Prevalence and control implications of bovine trypanosomes in endemic areas of northern Uganda

Mandela, Wangoola Robert; Eddie, Wampande; Welburn, Susan C.; Bugeza, James; Bahungirehe, J. B.; Okwasiimire, Rodney; Baliddawa, C. W.; Waiswa, Charles

doi:10.1007/s11250-020-02353-z

Cited by 2 publications

(1 citation statement)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While successful surveillance and control efforts have led to a marked reduction in cases (Franco et al., 2018), these pathogens have historically shown strong capacity for resurgence and control efforts are complicated by the potential for asymptomatic patients to serve as parasite reservoirs (Capewell et al., 2016; Kennedy & Rodgers, 2019; Trindade et al., 2016). Moreover, infection of livestock promulgates economic instability in communities reliant upon agriculture (Mandela et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei

Walsh

Hill

2021

Molecular Microbiology

View full text Add to dashboard Cite

Trypanosoma brucei and other African trypanosomes are vector‐borne parasites that cause substantial human suffering across sub‐Saharan Africa. The T. brucei life cycle is punctuated by numerous developmental stages, each occurring in a specific environmental niche and characterized by a unique morphology, metabolism, surface protein coat, and gene expression profile. The environmental cues and signaling pathways that drive transitions between these stages remain incompletely understood. Recent studies have started to fill this gap in knowledge. Likewise, several new studies have expanded our understanding of parasite movement through specific tissues and the parasite's ability to alter movement in response to external cues. Life cycle stage differentiation and motility are intimately integrated phenomena, as parasites must be at the right place (i.e., within a specific environmental milieu) at the right time (i.e., when they are appropriately staged and preadapted for perceiving and responding to signals) in order to complete their life cycle. In this review, we highlight some of the recent work that has transformed our understanding of signaling events that control parasite differentiation and motility. Increased knowledge of T. brucei environmental sensing and signal transduction advances our understanding of parasite biology and may direct prospective chemotherapeutic and transmission blockade strategies that are critical to eradication efforts.

show abstract

Section: Introductionmentioning

confidence: 99%

Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei

Walsh

Hill

2021

Molecular Microbiology

View full text Add to dashboard Cite

show abstract

Prevalence of African animal trypanosomiasis among livestock and domestic animals in Uganda: a systematic review and meta-regression analysis from 1980 to 2022

Rascón-García,

Martínez-López,

Cecchi

et al. 2023

Sci Rep

View full text Add to dashboard Cite

African animal trypanosomiasis (AAT) is one of the major constraints to animal health and production in sub-Saharan Africa. To inform AAT control in Uganda and help advance along the progressive control pathway (PCP), we characterized AAT prevalence among eight host species in Uganda and explored factors that influence the prevalence variation between studies. We retrieved AAT prevalence publications (n = 2232) for Uganda (1980–2022) from five life sciences databases, focusing on studies specifying AAT detection methods, sample size, and the number of trypanosome-positive animals. Following PRISMA guidelines, we included 56 publications, and evaluated publication bias by the Luis Furuya-Kanamori (LFK) index. National AAT prevalence under DNA diagnostic methods for cattle, sheep and goats was 22.15%, 8.51% and 13.88%, respectively. Under DNA diagnostic methods, T. vivax was the most common Trypanosoma sp. in cattle (6.15%, 95% CI: 2.91–10.45) while T. brucei was most common among small ruminants (goats: 8.78%, 95% CI: 1.90–19.88, and sheep: 8.23%, 95% CI: 4.74–12.50, respectively). Northern and Eastern regions accounted for the highest AAT prevalence. Despite the limitations of this study (i.e., quality of reviewed studies, underrepresentation of districts/regions), we provide insights that could be used for better control of AAT in Uganda and identify knowledge gaps that need to be addressed to support the progressive control of AAT at country level and other regional endemic countries with similar AAT eco-epidemiology.

show abstract

Prevalence and control implications of bovine trypanosomes in endemic areas of northern Uganda

Cited by 2 publications

References 30 publications

Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei

Right place, right time: Environmental sensing and signal transduction directs cellular differentiation and motility in Trypanosoma brucei

Prevalence of African animal trypanosomiasis among livestock and domestic animals in Uganda: a systematic review and meta-regression analysis from 1980 to 2022

Contact Info

Product

Resources

About