Prevalence and Characteristics of Autism Spectrum Disorder Among Spanish School-Age Children

Morales-Hidalgo, Paula; Roigé-Castellví, Joana; Hernández‐Martínez, Carmen; Voltas, Núria; Canals, Josefa

doi:10.1007/s10803-018-3581-2

Cited by 83 publications

(65 citation statements)

References 61 publications

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“…Estimates report a prevalence of ASD of between 0.6% and 1.7% in children and adolescents, representing a serious public health problem. It has also been observed that males are up to 4 times more likely than females to be diagnosed with ASD [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

et al. 2020

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Background: Autism spectrum disorder (ASD) is a public health problem and has a prevalence of 0.6%–1.7% in children. As well as psychiatric symptoms, dysbiosis and gastrointestinal comorbidities are also frequently reported. The gut–brain microbiota axis suggests that there is a form of communication between microbiota and the brain underlying some neurological disabilities. The aim of this study is to describe and compare the composition of gut microbiota in children with and without ASD. Methods: Electronic databases were searched as far as February 2020. Meta-analyses were performed using RevMan5.3 to estimate the overall relative abundance of gut bacteria belonging to 8 phyla and 17 genera in children with ASD and controls. Results: We included 18 studies assessing a total of 493 ASD children and 404 controls. The microbiota was mainly composed of the phyla Bacteroidetes, Firmicutes, and Actinobacteria, all of which were more abundant in the ASD children than in the controls. Children with ASD showed a significantly higher abundance of the genera Bacteroides, Parabacteroides, Clostridium, Faecalibacterium, and Phascolarctobacterium and a lower percentage of Coprococcus and Bifidobacterium. Discussion: This meta-analysis suggests that there is a dysbiosis in ASD children which may influence the development and severity of ASD symptomatology. Further studies are required in order to obtain stronger evidence of the effectiveness of pre- or probiotics in reducing autistic behaviors.

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Section: Introductionmentioning

confidence: 99%

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

et al. 2020

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“…Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social communication and rigid repetitive patterns of behaviors or interests [American Psychiatric Association, 2013;Saqr, Braun, Porter, Barnette, & Hanks, 2018]. In recent decades, the worldwide prevalence of ASD has risen to 0.7-1.5% in childhood and adolescence [Morales-Hidalgo, Roige-Castellvi, Hernandez-Martinez, Voltas, & Canals, 2018], attracting the attention of researchers. Several resting-state functional magnetic resonance imaging (rsfMRI) studies of ASD have been published, especially with the emergence of data-sharing initiatives such as the Autism Brain Imaging Data Exchange (ABIDE) [Di Martino et al, 2017;Di Martino et al, 2014].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Functional Connectivity Reveals Abnormal Variability and Hyper‐connected Pattern in Autism Spectrum Disorder

Zhu

Nguchu

et al. 2019

Autism Research

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Autism spectrum disorder (ASD) is a general neurodevelopmental disorder associated with altered brain connectivity. However, most connectivity analyses in ASD focus on static functional connectivity, largely neglecting brain activity dynamics that have been reported to provide deeper insight into the underlying mechanisms of brain functions. Therefore, we anticipate that the use of dynamic functional connectivity (DFC) with interaction of clustering measures could help characterize ASD severity and reveal more information. In this study, we applied the sliding‐window and k‐means clustering methods to perform DFC and clustering analyses in ASD and typically developing (TD) groups. Data from 62 ASD and 63 TD children were acquired from the open‐access data set Autism Brain Imaging Data Exchange. Our findings revealed higher DFC variability between the posterior cingulate gyrus (PCC) and middle temporal pole (TPOmid) in subjects with ASD. The connection between the PCC and pars opercularis of inferior frontal gyrus (IFGoper) also presented greater variability in ASD, with the increase depending on ASD symptom severity. Furthermore, clustering analysis showed higher averaged dwell time and probability of transition for globally hyper‐connected state in the ASD group, which could be related to connection variability between the PCC and IFGoper. Our results demonstrate that both the PCC and IFGoper play crucial roles in characterizing symptom severity and state configuration in ASD, and brain connectivity dynamics may serve as potential indicators of ASD in future studies. Autism Res 2020, 13: 230–243. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Dynamic functional connectivity (DFC) refers to functional connectivity that changes over a short time. This study found that DFC instability between the posterior cingulate gyrus and pars opercularis of inferior frontal gyrus is associated with abnormal brain pattern configurations and dysfunction of social cognitive processes in autism spectrum disorder (ASD). These findings could contribute to a deeper understanding of the neural mechanisms of ASD and help characterize ASD severity.

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“…Given the increased awareness of the importance of early diagnosis and intervention for children with autism spectrum disorders (ASD), gold standard diagnostic measures, such as the Autism Diagnostic Observation Schedule [Lord et al, ] and Autism Diagnostic Observation Schedule‐2 (ADOS‐2 [Lord et al, ]), have become more accessible internationally for young children with ASD [Baird et al, ; Baron‐Cohen et al, ; Boilson, Staines, Ramirez, Posada, & Sweeney, ; Fombonne et al, ; Kim et al, ; Morales‐Hidalgo, Roigé‐Castellví, Hernández‐Martínez, Voltas, & Canals, ; Rudra et al, ; Sun, Allison, Matthews, et al, ]. The increased use of the ADOS‐G/ADOS‐2 in international studies has also been driven by the translation of the ADOS‐G/ADOS‐2 into more than 12 languages; however, studies examining the diagnostic validity of the measure have been mainly conducted in Western countries including the United States [Gotham, Risi, Pickles, & Lord, ], Canada [Risi et al, ], United Kingdom [Le Couteur, Haden, Hammal, & McConachie, ], the Netherlands [de Bildt et al, ], Germany [Bölte & Poustka, ], Poland [Chojnicka & Pisula, ], Greece [Papanikolaou et al, 2009], and Sweden [Zander, Sturm, & Bölte, ].…”

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confidence: 99%

Exploring diagnostic validity of the autism diagnostic observation schedule‐2 in South Korean toddlers and preschoolers

et al. 2019

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This study aims to provide the initial validity of the Autism Diagnostic Observation Schedule-2 (ADOS-2) Toddler Module and Module 1-2 for South Korean toddlers and preschoolers. Based on 143 children, the ASD group (n = 68) showed significantly higher ADOS-2 item and algorithm total scores as well as social affect and repetitive and restricted behaviors domain scores compared with children with nonspectrum (NS; n = 42) disorders and typically developing (TD; n = 33) children. Using lower algorithm cutoffs, sensitivities were excellent for the ASD versus NS/TD comparisons, ranging from 94% to 100% across different Modules. Specificities varied more, ranging from 82% to 100%. Internal consistency was strong with high item-total correlations (r of 0.6-0.9) and Cronbach's Alphas (all above 0.7). Results demonstrated promising, initial evidence for the validity of the ADOS-2 for South Korean toddlers and preschoolers from 1 to 4 years of age. The ADOS-2 could be implemented, with minimal adaptations, in research and clinical settings in South Korea. This study is one of the first steps toward validating the ADOS-2 in other Eastern countries that are in great need for a valid instrument for the detection of ASD.Lay Summary: Results of this study demonstrated promising, initial evidence for the validity of a gold standard measure for the diagnosis of autism, the Autism Diagnostic Observation Schedule-2 (ADOS-2), for South Korean toddlers and preschoolers. The ADOS-2 could be implemented, with minimal adaptations, in research and clinical settings in South Korea. This study is one of the first steps toward validating the ADOS-2 in other Eastern countries that are in great need of a valid instrument for the detection of ASD.

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Prevalence and Characteristics of Autism Spectrum Disorder Among Spanish School-Age Children

Cited by 83 publications

References 61 publications

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Composition of Gut Microbiota in Children with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis

Dynamic Functional Connectivity Reveals Abnormal Variability and Hyper‐connected Pattern in Autism Spectrum Disorder

Exploring diagnostic validity of the autism diagnostic observation schedule‐2 in South Korean toddlers and preschoolers

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