Prevalence and clinical significance of antiphospholipid antibodies (APA) in viral chronic liver disease

Viral hepatitis and anti-phospholipid antibodies positivity: A systematic review and meta-analysis

“…Similarly, most results were confirmed when we performed separate analyses for case-control [17][18][19]21,[27][28][29][30][31][32][35][36][37][38][39] and cohort studies [15,16,20,33,34] (Supplementary Table S4). …”

“…Three studies [15,33,37] on 395 cases and 232 healthy controls did not show any association between HCV infection and LA positivity (OR 2.25, 95% CI: 0.26-19.51; P = 0.46, I 2 = 0%; P = 0.54, Fig. 3).…”

“…Twenty studies (28 data-sets) [15][16][17][18][19][20][21][27][28][29][30][31][32][33][34][35][36][37][38][39], for a total of 2319 cases and 1901 controls, evaluated aCL positivity in hepatitis patients and healthy controls. Hepatitis was found to be significantly associated with aCL positivity as compared to controls (OR: 11.38, 95% CI: 7.92-16.35; P < 0.00001, Fig.…”

“…Thirteen studies [15,18,20,21,[28][29][30][31][32][33][34]36,37] (19 data-sets on 1724 hepatitis patients and 1349 controls) reported a significant association between hepatitis and anti-␤ 2 GPI positivity (OR: 7.47, 95% CI: 2.83-19.69; P < 0.0001, Fig. 2).…”

“…The analyses were repeated by including only studies classified as "high quality" (NOS ≥6 for case-control and ≥4 for cohort studies) [ studies [32,35,[37][38][39] data of interest were extracted by the abstract, thus no quality assessment could be performed. Of interest, after excluding studies classified as "low quality" [15,17,29,30] and those with only abstract available [32,35,[37][38][39], all results were confirmed (Supplementary Table S2).…”