Prevalence and Clinical Relevance of Autoimmune Neutropenia in Patients with Primary Sjögren's Syndrome

Brito-Zerón, Pilar; Soria, Natalia; Muñoz, Sandra; Bové, Albert; Akasbi, M.; Belenguer, Rafael; Sisó, Antoni; Ramos-Casals, Manuel

doi:10.1016/j.semarthrit.2008.01.014

Cited by 38 publications

(28 citation statements)

References 32 publications

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“…Indeed, in a systematic meta-analysis review, Brito-Zeron et al reported that among the variables present at the time of the initial diagnosis of pSS, lymphopenia (1000/mm 3 ) was the main risk factor for mortality related to infection, with a relative risk of 4.08 (95% confidence interval (CI) 1.67-9.94) [2]. In a prospective cohort study, the risk of hospitalization for infection was higher in patients with neutropenia than in those with normal polynuclear neutrophil counts (24% vs. 9%, p = 0.002) [6].…”

Section: Introductionmentioning

confidence: 97%

“…This susceptibility to infections in autoimmune diseases, including pSS, is due to intrinsic causes related to the disease and also to immunosuppressive treatments. This inherent risk of infections in autoimmune disease could be related to an intrinsic immune deficiency, which could be explained by the immunosenescence or premature aging of the immune system [5] and leukopenia, both of which are common in pSS [2,6]. Indeed, in a systematic meta-analysis review, Brito-Zeron et al reported that among the variables present at the time of the initial diagnosis of pSS, lymphopenia (1000/mm 3 ) was the main risk factor for mortality related to infection, with a relative risk of 4.08 (95% confidence interval (CI) 1.67-9.94) [2].…”

Section: Introductionmentioning

confidence: 99%

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Low Influenza, Pneumococcal and Diphtheria–Tetanus–Poliomyelitis Vaccine Coverage in Patients with Primary Sjögren’s Syndrome: A Cross-Sectional Study

Morel

Letaief

Galéra³

et al. 2019

Vaccines

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Objective: To evaluate vaccination coverage and reasons for non-vaccination in patients with primary Sjögren's syndrome (pSS). Method: A total of 111 patients fulfilling American-European Consensus Group criteria for pSS were interviewed by use of a standardized questionnaire between January 2016 and November 2017 in two French tertiary referral centers for auto-immune diseases. Results: Updated immunization coverage for influenza was 31.5% (n = 35), pneumococcus was 11.7% (n = 13), and diphtheria-tetanus-poliomyelitis (DTP) was 24.3% (n = 27). The main reasons for non-vaccination were fear of side effects from the influenza vaccine (40.3%) and a lack of proposal for the pneumococcal vaccine (72.3%). In vaccinated patients, vaccination was mainly proposed by general practitioners for the influenza vaccine (42.6%) and rheumatologists for the pneumococcal vaccine (41.2%). Probability of influenza vaccination was associated with age (odds ratio/year (OR) 1.04, 95% confidence interval (CI) 1.0-1.1; p = 0.016), history of severe infection (OR 15.9, 95% CI 1.35-186; p = 0.028), low EULAR Sjögren's syndrome disease activity index (OR 0.85, 95% CI 0.75-0.96; p = 0.013), and comorbidities (OR 3.52, 95% CI 1.22-10.2; p = 0.02). Probability of vaccination against pneumococcus was associated with lung comorbidities (OR 3.83, 95% CI 1.11-13.12; p = 0.033) and up-to-date influenza vaccination (OR 3.71, 95% CI 1.08-12.8; p = 0.038). Conclusion: Influenza, pneumococcal, and DTP vaccine coverage was low in patients with pSS included in this study. These results underline the relevance of systematically screening vaccine status in pSS patients and educating patients and physicians on the need for vaccination to improve vaccine coverage in this population.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Low Influenza, Pneumococcal and Diphtheria–Tetanus–Poliomyelitis Vaccine Coverage in Patients with Primary Sjögren’s Syndrome: A Cross-Sectional Study

Morel

Letaief

Galéra³

et al. 2019

Vaccines

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“…Antineutrophil antibodies were shown to be directly involved in the peripheral destruction of neutrophils in SLE patients [7,23,24]. In patients with Sjögren's syndrome, frequency of anti-SSA/Ro and anti-SSB/La positivity were shown to be higher in patients with neutropenia than those without [25]. Our findings that SLE patients with neutropenia were more likely to be seropositive with ANA or anti-dsDNA at the time of the diagnosis, increased tendency for developing neutropenia in patients with anti-SSA/Ro positivity, and hypocomplementemia accompanying admissions with neutropenia support the role of circulating autoantibodies in development of neutropenia.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

2017

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“…pSS is an autoimmune disease characterized by lymphocytic infiltration of the salivary glands and lacrimal glands. It is one of the most common autoimmune disorders associated with B lymphocyte hyper‐reactivity, affecting 3% to 4% of the adult population . Sicca symptoms are the main symptoms.…”

Section: Discussionmentioning

confidence: 99%

Agranulocytosis and mixed‐type autoimmune hemolytic anemia in primary sjögren's syndrome: a case report and review of the literature

et al. 2015

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Primary Sjögren's syndrome (pSS) is a systemic autoimmune disease that presents with sicca symptoms of the main mucosal surfaces. Patients with pSS have a broad spectrum of laboratory features, such as cytopenias and hypergammaglobulinemia. Although hematological abnormalities are usually seen in pSS patients, agranulocytosis and autoimmune hemolytic anemia (AIHA) are rare. Here we describe a 40-year-old woman with pSS who developed both agranulocytosis and mixed-type AIHA. An increased risk of malignancies has also been reported in pSS patients with hematological changes. Although there is no evidence of malignancies, this patient should be closely followed up in case of developing lymphoma.

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Prevalence and Clinical Relevance of Autoimmune Neutropenia in Patients with Primary Sjögren's Syndrome

Cited by 38 publications

References 32 publications

Low Influenza, Pneumococcal and Diphtheria–Tetanus–Poliomyelitis Vaccine Coverage in Patients with Primary Sjögren’s Syndrome: A Cross-Sectional Study

Low Influenza, Pneumococcal and Diphtheria–Tetanus–Poliomyelitis Vaccine Coverage in Patients with Primary Sjögren’s Syndrome: A Cross-Sectional Study

Prevalence and Risk Factors Associated with Neutropenia in Hospitalized Patients with Systemic Lupus Erythematosus

Agranulocytosis and mixed‐type autoimmune hemolytic anemia in primary sjögren's syndrome: a case report and review of the literature

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