Prevalence and characteristics of cervical human papillomavirus genotypes and cervical lesions among 58630 women from Guangzhou, China

Huiyun, Jiang; Ding, Jie; Wang, Huan; Yang, Yongtao; Li, Xiaomao

doi:10.1016/j.jiph.2023.07.013

Cited by 4 publications

(4 citation statements)

References 25 publications

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“…Therefore, our study serves to complement the existing literature by addressing this geographical gap and providing a more comprehensive perspective. Our retrospective analysis reveals that the overall prevalence of high-risk HPV infection in the western region of Guangzhou (18.46%) aligns with previous studies conducted in the eastern region ( 14 – 16 ). However, it is lower than the rates reported in Shenzhen (23.2%) ( 18 ), Taiwan (29.4%) ( 19 ), and certain areas of Hubei Province (44.4%) ( 20 ), while higher than those in Shanxi Province (14.8%) ( 21 ) and the Nyingchi City of Tibet (13.0%) ( 22 ).…”

Section: Discussionsupporting

confidence: 89%

“…Previous epidemiological investigations of high-risk HPV infection in Guangzhou have primarily focused on the eastern region, reporting infection rates of 14.07% ( 14 ), 13.94% ( 15 ), and 21.66% ( 16 ) respectively. Despite large sample sizes, these studies lack data from western Guangzhou and fail to delve into the relationship between multiple infections and cervical lesions.…”

Section: Introductionmentioning

confidence: 99%

“…The ATHENA study (12) confirmed the high sensitivity of HPV testing and its low rate of missed diagnoses for high-grade cervical intraepithelial neoplasia, making it a superior primary screening method compared to other screening methods. As a result, the U.S. FDA approved the Cobas HPV testing method as a primary screening method for cervical cancer in 2014 (13). However, some scholars have raised concerns, suggesting that HPV testing used solely as a primary screening method may detect a large number of individuals with transient HPV infections and potentially lead to missed diagnoses in HPV-negative cervical cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Current status of high-risk HPV infection and correlation with multiple infections in cervical lesions in Western Guangzhou

Li,

Lai,

Qin

et al. 2024

Front. Med.

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ObjectiveThis study aims to investigate the current status of multiple HPV infection and its association with cervical lesions in the western region of Guangzhou.MethodsA retrospective analysis of clinical data from cervical cancer screening patients was conducted. The patients were grouped based on HPV genotypes and cervical pathology results to explore the prevalence of high-risk HPV infection and its relationship with cervical lesions in the western region of Guangzhou. The study also analyzed the relationship between high-risk HPV infection and cervical lesions among different age groups.ResultsA total of 13,060 patients were included in the study, with an overall infection rate of 18.46% (2,411/13,060). Among them, the infection rate of HPV genotype 16 was 14.14% (341/2,411), HPV genotype 18 was 5.23% (126/2,411), and other 12 high-risk HPV genotypes accounted for 71.96% (1,735/2,411). When comparing the incidence of HSIL+ (high-grade squamous intraepithelial lesion or worse) among different HPV genotypes, the results showed that the HPV 16 infection group (47.50%) had a higher incidence than the HPV 18 infection group (25.40%) and the other 12 high-risk HPV genotypes group (15.97%; P < 0.05). In the multiple infection groups, the pathogenicity rates were 63.64% (7/11) for the 16+18 HPV infection group, 42.97% (55/128) for the 16+other 12 high-risk HPV genotypes infection group, 26.79% (15/56) for the 18+other 12 high-risk HPV genotypes infection group, and 57.14% (8/14) for the 16+18+other 12 high-risk HPV genotypes infection group. These rates were significantly different compared to the single infection group (P <0.01). Although there was no statistically significant difference in the incidence of cervical cancer between the HPV 16 infection group and the HPV 18 infection group, both groups had a higher incidence compared to the group with other 12 high-risk HPV genotypes infection (P < 0.05). Further analysis suggests that the severity of cervical lesions is not associated with the number of high-risk HPV infections, i.e., the severity of cervical lesions is unrelated to multiple HPV infections but is instead related to the pathogenicity of the HPV genotypes. The infection rate and multiple HPV infection rate of women under 35 years old were higher than those of women aged 35 and above (20% vs. 17.1%; 2% vs. 1.3%; P < 0.05). Moreover, the pathogenicity rate of HSIL+ among high-risk HPV infection increased with age.ConclusionsIn the western region of Guangzhou, the overall infection rate of high-risk HPV is 18.46%. The severity of cervical lesions is unrelated to multiple HPV infections. The fundamental reason is the distinct pathogenicity of different HPV genotypes. The HSIL+ pathogenicity rates, from high to low, are in sequence for HPV 16, HPV 18, and the other 12 HPV types.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Current status of high-risk HPV infection and correlation with multiple infections in cervical lesions in Western Guangzhou

Li,

Lai,

Qin

et al. 2024

Front. Med.

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“…HPV-16, HPV-52, HPV-51, HPV-58, and HPV-66 were the most common HR-HPV genotypes, similar with the main types of cervical region in Chinese females. 6 However, the rest were not HPV negative, due to only HR-HPV were tested and analyzed. HPV vaccines, including 2, 4, and 9 v, covered a part of the detected HR-HPV genotypes in our study.…”

mentioning

confidence: 99%

High‐risk human papillomavirus genotypes among healthy males from one hospital in Beijing, China

Du,

Ma,

Wang

et al. 2024

Journal of Medical Virology

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Human papillomavirus (HPV) infection causes a huge disease burden for both men and women with highly contagious through sexual contact. 1 Persistent high-risk HPV (HR-HPV) infection is known to lead to the development of cervical cancer, as well as the formation of tumors in the oropharyngeal, vagina, vulva, penis, anus, and head and neck, with a rapidly increasing incidence among young men. 2Previous studies have indicated that the global pooled prevalence of HPV in general men was 31% for any HPV and 21% for HR-HPV. 3 However, there is limited data available on healthy males in China. In this study, we aimed to describe the detection rate of HR-HPV among healthy males from a hospital in Beijing, China.The cross-sectional study was conducted from March 2013 to February 2023 at Beijing Chaoyang Hospital affiliated to Capital Medical University in China. A total of 357 healthy males who accepted for HR-HPV detection through physical examination were included in this study. The detailed experimental operation protocol was described in Supporting Information S1: File S1. The basic information and detection results were analyzed.Among 357 healthy males, 86 were infected with HR-HPV resulting in with a detection rate of 24.09% (95% confidence interval[CI]: 19.74%−28.87%) (Figure 1). The top five HR-HPV types with the highest detection rates were HPV-16 (5.60%), HPV-52 (4.76%), HPV-51 (4.48%), HPV-58 (3.36%), and HPV-66 (3.25%) (Figure 1A).

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Opportunities and challenges for human papillomavirus vaccination in China

Zhao,

et al. 2024

Human Vaccines & Immunotherapeutics

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Prevalence and characteristics of cervical human papillomavirus genotypes and cervical lesions among 58630 women from Guangzhou, China

Cited by 4 publications

References 25 publications

Current status of high-risk HPV infection and correlation with multiple infections in cervical lesions in Western Guangzhou

Current status of high-risk HPV infection and correlation with multiple infections in cervical lesions in Western Guangzhou

High‐risk human papillomavirus genotypes among healthy males from one hospital in Beijing, China

Opportunities and challenges for human papillomavirus vaccination in China

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