Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma

Tajiri, Tomoko; Niimi, Akio; Matsumoto, Hisako; Ito, Isao; Oguma, Tsuyoshi; Otsuka, Kojiro; Takeda, Takumi; Nakaji, Hitoshi; Inoue, Hideki; Iwata, Toshiyuki; Nagasaki, Tadao; Mishima, Michiaki

doi:10.1159/000355706

Cited by 42 publications

(39 citation statements)

References 51 publications

(61 reference statements)

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“…Allergic rhinitis is a predictor of greater severity of asthma when asthmatics were not stratified by age at onset [26,27]. However, 2 longitudinal studies showed that childhood allergic rhinitis is associated with asthma persistence [28] and atopic asthma, but not nonatopic asthma in adulthood [29].…”

Section: Discussionmentioning

confidence: 99%

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Chen

Lee

et al. 2015

Respiration

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Background: Late-onset asthma has been shown to be more severe than early-onset asthma in clinic-based studies. However, population-based studies are scarce, and the predictors of severity have been less studied. Objectives: To determine asthma severity and severity predictors regarding age at onset. Methods: A cross-sectional questionnaire survey was conducted among parents of children from 94 schools in Taiwan in 2004. Asthma severity was defined as short-acting β₂-agonist (SABA), inhaled corticosteroid (ICS) and health care use in the last year. Information on age at onset, demographics, heredity and home exposure was collected. Ordered logistic or logistic regression was used for determining the associations between risk factors and severity. Results: Participants aged 26-50 years were included, resulting in 21,057 (67.8%) participants. Among them, 449 reported ever having had physician-diagnosed asthma, and 381 of those subjects answered the question on age at asthma onset. The risks of rescue SABA, ICS and health care use were generally higher among late-onset (13-50 years) than early-onset (0-12 years) asthmatics. Use of SABA and health care increased from childhood-onset, adolescent- or young adult-onset to adult-onset asthma. Allergic rhinitis was positively associated with SABA use (OR, 9.08; 95% CI, 1.06-77.99) and ICS use (OR, 5.08; 95% CI, 1.47-17.52) in early-onset asthma. Dehumidifier use was negatively associated with SABA use (OR, 0.50; 95% CI, 0.29-0.87) and ICS use (OR, 0.38; 95% CI, 0.19-0.78) in late-onset asthma. Conclusions: In adults, late-onset asthma was more severe than early-onset asthma. Severity, as indicated by SABA and ICS use, was positively associated with allergic rhinitis in early-onset asthma and negatively associated with dehumidifier use in late-onset asthma.

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Section: Discussionmentioning

confidence: 99%

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Chen

Lee

et al. 2015

Respiration

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“…17,18 Furthermore, a previous study found that perennial allergic rhinitis was associated with high FeNO levels and more severe asthma. 21 These observations indicate that high FeNO levels are related more severe eosinophil infiltration in the airway. However, in normal adults, agerelated variations in FeNO data are inconsistent.…”

Section: Discussionmentioning

confidence: 87%

“…FeNO levels also correlated with a higher percentage of eosinophils in the sputum of patients with CVA. 21 These observations indicate that high FeNO levels are related more severe eosinophil infiltration in the airway. In our study, using FEF25-75 as the indicator, the subjects with CVA and high FeNO levels exhibited relatively lower small airway function compared with subjects with normal FeNO levels.…”

Section: Discussionmentioning

confidence: 87%

Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide

Tang

Zhou

Miao

et al. 2016

Clinical Respiratory J

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“…These symptoms of AR was downgraded by many patients as only third of them considered active management of AR as approximation of 70% of responded they do not use any medication regarding the treatment of allergic rhinitis. The literature suggested a strong link between allergic rhinitis and asthma [10]. Based on number of studies, allergic rhinitis is considered as a risk factor for asthma [10].…”

Section: Discussionmentioning

confidence: 99%

“…The literature suggested a strong link between allergic rhinitis and asthma [10]. Based on number of studies, allergic rhinitis is considered as a risk factor for asthma [10]. Both lack of awareness, education and the low severity of symptoms play a significant role in lack of seeking for treatment of allergic rhinitis.…”

Section: Discussionmentioning

confidence: 99%

Cross Sectional Study: Prevalence of Allergic Rhinitis among Adult Asthmatic Patients in Kuwait.

Alkhaldy¹,

Abdelhamy²,

Alsaeedi³

2018

Arch Gen Intern Med

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Background: Allergic rhinitis is prevalent co-morbidity among asthmatic patients. The literature has suggested that it is responsible for poor asthma control. Also, it was found to be an important risk factor for developing of asthma in general population. In Kuwait there are no previous studies that estimated the prevalence of such an association. This study conducted to evaluate the prevalence of allergic rhinitis on adult bronchial asthma in a single center in Kuwait and to examine other common associations.Material and methods: This is a cross sectional study in a single center to evaluate the prevalence and allergic rhinitis and its effect on asthma management among adults. The data was collected through a distribution of an online questionnaire the score for allergic rhinitis (SFAR) to known asthmatic patients who were diagnosed previously with bronchial asthma in a period of six weeks between January and February 2018. Analyzed, discussed and compared to other relevant study.Results: 494 asthmatic patients participated in the questionnaire in a period of 6 weeks. 74.7% were females and 25.3% was males. 39.7% of patients were obese and 13% were smokers. The vast majority of asthmatic patients experienced symptoms of allergic rhinitis in the past 12 months. The most common symptoms experienced were; sneezing (48%), nose itching (45.5%), and cough (35.6%), moreover, 34.4% had runny nose. and 20.9% have had their eyes itching. Interestingly sneezing showed a decreasing prevalence as getting older among males but not females, also runny nose showed biphasic course among age groups. Two thirds (69.4%) of the patients were not using any rhinitis medications.Conclusion: Allergic rhinitis is a common co-morbidity among asthmatic adult patients in our study in Kuwait. The vast majority of patients were not using their rhinitis treatment. Better patient education and adherence to treatment is warranted. Further studies needed to assess the impact of rhinitis treatment on asthma control in Kuwait. AbstractCross sectional study: Prevalence of allergic rhinitis among adult asthmatic patients in Kuwait.

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Prevalence and Clinical Relevance of Allergic Rhinitis in Patients with Classic Asthma and Cough Variant Asthma

Cited by 42 publications

References 51 publications

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Different Severity and Severity Predictors in Early-Onset and Late-Onset Asthma: A Taiwanese Population-Based Study

Clinical features in patients of cough variant asthma with normal and high level of exhaled fractional nitric oxide

Cross Sectional Study: Prevalence of Allergic Rhinitis among Adult Asthmatic Patients in Kuwait.

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