Prevalence and Clinical Characteristics of Glaucoma in Adult Chinese: A Population-Based Study in Liwan District, Guangzhou

He, Miao; Foster, Paul J.; Ge, Jian; Huang, Wenyong; Zheng, Yingfeng; Friedman, David S.; Lee, Pak Sang; Khaw, PT

doi:10.1167/iovs.06-0051

Cited by 339 publications

(266 citation statements)

References 17 publications

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“…An epidemiological study showed that the prevalence of primary angle-closure glaucoma was much higher in Asia, especially in China, than in other areas. [15][16][17][18] The aim of malignant glaucoma therapy is to relieve the ciliolenticular block, disrupt the misdirection of aqueous humor and to restore normal aqueous flow. 19 Drug therapy induces a posterior movement of the lens-iris diaphragm, reduces the production of aqueous humor, and dehydrates the vitreous volume.…”

Section: Discussionmentioning

confidence: 99%

Clinical efficacy of modified partial pars plana vitrectomy combined with phacoemulsification for malignant glaucoma

Qian

Liu

et al. 2016

Eye

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Objective The objective of this study was to evaluate the clinical effects of modified partial pars plana vitrectomy together with phacoemulsification, intraocular lens (IOL) implantation, posterior capsulectomy, and zonulohyaloidectomy for patients with malignant glaucoma after trabeculectomy or cataract surgery. Design Retrospective, cohort study. Participants Thirty consecutive patients (30 eyes) with malignant glaucoma after trabeculectomy surgery or ultrasonic phacoemulsification of cataract between January 2008 and September 2014 were enrolled. Methods A retrospective analysis of 30 eyes with malignant glaucoma after trabeculectomy surgery for angle-closure glaucoma or ultrasonic phacoemulsification of cataract was performed. All patients underwent modified partial pars plana vitrectomy with zonulohyaloidectomy. Phacoemulsification and IOL implantation was performed in 25 patients with no previous cataract surgery. Preoperative and post-operative ocular parameters were recorded in detail. Main outcome measures Clinical features, anterior chamber depth, best-corrected visual acuity, and intraocular pressure (IOP). Results In these 30 patients, 25 had undergone trabeculectomy surgery and 5 had undergone cataract surgery. The mean axial length was 21.3 ± 0.8 mm. After surgery, mean IOP decreased from 34 ± 8.3 mm Hg to 10.5 ± 4.1 mm Hg (Po0.001), and mean anterior chamber depth increased from 0.8 ± 0.4 mm to 2.7 ± 0.3 mm (Po0.001). No severe complications occurred. Conclusions Modified partial pars plana vitrectomy combined with phacoemulsification, IOL implantation, posterior capsulectomy, and zonulohyaloidectomy not only simplifies the process of traditional vitrectomy, but effectively resolves the ciliary block and corrects the misdirection of aqueous humor in malignant glaucoma.

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Section: Discussionmentioning

confidence: 99%

Clinical efficacy of modified partial pars plana vitrectomy combined with phacoemulsification for malignant glaucoma

Qian

Liu

et al. 2016

Eye

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“…However, as the proportion of angle-closure glaucoma to open-angle glaucoma in the present study was equal to or lower than in other investigations, it may only serve to strengthen that finding. [22][23][24][25][26][27][28] Another limitation of the study is that gonioscopy was performed only for all study participants with glaucoma and all glaucoma suspects. However, as some of the glaucoma suspects were discovered as such first at the occasion of the assessment of the optic disc photographs, which took later than the clinical examination, gonioscopy was not performed for all glaucoma suspects.…”

Section: Discussionmentioning

confidence: 99%

Glaucoma and mortality in the Beijing Eye Study

Wang

Jonas

2008

Eye

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Purpose To assess the relationship between glaucoma and mortality in a population-based setting. Methods At baseline in 2001, the Beijing Eye Study examined 4356 subjects for glaucoma with a detected glaucoma frequency of 135/ 4356 or 3.1%. Mean age was 55.9 ± 10.4 years (40-101 years). In 2006, all study participants were reinvited for a follow-up examination. Results Out of the 4356 subjects, 3208 (73.6%) subjects returned for follow-up examination, while 124 (2.8%) subjects were dead, and 1024 (23.5%) subjects did not agree to be reexamined or had moved away. 26, 4.20). If the whole glaucoma group was differentiated into an open-angle glaucoma group and an angleclosure group, mortality was still significantly associated with age (Po0.001), gender (Po0.001), level of education (Po0.001), and with the presence of angle-closure glaucoma (P ¼ 0.006; OR: 3.09; 95% CI: 1.49, 10.2), while the association with the presence of openangle glaucoma was marginally significant (P ¼ 0.13; OR: 1.83; 95% CI: 0.84, 4.01). Conclusions The data suggest that glaucoma, particularly angle-closure glaucoma, may be associated with an increased rate of mortality in adult Chinese in Greater Beijing.

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“…Additionally, those with more severe forms of angle closure were not included in this study. 12 Including more severe forms of angle closure such as primary angle closure and PACG subjects should increase the sensitivity, specificity, and overall utility of the tools being tested, if causing any change. Lastly SPAC was developed in a Japanese cohort but used in a Chinese population in this study.…”

Section: Discussionmentioning

confidence: 99%

“…12 For this study, a consecutive series of individuals over 50 years of age who had no evidence of angle closure on gonioscopy was selected under a protocol similar to that used in the ZAP trial. Of 90 participants enrolled from the Liwan Eye Study, 72 open-angle participants for whom complete data were recorded were selected to serve as controls.…”

Section: Methodsmentioning

confidence: 99%

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Comparing approaches to screening for angle closure in older Chinese adults

Andrews

Chang

Jiang

et al. 2011

Eye

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Aims Primary angle-closure glaucoma is expected to account for nearly 50% of bilateral glaucoma blindness by 2020. This study was conducted to assess the performance of the scanning peripheral anterior chamber depth analyzer (SPAC) and limbal anterior chamber depth (LACD) as screening methods for angle closure. Methods This study assessed two clinical populations to compare SPAC, LACD, and gonioscopy: the Zhongshan Angle-closure Prevention Trial, from which 370 patients were eligible as closed-angle participants and the Liwan Eye Study, from which 72 patients were selected as open-angle controls. Eligible participants were assessed by SPAC, LACD, and gonioscopy. Results Angle status was defined by gonioscopy. Area under the receiver operating characteristic curve (AUROC) for SPAC was 0.92 (0.89-0.95) whereas AUROC for LACD was 0.94 (0.92-0.97). Using conventional cutoff points, sensitivity/specificity was 93.0%/70.8% for SPAC and 94.1%/87.5% for LACD. Sequential testing using both SPAC and LACD increased the specificity to 94.4% and decreased the sensitivity to 87.0%. Conclusion SPAC has significantly lower specificity than LACD measurement using conventional cutoffs but interpretation of the findings can be performed by modestly trained personnel.

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Prevalence and Clinical Characteristics of Glaucoma in Adult Chinese: A Population-Based Study in Liwan District, Guangzhou

Cited by 339 publications

References 17 publications

Clinical efficacy of modified partial pars plana vitrectomy combined with phacoemulsification for malignant glaucoma

Clinical efficacy of modified partial pars plana vitrectomy combined with phacoemulsification for malignant glaucoma

Glaucoma and mortality in the Beijing Eye Study

Comparing approaches to screening for angle closure in older Chinese adults

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