Prevalence and clinical demography of hyperhomocysteinemia in Han Chinese patients with schizophrenia

Yang, Yating; Wang, Juan; Xiong, Zu-lun; Yao, Xianhu; Ning, Xiaoshuai; Zhong, Yi; Liu, Zhiwei; Zhang, Yelei; Zhao, Tuanjie; Xia, Lei; Zhang, Kai; Liu, Huanzhong

doi:10.1007/s00406-020-01150-x

Cited by 15 publications

(21 citation statements)

References 43 publications

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“…This is because many studies -both by Di Lorenzo et al [48] and Ayesa-Arriola et al [49] have shown a relationship between the occurrence of schizophrenia with an increased level of homocysteine and a decreased level of folic acid. Based on the study by Trześniowska-Drukała et al [53], it was proved that hyperhomocysteinemia was more frequent in patients with schizophrenia (34.4%) compared to the group of healthy people, which was consistent with the study by Yang et al [54] carried out a year later, as well as the study by Sumiao Zhou et al [55] from the current 2021. Moreover, people with comorbid schizophrenia and hyperhomocysteinemia had worse results on tests measuring cognitive functions.…”

Section: The Importance Of Homocysteine In the Development And Course Of Schizophreniasupporting

confidence: 80%

“…Moreover, people with comorbid schizophrenia and hyperhomocysteinemia had worse results on tests measuring cognitive functions. A 2020 study [54] included 330 schizophrenic patients and 190 healthy controls. In patients with schizophrenia, the incidence of hyperhomocysteinemia was 55.05%, while in healthy subjects it was 26.98%.…”

Section: The Importance Of Homocysteine In the Development And Course Of Schizophreniamentioning

confidence: 99%

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When should a psychiatrist remember to test homocysteine levels? - a literature review

Nowak

Chiriboga

Halczuk

et al. 2021

Current Problems of Psychiatry

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Introduction: Homocysteine is an endogenous sulfur amino acid, formed as a result of biochemical changes in methionine. The normal concentration of homocysteine in healthy people is within the range of 5 – 15 μmol / l, and values above 15 μmol / l are referred to as hyperhomocysteinemia. Moreover, it has been shown that the level of homocysteine may be associated with the occurrence of mental disorders. The aim of this article was to search for a relationship between the level of this amino acid and the incidence and prognosis of bipolar disorder, depression, anxiety disorders, schizophrenia or Alzheimer's disease. Material and method: For the review of the literature, available articles from the PubMed database and Google Scholar were used under the following keywords: homocysteine, depression, bipolar disorder, schizophrenia, Alzheimer's disease in the period from 1992 to 2021. Results: The research conducted so far shows that there is a significant correlation between elevated levels of homocysteine and the above-mentioned mental disorders. Conclusion: In order to prevent the consequences of the increased level of homocysteine, its concentration in blood serum should be monitored periodically and appropriate treatment should be implemented in case of abnormal results. It is important to educate patients about the consequences of hyperhomocysteinemia i.a. atherosclerosis, stroke, ischemic heart disease, osteoporosis, neural tube defects, mental disorders and neurodegenerative diseases. It should be also established a strategy to lower the level of this amino acid through lifestyle changes, as well as the supply of folic acid, vitamins B12, B6, B2, N-acetylcysteine and betaine.

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Section: The Importance Of Homocysteine In the Development And Course Of Schizophreniasupporting

confidence: 80%

Section: The Importance Of Homocysteine In the Development And Course Of Schizophreniamentioning

confidence: 99%

When should a psychiatrist remember to test homocysteine levels? - a literature review

Nowak

Chiriboga

Halczuk

et al. 2021

Current Problems of Psychiatry

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“…This is consistent with the rationale above that SGAs likely affect different receptor systems based on the dose used, and may have therapeutic properties for anxiety and depression at lower doses. In contrast, based on data from multiple studies, chlorpromazine equivalents for people with schizophrenia were mostly greater than 400 mg/day [33][34][35]. When looking at specific antipsychotics in our sample, this principle held up.…”

Section: Discussionmentioning

confidence: 75%

Off-label use of antipsychotic medications in psychiatric inpatients in China: a national real-world survey

et al. 2021

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Background The off-label use of antipsychotic medications is common in many countries, and the extent of such use in psychiatric inpatients in China has not been sufficiently studied. The purpose of this study was to survey the incidence and examine the correlates of off-label antipsychotic use in a large, nationally–representative sample in China. Methods This study included discharged psychiatric patients between March 19 and 31, 2019 from 41 tertiary psychiatric hospitals across 29 provinces in China. Their socio-demographic and clinical data were collected and analyzed. Results After excluding patients with schizophrenia spectrum disorder or bipolar disorder, 981 patients were included in the analysis. Overall, antipsychotics were prescribed to 63.2% (95%CI 60.2–66.2%) of the sample. Antipsychotics were used in a wide spectrum of psychiatric disorders, with the rate being the highest among patients with dissociative (conversion) disorders (89.9, 95%CI 83.0–94.8%), organic mental disorders (81.7, 95%CI 73.1–88.7%), dementia (79.0,95%CI 67.8–87.9%), obsessive-compulsive disorder (77.8, 95%CI 55.7–92.5%), mental disorders due to psychoactive substances (75.3,95%CI 64.7–84.2%), behavioural and emotional disorders with onset usually occurring in childhood and adolescence (71.4, 95%CI 45.5–90.1%), somatoform disorders (63.2, 95%CI 40.8%–82..2%), major depression disorder (53.7,95%CI 48.8–58.6%), anxiety disorder (38.8,95%CI 30.5–47.7%), and insomnia (25.0, 95%CI 8.5–28.9%). The top three most commonly used antipsychotics were olanzapine (29.1%), quetiapine (20.3%) and risperidone (6.8%), and their corresponding average doses were 9.04 ± 5.80 mg/day, 185.13 ± 174.72 mg/day, and 2.98 ± 1.71 mg/day, respectively. A binary logistic regression showed that younger age, having the Employee Health Insurance or Residents Health Insurance, having psychotic symptoms and requiring restraint during hospitalization were significantly associated with off-label use of antipsychotics. Conclusion Off-label use of antipsychotics is very common in psychiatric inpatients in China, mainly with moderate-dose use of single agents. However, the efficacy and safety of this practice is uncertain for many diagnoses and for the elderly. Clinicians should be cautious about this practice while waiting for more research data.

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“…The PANSS scale was assessed by a senior psychiatrist at baseline and 12 weeks after drug therapy, and the intra-class correlation coefficient between the four raters was greater than 0.8. The procedure of PANSS assessment was performed as previously reported 15 , 16 .…”

Section: Methodsmentioning

confidence: 99%

ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients

Chen

et al. 2020

Sci Rep

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The objective of this study was to investigate the expression and clinical role of ATP-binding cassette transporter 13 (ABCA13) gene previously shown to be associated with schizophrenia (SZ) through Genome-wide association studies studies. Thirty-two first-episode drug-naive SZ patients and forty-eight age and gender-matched healthy controls were enrolled in this study. We measured ABCA13 mRNA expression levels using quantitative real-time PCR at baseline and 12 weeks after antipsychotic therapy. Moreover, clinical symptoms were measured by the Positive and Negative Syndrome Scale (PANSS) at baseline and 12-week follow-up. We found that ABCA13 mRNA levels were significantly lower in SZ patients compared with healthy controls at baseline. SZ patients’ symptoms were decreased, but ABCA13 mRNA levels were increased after 12 weeks antipsychotic therapy. In addition, there was a significant difference in ABCA13 mRNA levels among SZ patients at baseline and 12-week follow-up. The ABCA13 mRNA levels were not associated with age, BMI, years of education. Of the clinical symptoms measured, the ABCA13 mRNA levels were negatively associated with the PANSS scores at baseline and 12-week follow-up. The results indicated that the ABCA13 mRNA expression level is of interest, and upon further studies, it could be used as a biomarker for SZ treatment outcome.

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Prevalence and clinical demography of hyperhomocysteinemia in Han Chinese patients with schizophrenia

Cited by 15 publications

References 43 publications

When should a psychiatrist remember to test homocysteine levels? - a literature review

When should a psychiatrist remember to test homocysteine levels? - a literature review

Off-label use of antipsychotic medications in psychiatric inpatients in China: a national real-world survey

ATP-binding cassette transporter 13 mRNA expression level in schizophrenia patients

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