Prevalence and Clinical Characteristics of Hidradenitis Suppurativa Phenotypes in a Large Dutch Cohort

Drug Survival of Oral Retinoids in Hidradenitis Suppurativa: A Real-Life Cohort Study

“…The patient data were extracted from electronic patient files: sex, age at onset of HS symptoms, age at start of retinoid treatment, body mass index (BMI) at start of treatment, smoking status at start of treatment, comorbidities, previous or active acne vulgaris or pilonidal cyst, family history of HS, presence of widespread comedones, phenotype, and the treating center. Phenotypes were categorized as previously published, and stratified accordingly to the regular type, frictional furuncle type, scarring folliculitis type, and conglobata type [ 9 , 15 ]. Both phenotype and presence of widespread comedones were assessed based on photographic images by three physicians trained in the field of HS (KB, PA, KD) who were blinded to treatment.…”

“…Various phenotype classifications have been proposed in HS [ 6 – 8 ]. In this manuscript, we utilize the phenotype classification refined by Dudink et al that encompasses the following phenotypes: the frictional furunculoid, conglobata, scarring folliculitis, and regular types, each with their own predilection sites and hallmark lesions [ 9 ].…”

Können Acne‐inversa‐Patienten ihre Läsionen mit Hilfe eines digitalen Läsionsidentifikationsschemas klassifizieren?

“…6 Im Jahr 2022 publizierte dieselbe Gruppe ihren Vorschlag, dass die Typen ectopic und syndromic keine spezifischen klinischen Merkmale aufweisen und als einer der anderen Phänotypen kategorisiert werden sollten. 11 Klinische Erfahrungen deuten auf eine Variabilität in der Läsionspräsentation und ein potenziell Phänotyp-abhängiges Ansprechen auf Therapien hin. Die Identifizierung von Subpopulationen könnte daher das therapeutische Gesamtbild verbessern und das Potenzial für eine stärker personalisierte, maßgeschneiderte Therapie im Ai-Bereich schaffen.…”

Hidradenitis Suppurativa: A Perspective on Genetic Factors Involved in the Disease

“…The above-mentioned scoring systems, however, could not reflect the wider clinical spectrum of HS and the associated comorbidities, especially in the syndromic forms; for these reasons, considering the clinical variability of the disease and the lack of a homogeneous classification, Van der Zee et al [ 28 ] proposed to classify HS in six clinical phenotypes: (i) regular type, which represents the typical lesions described above, (ii) frictional furuncle type, characterized by nodules and abscesses in friction areas (buttocks, legs, and abdomen), which rarely evolve into fistulas, (iii) scarring folliculitis type, in which classical superficial lesions (Hurley stage I) are frequently followed by cribriform scarring and pseudocomedones, (iv) conglobate type, in which cyst formation and acne conglobata predominates on the face and upper back with a strong familiar history, (v) syndromic type in patients with concomitant diseases such as inflammatory bowel disease (IBD), arthritis, and autoinflammatory syndromes, and finally, (vi) ectopic type, in which the main area involved is the face [ 30 ]. Subsequently, Dudnik et al [ 31 ], based on real-life observation on a Dutch cohort of patients, suggested that the ectopic and syndromic phenotypes were not specific, lacking distinctive clinical features and could be categorized as one of the other phenotypes; interestingly, a positive family history did not differ between the phenotypes. Frew et al [ 32 ] assessed the inter-rater reliability of HS phenotypes described in the literature and based on genotype-phenotype correlation and proposed a revision of the classification limiting it into a: (i) typical HS, corresponding to the regular type, (ii) atypical HS, including scarring folliculitis and conglobate types, and (iii) syndromic HS [ 32 ].…”