Prevalence and Clinical Outcome of Hepatitis C Infection in Children Who Underwent Cardiac Surgery Before the Implementation of Blood-Donor Screening

Seroprevalence of hepatitis B and hepatitis C markers in adolescents in Southern Brazil

“…This prevalence is lower than that of studies with populations of a similar age in Germany (0.7% and 0.8%) 34,35 , and in the United States (0.3%) 36 . It is also lower that that found in Northern Brazil in volunteers aged below 19 years old (2.1%) 14 and in Pakistan in volunteers aged between 6 and 15 (9.6%) 37 , and corroborates that found in Spain (0%) in a population aged below 19 38 .…”

Hemophilic Siblings With Chronic Hepatitis C: Familial Aggregation of Spontaneous and Treatment-Related Viral Clearance

“…These rates of viral clearance are consistent with other reports in nonhemophilic populations (1), although somewhat less than reported in children and young women infected through contaminated blood products (4,43). In the hemophilia cohort, repeatedly exposed to unsterilized blood products, it is possible that single episodes of spontaneous viral clearance were overshadowed by reinfection during subsequent exposures, as has been demonstrated in thalassemic patients who developed repeated episodes of acute hepatitis C following multiple exposures (44).…”

Natural history of hepatitis C: Its impact on clinical management

“…Children acquiring HCV infection through blood transfusion appear to develop only mild liver disease compared with adults and appear more likely to clear HCV infection spontaneously over time. 11 A possible role for obesity and fatty metamorphosis as a factor accelerating fibrosis has recently been suggested. Yano et al 12 found that the rate of progression to cirrhosis in chronic hepatitis C was accelerated in patients whose initial biopsies showed high grades of necroinflammatory activity and the presence of hepatic fibrosis early on.…”