Prevalence and clinical impact of antiretinal antibodies in uveitis

Berge, J; Schreurs, Marco W. J.; Vermeer, Jacolien; Meester-Smoor, Magda A.; Rothová, Aniki

doi:10.1111/aos.12939

Cited by 33 publications

(37 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AAbs against four glycolytic enzymes: aldolase (ALDO), α-enolase (ENO1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and pyruvate kinase M2 (PKM2) are particularly prevalent in sera of patients with autoimmune retinopathies, including cancer-associated retinopathy (CAR) and melanoma-associated retinopathy (MAR). Similar AAbs were also reported in autoimmune uveitis (22, 23). Although anti-enolase and other enzymes can be detected in low titers in some healthy individuals (from 0 to 10% depending on population studied), they were likely generated in response to common infections (18, 24).…”

Section: Introductionsupporting

confidence: 85%

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

Adamus

2017

Front. Immunol.

View full text Add to dashboard Cite

Autoantibodies (AAbs) against glycolytic enzymes: aldolase, α-enolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase are prevalent in sera of patients with blinding retinal diseases, such as paraneoplastic [cancer-associated retinopathy (CAR)] and non-paraneoplastic autoimmune retinopathies, as well as in many other autoimmune diseases. CAR is a degenerative disease of the retina characterized by sudden vision loss in patients with cancer and serum anti-retinal AAbs. In this review, we discuss the widespread serum presence of anti-glycolytic enzyme AAbs and their significance in autoimmune diseases. There are multiple mechanisms responsible for antibody generation, including the innate anti-microbial response, anti-tumor response, or autoimmune response against released self-antigens from damaged, inflamed tissue. AAbs against enolase, GADPH, and aldolase exist in a single patient in elevated titers, suggesting their participation in pathogenicity. The lack of restriction of AAbs to one disease may be related to an increased expression of glycolytic enzymes in various metabolically active tissues that triggers an autoimmune response and generation of AAbs with the same specificity in several chronic and autoimmune conditions. In CAR, the importance of serum anti-glycolytic enzyme AAbs had been previously dismissed, but the retina may be without pathological consequence until a failure of the blood–retinal barrier function, which would then allow pathogenic AAbs access to their retinal targets, ultimately leading to damaging effects.

show abstract

Section: Introductionsupporting

confidence: 85%

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

Adamus

2017

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Proof for the definitive diagnosis of (n)pAIR is still missing and even the presence of ARAs is not specific for (n)pAIR, which has been illustrated by the finding of ARAs in control groups and healthy individuals. [8, 51, 52]…”

Section: Discussionmentioning

confidence: 99%

Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy

et al. 2016

Self Cite

View full text Add to dashboard Cite

PurposeAlthough multiple serum antiretinal autoantibodies (ARAs) have been reported in patients with paraneoplastic and non-paraneoplastic autoimmune retinopathy ((n)pAIR), not all retinal antigens involved in (n)pAIR are specified. This study aims to serologically identify patients with presumed (n)pAIR through determination of both known and unknown ARAs by autoantibody profiling.MethodsAn antigen suspension bead array using 188 different antigens representing 97 ocular proteins was performed to detect ARAs in serum samples of patients with presumed (n)pAIR (n = 24), uveitis (n = 151) and cataract (n = 21). Logistic regressions were used to estimate the associations between ocular antigens and diagnosis. Validation of interphotoreceptor matrix proteoglycan 2 (IMPG2) and recoverin antigens was performed by immunohistochemistry and immunoblot, respectively.ResultsSamples of patients with presumed (n)pAIR exhibited a broad spectrum of ARAs. We identified retinal antigens that have already been described previously (e.g. recoverin), but also identified novel ARA targets. Most ARAs were not specific for (n)pAIR since their presence was also observed in patients with cataract or uveitis. High titers of autoantibodies directed against photoreceptor-specific nuclear receptor and retinol-binding protein 3 were more common in patients with presumed (n)pAIR compared to uveitis (p = 0.015 and p = 0.018, respectively). The presence of all other ARAs did not significantly differ between groups. In patients with presumed (n)pAIR, anti-recoverin autoantibodies were the most prevalent ARAs. Validation of bead array results by immunohistochemistry (anti-IMPG2) and immunoblot (anti-recoverin) showed concordant results in (n)pAIR patients.ConclusionsPatients with (n)pAIR are characterized by the presence of a broad spectrum of ARAs. The diagnosis of (n)pAIR cannot be based on the mere presence of serum ARAs, as these are also commonly present in uveitis as well as in age-related cataract patients.

show abstract

“…All patients underwent Quanti-FERON-Tb Gold (QFT; Cellestis Inc., Carnegie, Australia). Screening for the presence of ANA using HEp-2 cells (Inova, San Diego, CA, USA) and the presence of ARA using primate retinal tissue (Euroimmun, Lubeck, Germany) was performed by indirect immunofluorescence as described before (Ten Berge et al 2016). Logistic regressions with correction for age and gender were performed using SPSS (Version 23.0, Armonk, NY: IBM Corp) to analyse differences in the presence of ANA and ARA between the diagnosis groups.…”

Section: Referencesmentioning

confidence: 99%

Antinuclear and antiretinal antibodies in uveitis associated with active and latent tuberculosis

Nora

Berge

Rothová

et al. 2018

Acta Ophthalmologica

Self Cite

View full text Add to dashboard Cite

Prevalence and clinical impact of antiretinal antibodies in uveitis

Cited by 33 publications

References 21 publications

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

Serum Autoantibody Profiling of Patients with Paraneoplastic and Non-Paraneoplastic Autoimmune Retinopathy

Antinuclear and antiretinal antibodies in uveitis associated with active and latent tuberculosis

Contact Info

Product

Resources

About