Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis

Mudawi, Hatim; Smith, H.M.; Fletcher, I.; Fedail, S S

doi:10.1002/jmv.20865

Cited by 24 publications

(35 citation statements)

References 23 publications

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“…2,9,19,29,30 Among the 13 articles included in the fi nal step of the review, ten were cross-sectional studies, 8,9,19,29,30,36,37,39,40,45 one was a retrospective cases series, 6 one was a prospective cases series 2 and the other was a cases series with an external control group. 32 Five studies 6,32,39,40,45 were conducted in Brazil, fi ve in Egypt, 2,9,19,29,30 two in Sudan, 36,37 one in Ethiopia 8 and one in Kenya. 9 A higher prevalence of HCV infection was found in the SM population of Egypt, compared to the other countries (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies 2,6,19,32,36,37,40,45 sought to determine the serologic prevalence of HCV infection in an SM population and one study proposed to verify any epidemiologic relationship of schistosomiasis and HBV and HCV serologic markers. 30 Six studies 6,9,29,37,39,40 aimed to evaluate the severity of hepatic lesions and morbidity of hepatitis C when associated with SM and to correlate this with serologic markers.…”

Section: Resultsmentioning

confidence: 99%

“…30 Six studies 6,9,29,37,39,40 aimed to evaluate the severity of hepatic lesions and morbidity of hepatitis C when associated with SM and to correlate this with serologic markers. The mean age of humans enrolled in these studies was 33.7 years and in four articles subjects were > 40 years 6,29,32,36 (Table 2). …”

Section: Resultsmentioning

confidence: 99%

“…Six studies did not mention the exclusion criteria adopted. 2,9,19,30,32,36 The most commonly chosen technique of HCV diagnosis was 3 rd generation anti-HCV ELISA, utilized in fi ve studies. 8,9,36,37,45 Four other studies utilized 2 nd generation anti-HCV ELISA.…”

Section: Resultsmentioning

confidence: 99%

“…2,9,19,30,32,36 The most commonly chosen technique of HCV diagnosis was 3 rd generation anti-HCV ELISA, utilized in fi ve studies. 8,9,36,37,45 Four other studies utilized 2 nd generation anti-HCV ELISA. 2,19,29,30 The quantifi cation of the viral titers was performed by HCV RNA PCR in seven studies.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Association between Schistosomiasis mansoni and hepatitis C: systematic review

et al. 2013

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OBJECTIVE:To perform a systematic review of the prevalence of the HCV/S. mansoni co-infection and associated factors in Schistosoma mansoni-infected populations. METHODS:The bibliographic search was carried out using the Medline, Lilacs, SciELO, Cochrane Library and Ibecs databases. The criteria for the studies' selection and the extraction data were based on systematic review methods. Forty fi ve studies were found, with nine being excluded in a fi rst screening. Thirteen articles were used for data extraction. RESULTS:The HCV infection rates in schistosomiasis populations range from 1% in Ethiopia to 50% in Egypt. Several studies had poorly defi ned methodologies, even in areas characterized by an association between hepatitis C and schistosomiasis, such as Brazil and Egypt, which meant conclusions were inconsistent. HCV infection rates in schistosomotic populations were heterogeneous and risk factors for acquiring the virus varied widely. CONCLUSIONS:Despite the limitations, this review may help to identify regions with higher rates of hepatitis C and schistosomiasis association. However, more studies are necessary for the development of public health policies on prevention and control of both diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Association between Schistosomiasis mansoni and hepatitis C: systematic review

et al. 2013

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Genotypes and viral load of hepatitis C virus among persons attending a voluntary counseling and testing center in Ethiopia

Abreha

Woldeamanuel

Pietsch

et al. 2011

Journal of Medical Virology

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The prevalence of different genotypes of hepatitis C virus (HCV) in Ethiopia is not known. HCV genotypes influence the response to therapy with alpha-interferon alone or in combination with ribavirin. A cross sectional study was conducted on attendees of voluntary counseling and testing center. Serum samples from 1,954 (734 HIV positive and 1,220 HIV negative) individuals were screened for HCV antibody. Active HCV infection was confirmed by quantitative PCR in 18 of the 71 samples with anti-HCV antibodies. The HCV viral load ranged from 39,650 to 9,878,341 IU/ml (median 1,589,631 IU/ml) with no significant difference [χ(2)(17) = 18.00, P = 0.389] between persons positive or negative for HIV. The viral load of HCV was, however, higher in older study subjects (r = 0.80, P = 0.000). HCV genotypes were determined using the VERSANT HCV Genotype Assay (LiPA) and sequence analysis of the NS5b region of the HCV genome. Diverse HCV genotypes were found including genotypes 1, 2, 4, and 5. There was no difference in the distribution regarding the HIV status. As in other parts of the world, genotyping of HCV must be considered whenever HCV is incriminated as a cause of hepatitis.

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Molecular and Contextual Markers of Hepatitis C Virus and Drug Abuse

et al. 2009

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The spread of hepatitis C virus (HCV) infection involves a complex interplay of social risks, and molecular factors of both virus and host. Injection drug abuse is the most powerful risk factor for HCV infection, followed by sexual transmission and additional non-injection drug abuse factors such as co-infection with other viruses and barriers to treatment. It is clearly important to understand the wider context in which the factors related to HCV infection occur. This understanding is required for a comprehensive approach leading to the successful prevention, diagnosis, and treatment of HCV. An additional consideration is that current treatments and advanced molecular methods are generally unavailable to socially disadvantaged patients. Thus, the recognition of behavioral/social, viral, and host factors as components of an integrated approach to HCV is important to help this vulnerable group. Equally important, this approach is key to the development of personalized patient treatment – a significant goal in global healthcare. In this review, we discuss recent findings concerning the impact of drug abuse, epidemiology, social behavior, virology, immunopathology, and genetics on HCV infection and the course of disease.

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Prevalence and common genotypes of HCV infection in Sudanese patients with hepatosplenic schistosomiasis

Cited by 24 publications

References 23 publications

Association between Schistosomiasis mansoni and hepatitis C: systematic review

Association between Schistosomiasis mansoni and hepatitis C: systematic review

Genotypes and viral load of hepatitis C virus among persons attending a voluntary counseling and testing center in Ethiopia

Molecular and Contextual Markers of Hepatitis C Virus and Drug Abuse

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