Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa

Doualla-Bija, Marie; Batchama, Yonathan Lobe; Moutchia-Suh, Jude; Moor, Vicky Jocélyne Ama; Kamdem, Félicité; Lekpa, Fernando Kemta; Namme, Henry Luma

doi:10.1016/j.dsx.2018.06.015

Cited by 8 publications

(11 citation statements)

References 26 publications

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“…Our study´s first result is that MetS is common in Cameroonian patients with gout at the time of diagnosis, where it concerns about 1 in 5 patients. Although it is low compared to the high prevalence previously reported in Cameroon [ 14 ] and elsewhere [ 1 , 18 - 25 ], these findings indicate that the prevalence of the MetS increases substantially with the duration of the disease, increasing levels of SUA, and even with age [ 1 , 18 , 20 ]. As a reminder, data were collected in this study at the time of diagnosis, whereas in the previous study performed in Cameroon the data were collected in patients with gout with a median duration of disease at 7.5 years [ 14 ].…”

Section: Discussionmentioning

confidence: 52%

“…In Cameroon, this prevalence varies from 25% to 32.4%, also with a clear female predominance [ 12 , 13 ]. In this country, about one out of every two gout patients would have a MetS [ 14 ]. These patients with gout and MetS significantly have a higher body mass index (BMI) and higher levels of serum uric acid (SUA).…”

Section: Introductionmentioning

confidence: 99%

“…These patients with gout and MetS significantly have a higher body mass index (BMI) and higher levels of serum uric acid (SUA). Although MetS was more common in women than in men, the difference was not significant [ 14 ]. These results are comparable to those obtained out of Africa [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study

Lekpa¹,

Bebey²,

Bouallo³

et al. 2022

Pan Afr Med J

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Introduction few studies have specifically investigated the link between metabolic syndrome (MetS) and gout in sub-Saharan Africa. This report aimed to evaluate in patients with gout the association between gout at diagnosis and MetS and to assess the gender difference. Methods we performed a single-centre retrospective cohort study on all outpatients seen in the Rheumatology Unit of the General Hospital, Douala, Cameroon. We included records of patients with a recent diagnosis of gout according to the American College of Radiology (ACR) criteria. MetS was defined according to the harmonized criteria. Results we included 511 patients (415 men), with a mean age at diagnosis of 55.9 ±10.8 years. Women were older than men. The mean serum uric acid was 8.24±2.23 mg/L, with hyperuricemia found in 394 patients (77.1%). MetS was present in 101 patients (19.7% [95% CI: 16.8%-22.1%]), significantly more common in men compared to women (23.6% vs. 10.8%; p<0.001). The main components of the MetS were: increased waist circumference (217 patients, 61.3%), obesity (256 patients, 52.2%), hypertension (208 patients, 40.7%), and diabetes mellitus (52 patients, 10.2%). Furthermore, hypertension, diabetes mellitus, obesity, and increased waist circumference were more frequent in women (p<0.001). There was no difference in dyslipidemia according to gender. The combination of components of the MetS was more frequent in men than women (p<0.001). Conclusion MetS are common in newly diagnosed Cameroonian patients with gout, with increased waist circumference, obesity, hypertension and diabetes mellitus being the main components. These components are more common in women, but their combination was more frequent in men.

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Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study

Lekpa¹,

Bebey²,

Bouallo³

et al. 2022

Pan Afr Med J

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“…A study in the sub-Saharan African population showed that roughly one in every two gout patients also had metabolic syndrome. Gout patients with metabolic syndrome had a significantly higher BMI, and had significantly higher levels of serum uric acid levels (Doualla-Bija et al, 2018).…”

Section: Discussionmentioning

confidence: 93%

Risk Factor Analysis for Gout in the Latvian Population

Nagle

Luksa

Moisejevs

et al. 2020

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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Communicated by Aivars LejnieksGout (Gr. podagra) is a multifactorial pathology, which means that both genetic and environmental factors play a role in the aetiology of the disease. For these reasons, revealing risk factors could be of very high importance in prevention and treatment of gout. In the present study, we found that a major role in gout predisposition is played by specific alleles in the ABCG2 gene. The study used survey data for 43 gout patients and 99 healthy control individuals who were genotyped for rs2231142. It was found that allelic variant rs2231142 in the ABCG2 gene had the strongest association with gout. Among other co-factors studied, sex, and increased body mass index were associated with gout.

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“…It should be screened and treated in all patients with metabolic syndrome. The metabolic syndrome is the constellation of at least three of the following elements-Overweight/obesity, hypertension, diabetes, dyslipidemia-with overweight/obesity being a key factor [11]. In our practice, we tend to include hyperuricemia as part of this syndrome because it is highly prevalent this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Cor triatriatum sinister in a 36-Year-old male with Metabolic Syndrome: A case report in sub-Saharan Africa.

Jingi

Mfeukeu-Kuaté

et al. 2021

Preprint

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Prevalence and characteristics of metabolic syndrome in gout patients in a hospital setting in sub-Saharan Africa

Cited by 8 publications

References 26 publications

Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study

Gender difference in the association between gout at diagnosis and metabolic syndrome in African population: a retrospective cohort study

Risk Factor Analysis for Gout in the Latvian Population

Cor triatriatum sinister in a 36-Year-old male with Metabolic Syndrome: A case report in sub-Saharan Africa.

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