to depression.Trial Registration: NCT01701635 (ClinicalTrials.gov Identifier)

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Prevalence and correlates of depression among caregivers of children living with HIV in Ghana: findings from the Sankofa pediatric disclosure study

Cited by 13 publications

References 74 publications

Low risk of neurodevelopmental impairment among perinatally acquired HIV‐infected preschool children who received early antiretroviral treatment in Thailand

Low risk of neurodevelopmental impairment among perinatally acquired HIV‐infected preschool children who received early antiretroviral treatment in Thailand

Sankofa pediatric HIV disclosure intervention did not worsen depression scores in children living with HIV and their caregivers in Ghana

Sankofa Pediatric HIV Disclosure Intervention Did Not Worsen Depression Scores in Children Living with HIV and their Caregivers in Ghana

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