Prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda: cross-sectional, population-based study

Mubangizi, Vincent; Maling, Samuel; Obua, Celestino; Tsai, Alexander C.

doi:10.21203/rs.2.15967/v3

Cited by 7 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 4 A recent study on dementia among older-age persons in rural Uganda estimated the prevalence to be 20%. 5 ADRD exerts enormous negative consequences on the lives of caregivers and family friends, especially in LMICs where health systems are not well developed and under-resourced. 6 – 9 Moreover, studies on dementia-related caregiving burden in LMICs report that caring for people with ADRD is correlated with increased caregivers’ stress, depression, and anxiety.…”

mentioning

confidence: 99%

Caring for people with dementia in rural Uganda: qualitative study of caregiving burden experienced by informal and formal caregivers

Ainamani

Alele

Rukundo

et al. 2020

Journal of Global Health Reports

Self Cite

View full text Add to dashboard Cite

Background Background The rising incidence of Alzheimer's disease among older-age adults worldwide has been accompanied by an increase in caregiving burden. Limited work has examined the lived experiences of both formal and informal caregivers of people living with dementia in low-income countries. Methods Methods We conducted one-on-one, in-depth qualitative interviews with a purposive sample of 10 informal caregivers and 5 formal caregivers of people living with dementia in Mbarara, Uganda. They were interviewed about their experiences caring for people with dementia until thematic saturation was reached. All interviews were audio recorded, transcribed into English, and thematically analysed. Results Results Two primary themes emerged from the data: patient factors influencing caregiving burden (problematic behaviours, such as wandering and aggression) and patient physical health and cognitive deterioration (namely, loss of memory and incontinence). Psychosocial and economic aspects of caregiving burden included financial costs, family conflicts, anxiety, stigma, and substance misuse. Conclusions Conclusions Both formal and informal caregivers of people living with dementia experience physical, financial, and psychological stressors. Interventions aimed at reducing these stressors would benefit caregivers as well as improve quality of care for people living with dementia. Ainamani HE, Alele PE, Rukundo GZ, et al. Caring for people with dementia in rural Uganda: qualitative study of caregiving burden experienced by informal and formal caregivers.

show abstract

mentioning

confidence: 99%

Caring for people with dementia in rural Uganda: qualitative study of caregiving burden experienced by informal and formal caregivers

Ainamani

Alele

Rukundo

et al. 2020

Journal of Global Health Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…[30] Another study from rural Uganda reported a dementia prevalence of 20% among the general population of persons older than 60 years. [31] On the other hand, Mukisa and colleagues reported a 20% prevalence of dementia among patients who recently recovered from stroke. [21] Several factors contribute to cognitive deficits in older persons.…”

Section: Discussionmentioning

confidence: 99%

Cognitive functioning and prevalence of seizures among older persons in Uganda: A hospital-based, cross-sectional study

et al. 2022

View full text Add to dashboard Cite

There is limited data on the prevalence of seizures and dementia among older persons in Uganda. We evaluated cognitive functioning, and the prevalence and factors associated with seizures among older persons attending an outpatient medical clinic in Uganda. We randomly selected older adults (60 years and above) attending Kiruddu National Referral Hospital medical outpatient clinics between October 2020 and March 2021. We excluded individuals with a history of head injury, brain tumors, mental retardation, co-morbidity with HIV and patients who have had recent brain surgery. Cognitive functioning was assessed using the Identification for Dementia in Elderly Africans (IDEA) tool. We enrolled 407 participants, with a median (inter-quartile range) age of 67 (64–73) years. Majority were female (n = 292, 71.7%). The prevalence of seizure was 1.5% (95% confidence interval [CI]: 0.7–3.3). All 6 participants reported generalized tonic-clonic seizure type. Self-reported seizure was associated with being female (adjusted prevalence ratio [aPR]: 0.79, 95%CI: 0. 67–0.93, P = .02) and residing in Mukono district (aPR: 17.26, 95%CI: 1.64–181.55, P = .018). Overall, 114 (28.1%) participants had cognitive deficit; 9 (2.2%) dementia and 105 (25.9%) impaired cognition. Cognitive deficit was independently associated with female gender (aPR: 0.61, 95%CI: 0.44–0.85, P = .003), formal employment (aPR: 0.53, 95%CI: 0.35–0.81, P = .003), age 70–74 (aPR: 1.69, 95%CI: 1.00–2.86, P = .049), and ≥ 75 years (aPR: 2.81, 95%CI: 1.71–4.61, P = .001). Prevalence of seizures among participants with cognitive deficit was 5.3% (6/114). Among older persons attending a medical clinic in Uganda, almost one-third had cognitive deficit with seizure prevalence being higher among these individuals.

show abstract

“…4 Office of Research Administration, Mbarara University of Science and Technology, Mbarara, Uganda. 5 Department of Pharmacology and Therapeutics, Mbarara University of Science and Technology, Mbarara, Uganda. 6 Mwanza Intervention Trials Unit, Mwanza, Tanzania.…”

Section: Abbreviationsmentioning

confidence: 99%

“…According to the Uganda Bureau Of Statistics 2016 report, out of the 212,446 elderly of 60 years and above in Southwestern Uganda, 90,039 are men and 122,407 are women [4]. A recent study indicated that 20% of the population of those aged 60 years and over in Southwestern Uganda have dementia implying a relatively high prevalence of dementia [5]. Much of the care for persons with chronic illnesses and disability is provided by their families and other informal structures within the community [6].…”

Section: Introductionmentioning

confidence: 99%

Informal support for people with Alzheimer’s disease and related dementias in rural Uganda: a qualitative study

Nankinga

Maling

Chemali

et al. 2020

Int J Ment Health Syst

Self Cite

View full text Add to dashboard Cite

Background: The generation of people getting older has become a public health concern worldwide. People aged 65 and above are the most at risk for Alzheimer's disease which is associated with physical and behavioral changes. This nurtures informal support needs for people living with dementia where their families together with other community members are the core providers of day to day care for them in the rural setting. Despite global concern around this issue, information is still lacking on informal support delivered to these people with dementia. Objective: Our study aimed at establishing the nature of informal support provided for people with dementia (PWDs) and its perceived usefulness in rural communities in South Western Uganda. Methods: This was a qualitative study that adopted a descriptive design and conducted among 22 caregivers and 8 opinion leaders in rural communities of Kabale, Mbarara and Ibanda districts in South Western Uganda. The study included dementia caregivers who had been in that role for a period of at least 6 months and opinion leaders in the community. We excluded trained health workers. Results: The study highlights important forms of informal support offered to PWDs such as support in activities of daily living, enabling access to medical attention, recovering misplaced items, provision of herbal remedy, informal counseling, and sourcing carers from other families to offer presence and support in the hope to impact positively on behavioral outbursts and the frustration of living with dementia. Conclusion: The study revealed various forms of informal support that are available for PWDs in South Western Uganda and stressed the role of caregivers and the perceived usefulness of the care provided.

show abstract

Prevalence and correlates of Alzheimer’s disease and related dementias in rural Uganda: cross-sectional, population-based study

Cited by 7 publications

References 17 publications

Caring for people with dementia in rural Uganda: qualitative study of caregiving burden experienced by informal and formal caregivers

Caring for people with dementia in rural Uganda: qualitative study of caregiving burden experienced by informal and formal caregivers

Cognitive functioning and prevalence of seizures among older persons in Uganda: A hospital-based, cross-sectional study

Informal support for people with Alzheimer’s disease and related dementias in rural Uganda: a qualitative study

Contact Info

Product

Resources

About