Prevalence and clinical manifestation of Borrelia miyamotoi in Ixodes ticks and humans in the northern hemisphere: a systematic review and meta-analysis

Hoornstra, Dieuwertje; Azagi, Tal; Eck, Jacqueline A van; Wagemakers, Alex; Koetsveld, Joris; Spijker, René; Platonov, Alexander E.; Sprong, Hein; Hovius, Joppe W.

doi:10.1016/s2666-5247(22)00157-4

Cited by 22 publications

(39 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Borrelia miyamotoi is an emerging tick-borne pathogen of the relapsing fever Borrelia (RFB) group and shares its Ixodes vector with other tick-borne pathogens, including Borrelia burgdorferi sensu lato , tick-borne encephalitis virus, Anaplasma phagocytophilum , and Ehrlichia and Babesia species ( 1 – 6 ). The B. miyamotoi infection rate ranges from 0.7 to 2.8% in the main questing vectors Ixodes scapularis , I. pacificus , I. ricinus , and I. persulcatus ( 7 – 9 ). B. miyamotoi causes an acute febrile illness and flu-like symptoms in immunocompetent patients, referred to as Borrelia miyamotoi disease (BMD), and a meningoencephalitis in immunocompromised individuals ( 10 – 14 ).…”

Section: Introductionmentioning

confidence: 99%

“… B. miyamotoi causes an acute febrile illness and flu-like symptoms in immunocompetent patients, referred to as Borrelia miyamotoi disease (BMD), and a meningoencephalitis in immunocompromised individuals ( 10 – 14 ). To date, hundreds of well-described disease cases have been published in Asia, North America, and Europe ( 9 ). Nevertheless, the burden of infection and disease remains unknown, due to low awareness among the general public and physicians, a noncharacteristic and possibly self-limiting clinical presentation, and, importantly, limited diagnostic tools ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi

et al. 2022

View full text Add to dashboard Cite

This paper describes the protein array as a novel serological test for the diagnosis of Borrelia miyamotoi disease (BMD), by reporting the methodology, the development of a diagnostic algorithm, and its extensive validation. With rising numbers of ticks and tick bites, tick-borne diseases, such as BMD, urgently deserve further societal and medical attention. B. miyamotoi is prevalent in Ixodes ticks across the northern hemisphere.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Microscopy can confirm infection with a Borrelia species, however it cannot be used to distinguish between species and has low sensitivity [30]. In order to see spirochetes in a blood smear or CSF sample, the density needs to be greater than 10 4 cells/mL [11,27]. During the acute phase of BMD, usually within a few days of symptom onset, spirochete density in the blood ranges from 10 1 -10 5 cells/mL [31].…”

Section: Microscopymentioning

confidence: 99%

“…Though ampicillin, azithromycin, and vancomycin, or a combination thereof, have been used to treat BMD. Antibiotic treatment engenders a full recovery with rare cases of persistent fatigue [21,27]. A systematic review and meta-analysis by Hoornstra et al affirmed that doxycycline is the preferred treatment for adults presenting with no neurological complications, and ceftriaxone is the preferred treatment for adults with BMD-associated meningoencephalitis [27].…”

Section: Introductionmentioning

confidence: 99%

“…Antibiotic treatment engenders a full recovery with rare cases of persistent fatigue [21,27]. A systematic review and meta-analysis by Hoornstra et al affirmed that doxycycline is the preferred treatment for adults presenting with no neurological complications, and ceftriaxone is the preferred treatment for adults with BMD-associated meningoencephalitis [27]. Research has confirmed in vitro that both clinical and tick isolates of B. miyamotoi are susceptible to doxycycline, ceftriaxone, and azithromycin, but show resistance to amoxicillin [28].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relapsing Review: A Research Update on <em>Borrelia miyamotoi</em>

Cleveland¹,

Anderson²,

Brissette³

2022

Preprint

View full text Add to dashboard Cite

Borrelia miyamotoi is an emerging tick-borne pathogen in the Northern hemisphere and is the causative agent of Borrelia miyamotoi disease (BMD). B. miyamotoi is vectored by the same hard-bodied ticks as Lyme disease Borrelia, yet phylogenetically groups with relapsing fever Borrelia, and thus has been uniquely labeled a hard tick-borne relapsing fever Borrelia. Burgeoning research has uncovered new aspects of B. miyamotoi in human patients, nature, and the lab. Of particular interest are novel findings on disease pathology, prevalence, diagnostic methods, ecological maintenance, transmission, and genetic characteristics. Herein we review recent literature on B. miyamotoi, discuss how findings adapt to current Borrelia doctrines, and briefly consider what remains unknown about B. miyamotoi.

show abstract

Ticks and spirochetes of the genus Borrelia in urban areas of Central-Western Poland

Ciebiera,

Grochowalska,

Łopińska

et al. 2024

Exp Appl Acarol

View full text Add to dashboard Cite

Due to the extensive use of green urban areas as recreation places, city residents are exposed to tick-borne pathogens. The objectives of our study were (i) to determine the occurrence of ticks in urban green areas, focussing on areas used by humans such as parks, schools and kindergartens, and urban forests, and (ii) to assess the prevalence of Borrelia infections in ticks in Zielona Góra, a medium-sized city in western Poland. A total of 161 ticks representing the two species Ixodes ricinus (34 males, 51 females, 30 nymphs) and Dermacentor reticulatus (20 males, 26 females) were collected from 29 of 72 (40.3%) study sites. In total, 26.1% of the ticks (85.7% of I. ricinus and 14.3% of D. reticulatus) yielded DNA of Borrelia. The difference in the infection rate between I. ricinus and D. reticulatus was significant. Among infected ticks, the most frequent spirochete species were B. lusitaniae (50.0%) and B. afzelii (26.2%), followed by B. spielmanii (9.5%), B. valaisiana (7.1%), B. burgdorferi sensu stricto, (4.8%) and B. miyamotoi (2.4%). No co-infections were found. We did not observe a correlation in the occurrence of Borrelia spirochetes in ticks found in individual study sites that differed in terms of habitat type and height of vegetation. Our findings demonstrate that the Borrelia transmission cycles are active within urban habitats, pointing the need for monitoring of tick-borne pathogens in public green areas. They could serve as guidelines for authorities for the proper management of urban green spaces in a way that may limit tick populations and the potential health risks posed by tick-borne pathogens.

show abstract

Prevalence and clinical manifestation of Borrelia miyamotoi in Ixodes ticks and humans in the northern hemisphere: a systematic review and meta-analysis

Cited by 22 publications

References 66 publications

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi

Development and Validation of a Protein Array for Detection of Antibodies against the Tick-Borne Pathogen Borrelia miyamotoi

Relapsing Review: A Research Update on <em>Borrelia miyamotoi</em>

Ticks and spirochetes of the genus Borrelia in urban areas of Central-Western Poland

Contact Info

Product

Resources

About