Prevalence and characteristics of epilepsy in the Belgian shepherd variants Groenendael and Tervueren born in Denmark 1995–2004

Berendt, Mette; Gulløv, Christina Hedal; Christensen, Stine Louise Krogh; Gudmundsdottir, Hulda; Gredal, Hanne; Fredholm, Merete; Alban, Lis

doi:10.1186/1751-0147-50-51

Cited by 49 publications

(90 citation statements)

References 28 publications

(31 reference statements)

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“…ES can result in the life‐threatening condition of SE. Yet, the prevalence of ES and SE in the hospital population is rarely described in veterinary medicine, and currently only limited data on the prevalence of these conditions are available 20 . In human medicine, between 0.8 and 1% of the human population, respectively, are estimated to suffer from a form of epilepsy during their lives 21,22 .…”

Section: Discussionmentioning

confidence: 99%

Status Epilepticus and Epileptic Seizures in Dogs

Zimmermann¹,

Hülsmeyer²,

Sauter‐Louis

et al. 2009

Veterinary Internal Medicne

100

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Background: A special form of epileptic seizures (ES) is the life-threatening condition of status epilepticus (SE), which requires immediate and specific treatment based on a correct diagnosis of the underlying disease condition.Hypothesis/Objectives: The objectives of this retrospective study were to determine prevalence of ES and SE in dogs presenting at a veterinary teaching hospital, to identify the etiology and relative risk (RR) for SE in general and at the onset of seizures. Furthermore the outcome for dogs suffering from SE was to be evaluated.Animals: Three hundred and ninety-four dogs that were admitted to a veterinary teaching hospital (January 1, 2002 to March 31, 2008) with ES.Methods: All medical records of dogs with ES were identified by screening the clinical documentation system and evaluated for inclusion in this retrospective study.Results: Dogs with reactive seizures caused by poisoning had a significantly higher risk of developing SE (P o .001; RR 5 2.74), particularly as 1st manifestation of a seizure disorder (P 5 .001; RR 5 1.97). After SE, dogs with symptomatic epilepsy had a significantly lower probability of survival than dogs with idiopathic epilepsy (P o .001) and reactive ESs (P 5 .005).Conclusion and Clinical Importance: In dogs showing SE as the 1st manifestation of a seizure disorder, intoxication should always be considered and appropriate investigations undertaken. Dogs with SE owing to toxicosis have more favorable outcomes than dogs with symptomatic epilepsy (P o .001).

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Section: Discussionmentioning

confidence: 99%

Status Epilepticus and Epileptic Seizures in Dogs

Zimmermann¹,

Hülsmeyer²,

Sauter‐Louis

et al. 2009

Veterinary Internal Medicne

100

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“…Intact Belgian shepherd dogs with epilepsy have also been found to have an increased risk of being euthanased because of epilepsy compared to neutered dogs (Berendt and others 2008), which the authors attributed to a reduced seizure frequency in neutered dogs.…”

Section: Quantity Of Lifementioning

confidence: 99%

Epilepsy beyond seizures: a review of the impact of epilepsy and its comorbidities on health‐related quality of life in dogs

Packer

Volk

2015

Veterinary Record

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dog's quality of life (QoL) is of greatest importance to them above their seizure frequency; however, 5 much of the research into canine IE to date has focussed on seizure frequency, and how to reduce it 6 via anti-epileptic drug treatment. In humans, the impact of epilepsy upon QoL has been widely studied, 7 exploring its impact on physical health, but also the psychological health and cognitive capabilities of 8 affected individuals. This paper reviews the existing literature on canine IE, identifying potential 9 threats to QoL, drawing parallels from human epilepsy research. We suggest that canine IE poses 10 threats to both quality and quantity of life, with treatment interventions posing a fine balance of 11 potential benefits and harms to the patient. At present, little is known about the neurobehavioural, 12 emotional and cognitive effects of IE upon affected dogs, with further studies needed to establish the 13 extent to which unknown QoL-inhibiting comorbidities exist in the dog, to avoid their undertreatment. 14 More in-depth studies are required to objectively quantify the effects of IE on QoL

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“…An early study found the prevalence of epilepsy for BT in the United States to be 17% [3] which is higher than the estimated prevalence of 9.5 - 11.1% for BT and BS in Denmark [2]. In the general dog population, the prevalence of epilepsy is estimated to be approximately 1.0% [4].…”

Section: Introductionmentioning

confidence: 99%

“…Using the ILAE system, Berendt [2] completed a comprehensive survey of epilepsy in the Belgian shepherds of Denmark and reported the prevalence of epilepsy at 9.5% (49 out of 516 dogs). Of these 49 epileptic dogs, 71% of the dogs experienced either primary or secondarily generalized seizures.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs

et al. 2010

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BackgroundIdiopathic epilepsy in the Belgian shepherd dog is known to have a substantial genetic component. The objective of this study was to identify genomic regions associated with the expression of generalized seizures in the Belgian Tervuren and Sheepdog.ResultsDNA from 366 dogs, of which 74 were classified as epileptic, representing two extended families were subjected to a genome-wide linkage scan using 410 microsatellite markers yielding informative coverage averaging 5.95 ± 0.21 Mb. Though previous studies based on pedigree analyses proposed a major gene of influence, the present study demonstrated the trait to be highly polygenic. Studies of complex disorders in humans indicate that a liberal composite evaluation of genetic linkage is needed to identify underlying quantitative trait loci (QTLs). Four chromosomes yielded tentative linkage based upon LOD scores in excess of 1.0. Possible QTLs within these regions were supported also by analyses of multipoint linkage, allele frequency, TDT, and transmission of haplotype blocks.ConclusionsTaken together the data tentatively indicate six QTLs, three on CFA 2, and one on each of CFA 6, 12, and 37, that support fine mapping for mutations associated with epilepsy in the Belgian shepherd. The study also underscores the complexity of genomic linkage studies for polygenic disorders.

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Prevalence and characteristics of epilepsy in the Belgian shepherd variants Groenendael and Tervueren born in Denmark 1995–2004

Cited by 49 publications

References 28 publications

Status Epilepticus and Epileptic Seizures in Dogs

Status Epilepticus and Epileptic Seizures in Dogs

Epilepsy beyond seizures: a review of the impact of epilepsy and its comorbidities on health‐related quality of life in dogs

Genome-wide linkage scan for loci associated with epilepsy in Belgian shepherd dogs

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