Prevalence and Clinical Characteristics of Norovirus Gastroenteritis Among Hospitalized Children in Spain

Junquera, C. Gutiérrez; Baranda, Caridad Sainz de; Mialdea, O. García; Serrano, Elena; Sánchez-Fauquier, Alicia

doi:10.1097/inf.0b013e318197c3ca

Cited by 63 publications

(51 citation statements)

References 24 publications

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“…In Korea, a similar change in the prevalence of rotaviral gastroenteritis is recently emerging as an important cause of severe gastroenteritis in childhood 22) and has been detected at rates varying between 3% and 30% of hospitalized children, both in developed and developing countries [23][24][25] . In this study, only one of all specimens was positive for norovirus, which contradicts previous descriptions in Europe 26,27) . Such variation could be due to different hygienic conditions, different surveillance systems, or to different methods used in diagnostic laboratories in different countries 24) .…”

Section: Discussioncontrasting

confidence: 55%

Prevalence of Viruses with Diarrhea among Hospitalized Children West Gyeonggi Province

Seo

Jung

Kim

et al. 2012

Korean J Pediatr Infect Dis

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Section: Discussioncontrasting

confidence: 55%

Prevalence of Viruses with Diarrhea among Hospitalized Children West Gyeonggi Province

Seo

Jung

Kim

et al. 2012

Korean J Pediatr Infect Dis

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“…These results are consistent with recent studies that describe RV as the most prevalent and NoV as the second most important viral agent causing gastroenteritis in children (RV 16.6-71.4%; NoV 12-17.3%). [31][32][33][34][35] The NoV and SaV prevalence determined in the current study is higher than previously estimated in the same region, 17 which could be attributed to the more sensitive realtime RT-PCR detection method applied. NoVs were detected only in children up to 2 years old (median age 8 months), which is in agreement with studies in Brazil and Nicaragua where more frequent NoV infections in children ≤2 years old were reported.…”

Section: Discussioncontrasting

confidence: 52%

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Mans

Villiers

Plessis

et al. 2010

Journal of Clinical Virology

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a b s t r a c tBackground: Noroviruses (NoVs) are important enteric pathogens that cause gastroenteritis worldwide. The first documented NoV outbreaks in South Africa (SA) were described in 1993. The current NoV prevalence and circulating genotypes are unknown. SA lacks NoV outbreak reporting systems and therefore the number and impact of NoV infections is underestimated. Objectives: This study aimed to determine the prevalence and genetic diversity of NoV infections in hospitalised paediatric patients with gastroenteritis in SA during 2008. Study design: Stool specimens referred for virological analysis from hospitalised children ≤13 years, with gastroenteritis, were screened for rotavirus, human adenovirus and human astrovirus by enzyme immunoassay and for NoV genogroup I (GI), II (GII) and sapovirus by real-time RT-PCR. NoV strains were genotyped, and variants identified, based on sequence and phylogenetic analyses of the 5 end or the full length of the capsid gene, respectively. Results: Rotavirus was the most prevalent virus detected in 24.2% (61/252) of specimens, followed by NoV in 14.3% (35/245) and adenovirus, astrovirus and sapovirus in 9.6%, 6.7% and 4% of specimens, respectively. NoVs were only detected in children ≤2 years. The GII NoVs (89%) predominated and eight types were identified with GII.4 (43%) detected most frequently. The emerging 2008 GII.4 variant represented 80% of the GII.4 strains. Conclusions: A diverse range of NoV genotypes were identified in hospitalised children with gastroenteritis. The 2008 GII.4 variant was the most frequently detected strain in the study. This is the first report of NoV GII.4 viruses in SA.

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“…The importance of these four viral agents as a cause of gastroenteritis outbreaks is well documented, but their role in sporadic acute severe gastroenteritis responsible for hospitalization or nosocomial infections remains to be assessed in developed countries (7,8). The aim of this study was to determine the prevalence and the seasonal distribution of the aforementioned viruses in clinically relevant (i.e., hospitalizationrequiring) infantile gastroenteritis and to assess the prevalence of nosocomial infections.…”

mentioning

confidence: 99%

“…In children, group A rotavirus (RV) is the major etiologic agent of viral gastroenteritis and is responsible for 29 to 45% of hospitalizations worldwide (13,14). Recent work has showed that noroviruses are the second most frequent etiologic agents of viral gastroenteritis in children (6,7). Data on the relative significances of the other agents as pediatric pathogens depend on variants such as the diagnostic assay and the geographical setting chosen (9,12,18,19).…”

mentioning

confidence: 99%

Prevalence of Rotavirus, Adenovirus, Norovirus, and Astrovirus Infections and Coinfections among Hospitalized Children in Northern France

et al. 2010

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stool specimens were prospectively collected from children hospitalized for gastroenteritis signs or from neonates and premature cases who were born in two French hospital settings in the north of France. They were tested by rapid enzyme immunoassay (EIA) analyses for rotavirus and adenovirus and by two commercially available ELISA tests for the detection of norovirus and astrovirus. The overall rates of prevalence for rotavirus, norovirus, adenovirus, and astrovirus were 21, 13, 5, and 1.8%, respectively, and they did not significantly differ between the two hospital settings (P ‫؍‬ 0.12). Mixed virus infections were detected in 32 (3.3%) of the 973 study children and were associated with norovirus in 21 (66%) infants, including 5 premature cases. From fall to spring, norovirus infections accounted for 52% of documented gastroenteritidis viral infections at a time when rotavirus was epidemic, resulting in mixed norovirus and rotavirus gastrointestinal tract infections. Of the 367 documented viral gastroenteritis cases, 15 (4.1%) were identified as nosocomial infections, 5 of which occurred in premature cases. These findings highlight the need to implement norovirus and astrovirus ELISA detection assays in association with rapid EIA rotavirus and adenovirus detection assays for the clinical diagnosis and the nosocomial prevention of gastroenteritis viral infections in pediatric departments.

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Prevalence and Clinical Characteristics of Norovirus Gastroenteritis Among Hospitalized Children in Spain

Abstract: Norovirus was a frequent cause of acute severe sporadic gastroenteritis in children representing the second etiologic agent after rotavirus.

Cited by 63 publications

References 24 publications

Prevalence of Viruses with Diarrhea among Hospitalized Children West Gyeonggi Province

Prevalence of Viruses with Diarrhea among Hospitalized Children West Gyeonggi Province

Emerging norovirus GII.4 2008 variant detected in hospitalised paediatric patients in South Africa

Prevalence of Rotavirus, Adenovirus, Norovirus, and Astrovirus Infections and Coinfections among Hospitalized Children in Northern France

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