Prevalence and clinical features of multiple sclerosis in Latin America

Ojeda, Ernesto; Díaz-Cortes, Diana; Rosales, Dominique; Duarte-Rey, Carolina; Anaya, Juan Manuel; Rojas-Villarraga, Adriana

doi:10.1016/j.clineuro.2012.11.028

Cited by 18 publications

(10 citation statements)

References 59 publications

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“…Relapsing-remitting multiple sclerosis (RRMS) is a chronic, immune-mediated demyelinating disease of the central nervous system that frequently involves the visual pathways, usually in the form of optic neuritis (ON) [ 1 ]. Postmortem analysis revealed optic nerve lesions in 94–99% of RRMS patients, even in the absence of a clinical history of ON [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

González-López

Rebolleda

Leal

et al. 2014

BioMed Research International

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Objective. To estimate sensitivity and specificity of several optical coherence tomography (OCT) measurements for detecting retinal thickness changes in patients with relapsing-remitting multiple sclerosis (RRMS), such as macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with Cirrus (OCT) and peripapillary retinal nerve fiber layer (pRNFL) thickness measured with Cirrus and Spectralis OCT. Methods. Seventy patients (140 eyes) with RRMS and seventy matched healthy subjects underwent pRNFL and GCIPL thickness analysis using Cirrus OCT and pRNFL using Spectralis OCT. A prospective, cross-sectional evaluation of sensitivities and specificities was performed using latent class analysis due to the absence of a gold standard. Results. GCIPL measures had higher sensitivity and specificity than temporal pRNFL measures obtained with both OCT devices. Average GCIPL thickness was significantly more sensitive than temporal pRNFL by Cirrus (96.34% versus 58.41%) and minimum GCIPL thickness was significantly more sensitive than temporal pRNFL by Spectralis (96.41% versus 69.69%). Generalised estimating equation analysis revealed that age (P = 0.030), optic neuritis antecedent (P = 0.001), and disease duration (P = 0.002) were significantly associated with abnormal results in average GCIPL thickness. Conclusion. Average and minimum GCIPL measurements had significantly better sensitivity to detect retinal thickness changes in RRMS than temporal pRNFL thickness measured by Cirrus and Spectralis OCT, respectively.

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Section: Introductionmentioning

confidence: 99%

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

González-López

Rebolleda

Leal

et al. 2014

BioMed Research International

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“…We find that global ancestry estimates partly account for the observed ON presentation in Hispanics with MS and could be responsible for the predominant observation of optic nerve and motor involvement in MS across Hispanics in the United States and Latin America . However, sex and age of onset had less of an effect on the risk of ON as a first symptom of MS. Of note, because not all patients presenting with ON will go on to develop MS, our results suggest more broadly that studies of ON in non‐MS cohorts may benefit from studies of admixed populations.…”

Section: Discussionmentioning

confidence: 76%

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis

Amezcua

Beecham

Delgado

et al. 2018

Ann Clin Transl Neurol

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Background and ObjectiveHispanics with multiple sclerosis (MS) present younger and more often with optic neuritis (ON) as compared to Whites in the western United States. Regional differences related to Hispanic genetic admixture could be responsible. We investigated the association between global genetic ancestry and ON and age at onset of MS in Hispanics.MethodsData were obtained for 1033 self‐identified Hispanics with MS from four MS‐based registries from four academic institutions across the United States January 2016–April 2017. Multivariate regression models, utilizing genetic ancestry estimates for Native American (NA), African, and European ancestry, were used to assess the relationship between genetic ancestry and ON presentation and age of MS onset, defined as age at first symptom.ResultsGenetic ancestry and ON proportions varied by region where NA ancestry and ON proportions were highest among Hispanics in the southwestern United States (40% vs. 19% overall for NA and 38% vs. 25% overall for ON). A strong inverse correlation was observed between NA and European ancestry (r = −0.83). ON presentation was associated with younger age of onset (OR: 0.98; 95% CI: 0.96–0.99; P = 7.80 × 10−03) and increased NA ancestry (OR: 2.35 for the highest versus the lowest quartile of NA ancestry; 95% CI: 1.35–4.10; P = 2.60 × 10−03). Younger age of onset was found to be associated with a higher proportion NA (Beta: −5.58; P = 3.49 × 10−02) and African ancestry (Beta: −10.07; P = 1.39 × 10−03).InterpretationEthnic differences associated with genetic admixture could influence clinical presentation in Hispanics with MS; underscoring the importance of considering genetic substructure in future clinical, genetic, and epigenetic studies in Hispanics.

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“…En los países latinoamericanos la forma de presentación más frecuente es la recaída-remisión, con síntomas motores como la presentación más común, seguida de neuritis óptica (4).…”

Section: Introductionunclassified

“…El estado de leve discapacidad encontrado en población latina es más prevalente que en otros países, dicha diferencia puede deberse a factores ambientales, relacionados con las técnicas de diagnóstico, estructura socioeconómica y facilidad de acceso a los servicios de salud (4).…”

Section: Introductionunclassified

Estado actual de la esclerosis múltiple en Colombia

Jiménez

2023

Acta Neurol Colomb

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Introducción: Dos estudios epidemiológicos de esclerosis múltiple (EM) la describen como de bajo riesgo en Colombia. Hay, sin embargo, nuevos sistemas de información que permiten una aproximación más precisa. Objetivo:Estimar la prevalencia nacional de EM, así como por regiones del país, y analizar los costos de los fármacos usados en Colombia. Materiales y métodos: Se obtuvieron datos del Registro Individual de Prestación de Servicios de Salud (RIPS), con el código diagnóstico G35X para esclerosis múltiple, tomando los diagnósticos confirmados nuevos y repetidos entre 2009 y 2013, por sexo, grupo etario y departamento. Para el análisis de medicamentos se usó la base de datos Sismed del 2014, incluyendo los fármacos disponibles en Colombia: interferón beta-1A, interferón beta-1B, acetato de glatiramer, natalizumab, fingolimod y mitoxantrona. Resultados:Según los RIPS, en Colombia se atendieron, en el período 2009-2013, un total de 3.462 personas con diagnóstico de esclerosis múltiple. La prevalencia nacional para el período fue de 7,52/100.000, con las cifras más altas en Bogotá (16,25), donde se atendieron 1.213 pacientes, seguido de los departamentos del Quindío (13,03) y Risaralda (11,18). La mayor proporción de pacientes se encuentra entre los 50 y 54 años de edad, y las mujeres representan más del 70%. Adicionalmente, en 2014 se invirtieron 86.000 millones de pesos (43 millones de dólares) en medicamentos para esclerosis múltiple, lo que equivale a cerca de 25 millones por paciente.

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Prevalence and clinical features of multiple sclerosis in Latin America

Cited by 18 publications

References 59 publications

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Comparative Diagnostic Accuracy of Ganglion Cell-Inner Plexiform and Retinal Nerve Fiber Layer Thickness Measures by Cirrus and Spectralis Optical Coherence Tomography in Relapsing-Remitting Multiple Sclerosis

Native ancestry is associated with optic neuritis and age of onset in hispanics with multiple sclerosis

Estado actual de la esclerosis múltiple en Colombia

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