Prevalence and characteristics of the MMTV-like associated breast carcinomas in Tunisia

Hachana, Mohamed Ridha; Trimèche, Mounir; Ziadi, Sonia; Amara, Khaled; Gaddas, Naim; Mokni, Moncef; Korbi, S.

doi:10.1016/j.canlet.2008.06.001

Cited by 41 publications

(34 citation statements)

References 33 publications

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“…Interestingly, we found a correlation between the presence of JCV and the negativity of expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. Similar correlation was also reported for other viruses that have been related to breast cancer, such as Epstein-Barr virus (EBV) [6] and the MMTV like [20]. Additional studies looking at JCV are needed to clarify the genetic or the epigenetic mechanisms by which JCV interferes with the hormonal receptors expression in breast carcinomas.…”

Section: Discussionsupporting

confidence: 66%

“…No significant differences in overall or disease-free survival rates were seen between patients according to the JCV positivity and negativity. We also assessed the relation between JCV and two others viruses also found positives previously in some breast carcinoma cases in the same Tunisian series, the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like [20]. We found a trend toward an inverse correlation between the presence of JCV and SV40 in breast carcinomas (P = 0.06; Table 1).…”

Section: Clinicopathological Correlationsmentioning

confidence: 78%

“…All cases were selected on the basis of availability of paired frozen samples of breast cancer tissue and matched adjacent normal breast tissue obtained at the time of primary surgery before any treatment. The clinicopathological characteristics and immunohistochemical status of estrogen and progesterone receptors, HER2, and p53 expression of these cases was reported in our previous report [20].…”

Section: Patients and Samplesmentioning

confidence: 79%

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Investigation of human JC and BK polyomaviruses in breast carcinomas

Hachana

Amara

Ziadi

et al. 2011

Breast Cancer Res Treat

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We have previously showed the presence of the simian virus 40 (SV40) and the mouse mammary tumor virus (MMTV)-like in a significant proportions of Tunisian breast carcinomas. However, to date there are no published studies concerning evaluation of the possible implication of the human polyomaviruses JC (JCV) and BK (BKV) in breast carcinomas. The presence of JCV and BKV DNA was investigated by PCR in a 123 primary breast carcinomas and matched adjacent non-tumor breast tissues. The results were correlated to clinicopathological and virological parameters. JCV T-antigen DNA was detected in 23% of breast carcinoma cases; however, all cases were negative for BKV. JCV T antigen PCR products were further confirmed as authentic JCV genome by direct sequencing. JCV was found in invasive ductal carcinomas (28/112 cases) but not in invasive lobular carcinomas (0/5) or medullary carcinomas (0/6). JCV DNA presence correlates inversely with the expression of estrogen (P = 0.022) and progesterone (P = 0.008) receptors. JCV DNA presence correlates also with "triple negative" phenotype (P = 0.021). With regard to virological data, a trend toward an inverse correlation was noted between the presence of JCV and SV40 (P = 0.06). Moreover, significant correlation was found between multiple viral infection (JCV, and/or SV40, and/or MMTV-like in the same tumor) and "triple negative" phenotype (P = 0.001) and also with p53 accumulation (P = 0.028). To the best of our knowledge, this is the first study demonstrating the presence of JCV in a subset of breast carcinomas. Also our results suggest that "triple negative" breast carcinomas are viral-related tumors.

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Section: Discussionsupporting

confidence: 66%

Section: Clinicopathological Correlationsmentioning

confidence: 78%

Section: Patients and Samplesmentioning

confidence: 79%

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Investigation of human JC and BK polyomaviruses in breast carcinomas

Hachana

Amara

Ziadi

et al. 2011

Breast Cancer Res Treat

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“…The detection of MMTV-like env sequences has been reported in variable proportions that did not exceed 40% of BC cases in several countries. However, these viral sequences were found in higher proportion (74%) in Tunisian women diagnosed with BC during the 1970s (Hachana et al 2008).…”

Section: Mouse Mammary Tumor Virus (Mmtv) and Breast Cancermentioning

confidence: 98%

The possible involvement of virus in breast cancer

Amarante

Watanabe

2008

J Cancer Res Clin Oncol

101

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It is well known that the etiology of human breast cancer is significantly affected by environmental factors. Virus-associated cancer refers to a cancer where viral infection results in the malignant transformation of the host's infected cells. Human papillomaviruses (HPV), mouse mammary tumor virus (MMTV) and Epstein-Barr (EBV) virus are prime candidate viruses as agents of human breast cancer. The precise role that viruses play in tumorigenesis is not clear, but it seems that they are responsible for causing only one in a series of steps required for cancer development. The idea that a virus could cause breast cancer has been investigated for quite some time, even though breast cancer could be a hereditary disease; however, hereditary breast cancer is estimated to account for a small percentage of all breast cancer cases. Based on current research, this review present at moment, substantial, but not conclusive, evidence that HPV, EBV and MMTV may be involved in breast cancer.

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“…Although it has been reported that 32-74% of human breast cancer specimens from the USA, Italy, Australia, and Tunisia contained gene sequences homologous to the MMTV env gene [18,19,20,21], it has not been detected in breast cancer specimens from Sweden, Austria, England, Japan, Vietnam, and Mexico [14,20,22,23,24,25]. Also, a significant difference in the prevalence of antibodies reactive with MMTV and breast cancer rates has been reported between women from Western and Eastern countries.…”

Section: Discussionmentioning

confidence: 99%

No Evidence of Mammary Tumor Virus <b><i>env </i></b>Gene-Like Sequences among Iranian Women with Breast Cancer

Oskouee

Shahmahmoodi²,

Jalilvand³

et al. 2014

Intervirology

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Objective: The mouse mammary tumor virus (MMTV) is the well-established etiological agent of mammary tumors in mice. A series of studies have implicated that a human murine mammary tumor virus-like virus occurs in human breast cancer, but it is unclear whether it has any causal role. Methods: The aim of the present study was to investigate the presence of MMTV env gene-like sequences in a group of Iranian women with or without breast cancer. A total of 65 breast cancer and 65 noncancerous breast specimens from the Department of Pathology of Tabriz University in East Azerbaijan, Iran, were analyzed by nested PCR. Results: All breast cancer and benign breast samples were negative for MMTV env gene-like DNA. Conclusion: These results indicate that the MMTV env gene-like virus may not play a significant role in the etiology of breast cancer among Iranian women.

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Prevalence and characteristics of the MMTV-like associated breast carcinomas in Tunisia

Cited by 41 publications

References 33 publications

Investigation of human JC and BK polyomaviruses in breast carcinomas

Investigation of human JC and BK polyomaviruses in breast carcinomas

The possible involvement of virus in breast cancer

No Evidence of Mammary Tumor Virus <b><i>env </i></b>Gene-Like Sequences among Iranian Women with Breast Cancer

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