Prevalence and Clinical Manifestations of Malaria in Aligarh, India

Asma, Umme; Taufiq, Farha; Khan, Wajihullah

doi:10.3347/kjp.2014.52.6.621

Cited by 21 publications

(14 citation statements)

References 22 publications

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“…30,31 In malaria patients, TC, HDL-C, and LDL-C levels were lower compared with patients with other febrile diseases. In particular, HDL-C levels were extremely low in malaria patients.…”

Section: Discussionmentioning

confidence: 97%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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Abstract. The serum lipid profile in malaria patients has been found to differ from that of healthy controls. We investigated serum lipid profile changes in malaria patients over time compared with patients with other febrile diseases. In total, 217 patients were included in the study (111 malaria patients and 106 symptomatic controls, defined as malaria-negative febrile patients). Serum lipid levels (mmol/L) were significantly lower in malaria patients compared with those with other febrile diseases (total cholesterol . No significant differences were found for apolipoprotein A1, apolipoprotein B, and lipoprotein(a). Cholesterol levels increased toward reference values on day 28 ( TC = 3.26-3.98, P < 0.001; HDL-C = 0.43-0.96, P < 0.001; LDL-C = 2.05-2.60, P < 0.001). TG levels decreased from 1.81 on admission to 1.76 (day 3) and 0.88 (day 28; P = 0.130). Lipid profile changes were not correlated with parasitemia or Plasmodium falciparum histidine-rich protein 2 levels. This study confirms characteristic temporary lipid profile changes in malaria. Lipid profile changes demonstrated a good accuracy to discriminate between malaria and other febrile diseases (area under the curve = 0.80 (95% confidence interval = 0.742-0.863, P < 0.001). Several plausible hypotheses exist regarding the pathophysiology of lipid profile changes in malaria. Further studies to elucidate the precise pathways may lead to improved understanding of the underlying pathophysiology.[

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“…30,31 In malaria patients, TC, HDL-C, and LDL-C levels were lower compared with patients with other febrile diseases. In particular, HDL-C levels were extremely low in malaria patients.…”

Section: Discussionmentioning

confidence: 97%

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Visser

Vries

Vingerling

et al. 2017

The American Society of Tropical Medicine and Hygiene

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“…This was somewhat in accordance with the study conducted in central India. 12,16,17 The above result thus indicates that P. vivax is the most widespread infection in India. Electrolyte imbalance, which is considered as consequence of malaria with unknown pathophysiology, indicates severity of infection.…”

Section: Discussionmentioning

confidence: 70%

A Study of Sodium and Potassium on Disturbances in Malaria at Mangalore, Karnataka, India

Naik¹,

Maben²

2019

IJCMSR

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Introduction: Malaria is among the most widespread infectious diseases known to humans. Electrolyte imbalance is one of the major consequences of malaria with studies reporting change in the serum sodium and potassium concentration. Since electrolyte imbalance is relatively unexplored complication. The present study was conducted to determine distribution of sodium and potassium level in patients with different type of malaria and to determine the most common serum abnormality. Material and methods: This was an observation cross sectional. The diagnosis of malaria was made with examination of the peripheral smears and malarial antigen detection rapid card test. 114 diagnosed cases of malaria were enrolled in the study. Evaluation of serum electrolyte (Sodium, Potassium) was done. The data was collected in pre-prepared proforma and then transferred to a master chart for analysis. ANOVA test or Kruskal-Wallis non parametric ANOVA test was used. Level of significance was considered as P≤0.05. Software used for analysis was Graph Pad Prism. Results: Plasmodium Vivax was the most common type of malarial infection. The average serum sodium and potassium among study participants was 132.41 ± 3.11 mEq/L and 3.67 ± 0.40mEq/L respectively. Average serum sodium level was less in the patients affected with Plasmodium falciparum infection. Mild hypokalemia was seen in 50 (43.85%) patients whereas moderate was seen in 1.75% patients. Conclusion: Hyponatremia was the most common electrolyte abnormality followed by hypokalemia seen in malaria infection. Electrolyte abnormalities is a common feature in malarial infection and should be monitored regularly.

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“…Sıtma olgularında sarılık varlığının daha yüksek komplikasyon oranlarını ve daha şiddetli enfeksiyon gelişimini işaret ettiği düşünülmektedir (24). P. falciparum'un etken olduğu sıtma olgularındaki insidansı farklı bölgelerde %2,5 ile %15 aralığında değişmektedir (25,26). Bizim çalışmamızda da diğer bilimsel çalışmaların verilerini destekler şekilde tüm olguların %9,4'ünde sarılık görülmüştür.…”

Section: Discussionunclassified

Retrospective Analysis of Cases with Imported Malaria in Hatay Province of Turkey: Seventy-Five Cases in Ten Years

Şahin

Çabalak

Bal

et al. 2019

Turkiye Parazitol Derg

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Objective: Cases with imported malaria have increased complication and mortality rates because of delayed diagnosis and treatment in non-endemic countries. This study aimed to investigate the incidence and clinical features of imported malaria in our clinic during the past 10 years. Methods:This retrospective study included 75 cases diagnosed as having imported malaria in our clinic between January 2008 and December 2017. The epidemiological data, laboratory findings, treatment data and clinical course of the cases were obtained from system records. Results:Patients were predominantly male (%98.6) with a median age of 51 (23-64) years. All cases were infected with Plasmodium falciparum, had a recent travel history to Sub-Saharan African countries and none had received chemoprophylaxis before travel. The incidence of imported malaria showed a declining trend after 2015. The most common findings were fever (100%), thrombocytopenia (84%) and anemia (72%). Although 8% of patients had presented with severe malaria, none of them died. Conclusion:Despite increasing incidence of imported malaria in our country in recent years, there is a decrease in this number in our region. Since Turkey is one of the countries with the highest prevalence of imported malaria in the world, patients with fever and thrombocytopenia should be questioned whether or not they had a history of travel to malaria-endemic area. ABSTRACT Amaç: Endemik olmayan ülkelerde görülen importe sıtma olguları gecikmiş tanı ve tedaviye sekonder artmış komplikasyon oranı ve mortalite riski taşımaktadır. Bu çalışma ile kliniğimizde son 10 yılda takip edilen importe sıtma olgularının insidansının ve klinik özelliklerinin irdelenmesi amaçlanmıştır. Yöntemler: Bu retrospektif çalışmaya Ocak 2008 -Aralık 2017 tarihleri arasında kliniğimizde importe sıtma tanısı ile takip edilmiş 75 olgu dahil edilmiştir. Olgulara ait epidemiyolojik, laboratuvar, tedavi ve klinik seyre ilişkin verilere sistem kayıtlarından ulaşılmıştır. Bulgular: Olguların 74'ü erkek, 1'i kadın olup ortanca yaş 51(23-64) olarak saptanmıştır. Olguların tamamı Sahra altı Afrika ülkelerine seyahat etmiş ve hiçbiri seyahat öncesinde kemoprofilaksi almamıştır. Tüm olgularda etkenin Plasmodium falciparum olduğu görülmüştür. İmporte sıtma olgu sayısı 2015 sonrasında düşme eğilimindeydi. En sık görülen bulgular sırasıyla ateş (%100), trombositopeni (%84) ve anemi (%72) olarak saptanmıştır. Olguların %8'i ciddi seyirli sıtma olgusu olmakla birlikte ölümle sonuçlanan olgu görülmemiştir.Sonuç: Son yıllarda ülkemizden bildirilen importe sıtma olgu sayısındaki artışa rağmen bölgemizde bu sayıda düşüş olduğu görülmektedir. Ülkemiz importe sıtma olgularının en sık görüldüğü ülkeler arasında yer aldığından, ateş yüksekliği ve trombositopeni ile başvuran olgularda sıtmanın endemik olduğu bir bölgeye seyahat öyküsü olup olmadığı sorgulanmalıdır.

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Prevalence and Clinical Manifestations of Malaria in Aligarh, India

Cited by 21 publications

References 22 publications

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

Serum Lipids and Lipoproteins During Uncomplicated Malaria: A Cohort Study in Lambaréné, Gabon

A Study of Sodium and Potassium on Disturbances in Malaria at Mangalore, Karnataka, India

Retrospective Analysis of Cases with Imported Malaria in Hatay Province of Turkey: Seventy-Five Cases in Ten Years

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