Prevalence and clinical significance of left atrial thrombus in nonrheumatic atrial fibrillation

Tsai, Liang Miin; Lin, Li Jen; Teng, Jeng Kai; Chen, Jyh Hong

doi:10.1016/s0167-5273(96)02862-8

Cited by 50 publications

(33 citation statements)

References 29 publications

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“…30,31) The frequency of left atrial thrombus was 15% in our patients with nonvalvular AF. Our finding was similar to the results of Manning, et al 9) who found left atrial thrombus in 34 of 230 (15%) patients with AF; however, 8% of their patients had rheumatic mitral valve disease.…”

Section: Discussionmentioning

confidence: 67%

Right Atrial Appendage Function in Patients with Chronic Nonvalvular Atrial Fibrillation.

Bilge¹,

Eryonucu²,

Güler³

et al. 2000

Jpn Heart J

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SUMMARYTo assess right atrial appendage (RAA) flow and its possible relationship to left atrial appendage (LAA) flow in chronic nonvalvular atrial fibrillation (AF), transesophageal echocardiography (TEE) was performed in 26 patients with chronic nonvalvular AF (group I). For the purpose of comparison, an additional group of 27 patients with chronic valvular AF due to mitral stenosis (group II) was analyzed. The clinically estimated duration of AF in group I was significantly longer than that of group II (8.7 ± 3.4 versus 2.7 ± 1.1 years). Although right atrial size and RAA maximal area were larger in group I than those in group II, left atrial size was larger in group II than that in group I. Group II had larger LAA maximal areas than group I, but this difference did not reach statistical significance. The two groups were not different with respect to the RAA or LAA emptying velocities. Significant correlations were observed between echocardiographic parameters of the two atria in patients with nonvalvular AF (r range, 0.4 to 0.7). In contrast, in patients with valvular AF, no correlation was observed between the echocardiographic parameters of the two atria (appendage emptying velocity, r = 0.38, p = 0.051; atrial size, r = − 0.03, p = 0.89; maximal appendage area, r = 0.07, p = 0.75, respectively). There were no significant differences in the presence of right and left atrial spontaneous echo contrast and thrombus between the groups. All of the right and left atrial thrombi were confined to their respective appendages and were found in the atria with spentaneous echo contrast. Both RAA and LAA thrombi were present in one patient. In conclusion, our findings suggest that AF could affect both atria equally in nonvalvular AF, in contrast to valvular AF. Therefore, the assessment of RAA function as well as LAA may be important in patients with chronic nonvalvular AF. (Jpn Heart J 2000; 41: 451-462)

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Section: Discussionmentioning

confidence: 67%

Right Atrial Appendage Function in Patients with Chronic Nonvalvular Atrial Fibrillation.

Bilge¹,

Eryonucu²,

Güler³

et al. 2000

Jpn Heart J

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show abstract

“…In AF patients, many factors such as prior stroke, age, hypertension, diabetes, female sex, peripheral artery disease and structural heart disease play part in the increase of stroke risk. It has been shown in AF patients that LV systolic dysfunction, is associated with both LA thrombus and non-cardioembolic stroke (13). LV function is an important determinant of LAA velocities.…”

Section: Discussionmentioning

confidence: 99%

Effect of left ventricular diastolic dysfunction on left atrial appendage function and thrombotic potential in nonvalvular atrial fibrillation

Demirçelik¹,

Çetın²,

Çiçekçioğlu³

et al. 2014

Anadolu Kardiyol Derg

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Objective: We aimed to investigate effects of left ventricular diastolic dysfunction on left atrial appendage functions, spontaneous echo contrast and thrombus formation in patients with nonvalvular atrial fibrillation. Methods: In 58 patients with chronic nonvalvular atrial fibrilation and preserved left ventricular systolic function, left atrial appendage functions, left atrial spontaneous echo contrast grading and left ventricular diastolic functions were evaluated using transthoracic and transoesophageal echocardiogram. Patients divided in two groups: Group D (n=30): Patients with diastolic dysfunction, Group N (n=28): Patients without diastolic dysfunction. Categorical variables in two groups were evaluated with Pearson's chi-square or Fisher's exact test. The significance of the lineer correlation between the degree of spontaneous echo contrast (SEC) and clinical measurements was evaluated with Spearman's correlation analysis. Results: Peak pulmonary vein D velocity of the Group D was significantly higher than the Group N (p=0.006). However, left atrial appendage emptying velocity, left atrial appendage lateral wall velocity, peak pulmonary vein S, pulmonary vein S/D ratio were found to be significantly lower in Group D (p=0.028, p<0.001, p<0.001; p<0.001). Statistically significant negative correlation was found between SEC in left atrium and left atrial appendage emptying, filling, pulmonary vein S/D levels and lateral wall velocities respectively (r=-0.438, r=-0.328, r=-0.233, r=-0.447). Left atrial appendage emptying, filling, pulmonary vein S/D levels and lateral wall velocities were significantly lower in SEC 2-3-4 than SEC 1 (p=0.003, p=0.029, p<0.001, p=0.002). Conclusion: In patients with nonvalvular atrial fibrillation and preserved left ventricular ejection fraction, left atrial appendage functions are decreased in patients with left ventricular diastolic dysfunction. Left ventricular diastolic dysfunction may constitute a potential risk for formation of thrombus and stroke. (Anadolu Kardiyol Derg 2014; 14: 256-60

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“…61 References excluded at the full paper screening stage (n = 15), with reason for exclusion, are presented in Appendix 9. There were 16 prevalence studies 28,[111][112][113][114][115][116][117][118][119][120][121][122][123][124][125] accepted into the review. Some of the studies investigated the prevalence of more than one pathology.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

“…Of the 16 studies that provided data for the review of the prevalence of clinically significant pathologies in patients with AF, seven studies 28,112,114,115,119,121,124 were retrospective in design, eight 113,[116][117][118]120,122,123,125 were prospective studies, and one 111 was a case-control study.…”

Section: Quantity and Quality Of Research Availablementioning

confidence: 99%

Echocardiography in newly diagnosed atrial fibrillation patients: a systematic review and economic evaluation

Simpson

Stevenson²,

Scope³

et al. 2013

Health Technol Assess

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Prevalence and clinical significance of left atrial thrombus in nonrheumatic atrial fibrillation

Cited by 50 publications

References 29 publications

Right Atrial Appendage Function in Patients with Chronic Nonvalvular Atrial Fibrillation.

Right Atrial Appendage Function in Patients with Chronic Nonvalvular Atrial Fibrillation.

Effect of left ventricular diastolic dysfunction on left atrial appendage function and thrombotic potential in nonvalvular atrial fibrillation

Echocardiography in newly diagnosed atrial fibrillation patients: a systematic review and economic evaluation

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