Prevalence and Characterization of Leukotoxin-Producing
            <i>Staphylococcus intermedius</i>
            in Isolates from Dogs and Pigeons

Futagawa-Saito, Keiko; Sugiyama, Tsukasa; Karube, Sayaka; Sakurai, Naomi; Ba-Thein, William; Fukuyasu, Tsuguaki

doi:10.1128/jcm.42.11.5324-5326.2004

Cited by 62 publications

(65 citation statements)

References 17 publications

(16 reference statements)

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“…The high prevalence of genes Luk S-I (95%), Luk F-I (91%), and SIET (91%) observed in this study is similar to the data from other studies, where 98%, 100%, and 100% of canine isolates were found to be positive for these genes [15,[22][23][24][25]. This high prevalence probably indicates their importance for active infection.…”

Section: Discussionsupporting

confidence: 81%

“…In present study, we observed higher prevalence compared and only hlg ƴ gene showed low frequency [15,[21][22][23]. These discrepancies may be due to the differences in the health status of the animals between studies or due to considerable genetic variability among the isolates; for example, gene sea is more prevalent in pyoderma isolates than those present on healthy skin.…”

Section: Discussionmentioning

confidence: 42%

“…S. pseudintermedius exfoliative toxin SIET and exfoliative toxin EXI possibly play a role in the pathogenesis of cutaneous canine lesions and chronic otitis [13,14]. S. intermedius produces a bicomponent leukotoxin (Luk-I) similar to Panton-Valentine Leukocidin (PVL) of S. aureus, which is also encoded by two genes, LukS-I and LukF-I [15].…”

Section: Introductionmentioning

confidence: 99%

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Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Pitchenin

Brandão

Rosa

et al. 2018

J Infect Dev Ctries

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Introduction: Staphylococcus pseudintermedius is coagulase-positive species of the Staphylococcus intermedius group. It is an opportunistic pathogen that can cause infection in various parts of the body and has a zoonotic potential. Although studies on the pathogenicity and epidemiology of S. pseudintermedius are limited, it is known that this bacterium has several virulence factors, including toxins. These toxins can be classified into three main groups: pyrogenic toxins with superantigenic properties such as toxic shock syndrome toxin and staphylococcal enterotoxins, exfoliative toxins, and cytotoxins such as hemolysins and leukocidins. Methodology: In this study, the occurrence of eight toxin genes (sea, sec, tst, SIET, EXI, LuK F-I, Luk S-I, and hlg ƴ) was examined by PCR in 58 isolates of S. pseudintermedius from four domestic animal species. Results: All S. pseudintermedius isolates had at least one of the eight toxin genes. The predominant toxin genes were Luk S-I (95%), Luk F-I (91%), and EXI (91%), and the least prevalent gene was hlg ƴ (5%). Significant association (p = 0.0175) was found between the occurrence patterns of genes hlg ƴ and Luk F-I. Conclusions: The frequent occurrence of these genes in S. pseudintermedius obtained from diseased animals indicates that these toxins may play an important role in the pathogenesis of infection among domestic animals.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 42%

See 1 more Smart Citation

Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Pitchenin

Brandão

Rosa

et al. 2018

J Infect Dev Ctries

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“…delphini was initially isolated from a purulent skin lesions in dolphins (Voraldo et al 1988). Subsequently, this species was also found in a wide range of animals, including horses, mink, domestic pigeons, and recently it was isolated from donkeys (Hesselbarth and Schwarz 1995, Futagawa-Saito et al 2006, Futagawa-Saito et al 2007, Sledge et al 2010, Gharsa et al 2014. The phylogenetic analysis of nuc gene sequences revealed, that this species is formed by two genetically distinct groups (A and B) (Sasaki et al 2007).…”

mentioning

confidence: 99%

Genetic characterization of coagulase-positive staphylococci isolated from healthy pigeons

Kizerwetter-Świda¹,

Chrobak-Chmiel²,

Rzewuska³

et al. 2015

Polish Journal of Veterinary Sciences

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Coagulase-positive staphylococci (CoPS) are opportunistic veterinary pathogens, of which Staphylococcus aureus, S. delphini and S. intermedius can be isolated from pigeons. The biochemical identification of S. delphini and S. intermedius isolates may be incorrect, because of their phenotypic similarity. The purpose of the present study was to isolate and identify CoPS from domestic and feral pigeons and to determine their genetic relatedness by PFGE. A total number of 31 isolates of CoPS were obtained, 15 were identified as S. delphini group B, six as S. aureus, four as S. delphini group A, three as S. intermedius and three as S. schleiferi subsp. coagulans. The results indicate that S. delphini group B is the predominant CoPS species among pigeons studied. PFGE restriction patterns of S. delphini group A and S. delphini group B form separate clusters, demonstrating their genetic heterogeneity. Indistinguishable or very similar PFGE patterns observed among S. delphini group B isolates from domestic and feral pigeons confirm the possibility of CoPS transmission between these birds.

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“…coagulans, and also coagulasenegative Staphylococcus spp. (CoNS), are implicated in the etiology of animal diseases, such as suppurative disease, mastitis, arthritis and urinary tract infection, due to their virulence factors (Futagawa-Saito et al, 2006;Silva et al, 2003). Staphylococcus species are usually resistant to ß-lactams, aminoglycosides and macrolides.…”

mentioning

confidence: 99%

Challenges in predicting Staphylococcus spp. -lactamic resistance in pet animals

Pereira¹,

Motta²,

Rojas³

et al. 2014

Afr. J. Microbiol. Res.

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Prevalence and Characterization of Leukotoxin-Producing Staphylococcus intermedius in Isolates from Dogs and Pigeons

Cited by 62 publications

References 17 publications

Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Occurrence of toxin genes in Staphylococcus pseudintermedius from diseased dogs and other domestic and wild species

Genetic characterization of coagulase-positive staphylococci isolated from healthy pigeons

Challenges in predicting Staphylococcus spp. -lactamic resistance in pet animals

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