Prevalence and burden of headache disorders in two neighboring provinces of China

Luo, Ning; Qi, Weiwei; Tong, Wangxia; Tan, Feng; Zhang, Qian; He, Junyi; Zou, Daliang; Cao, Xiutang; Xu, Xuehua; Bai, Hua; Ou, Jiangang; Wu, Huihui; Chen, Zilong; Zhou, Yane; Wan, Sai-ying; Yan, Hong; Wang, Jingliang; Ding, Minghui; Zhang, Aiwu; Zhu, Daoyuan; Yu, Fang

doi:10.1016/j.jocn.2014.01.023

Cited by 6 publications

(6 citation statements)

References 14 publications

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“…Some epidemiological studies have shown that several risk factors, including sex [7], body mass index (BMI) [8], smoking [9], family history [10], and climate [11] might be associated with primary headache disorders. Despite the lower prevalence in China, the risk factors are similar to those reported for other countries [12][13][14]. In a previous study in North China, we found that the prevalence of primary headache disorders in nurses was significantly higher than that in the general population (45.3% vs. 23.8%) [15].…”

Section: Introductionsupporting

confidence: 84%

Prevalence and risk factors associated with headache amongst medical staff in South China

Xie

et al. 2020

J Headache Pain

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Background: A previous study by our team reported the prevalence of primary headache disorders and factors associated with headache among nurses in three hospitals in North China. The aim of this cross-sectional survey was to learn more about how medical nurses in South China were affected by headache. Additionally, we determined the prevalence of headache and measured the impact of headache among doctors in mainland China for the first time. Methods: Stratified random cluster sampling was used to select 280 physicians and 365 nurses from various departments in four hospitals in Sanya, which is one of southernmost cities in China. Information was collected on demographic data, occupational factors and headache characteristics by using a structured questionnaire. Results: Among 645 medical staff, 548 (85%) responded (doctors = 240, nurses = 308). Among the medical staff, the 1year prevalence of primary headache disorders was 50%, with 25.9% experiencing migraine and 24.1% experiencing tension-type headache (TTH). The prevalence of migraine in female doctors was higher than that in female nurses, although this difference was not significant (32.4% vs. 29.8%, P = 0.628). Multivariate analysis showed that being female and working in other specialties (Emergency Department & Radiology Department) remained independent risk factors for migraine in doctors (OR 2.314 and 3.223). In nurses, being married was a risk factor for migraine (OR 3.728), and job titles remained an independent risk factor for migraine and TTH (OR 2.294 and 4.695). Working more than 6 night-shifts per month was associated with an increased prevalence of migraine and TTH in doctors; the same was true in nurses for migraine, but not for TTH. Conclusion: The prevalence of primary headache disorders in both nurses and doctors is higher than that in the general population in South China. Our study shows that occupation, geography and sex may play an important role. Further, female doctors are more susceptible than female nurses to migraine. The risk factors relevant to headache that were found in this study should provide an important reference for promoting occupational health in medical staff, especially female doctors in China.

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Section: Introductionsupporting

confidence: 84%

Prevalence and risk factors associated with headache amongst medical staff in South China

Xie

et al. 2020

J Headache Pain

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“…In China, population-based estimates of the 1-year prevalence of migraine range from 7.9% to 14.3% in adults [4][5][6]. Health-related quality-of-life studies in China, including Taiwan, have demonstrated substantial negative effects of migraine on physical and emotional functioning, impacting work, household, and leisure activities [5,[7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database

Zhang

Yao

et al. 2020

J Headache Pain

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Background: Adult migraine remains underdiagnosed and undertreated, despite significant negative effects on physical and emotional functioning. Information on prescribing patterns and treatment costs of migraine in China is limited. Methods: This retrospective analysis of the China Health Insurance Research Association (CHIRA) medical insurance claims database in 2016 to 2017 evaluated treatment patterns, direct medical costs, and healthcare resource utilization among adults with migraine in mainland China. Results: Of 108,375 patients with headache-related outpatient visits, 10,652 were adults with migraine (mean age 51.4 years, 55.4% female). Common comorbidities were major depressive disorder (4.1%), insomnia (3.8%), and anxiety (2.3%). Migraine patients were prescribed acute medication (26.4%), preventive medication (15.0%), and Chinese patent and herbal medicines (24.5% and 11.7%, respectively). Of patients prescribed acute medication, 68.8% received non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), 7.1% received opioids, while only 3.3% received triptans. Mean annual outpatient costs per patient were 46.5 United States dollars (USD), with mean (standard deviation) 1.8 (2.0) outpatient visits per year. Medication costs for traditional Chinese medicine (22.4 USD per patient) were higher than for Western medicine (13.5 USD). Conclusion: Among migraine patients in China, NSAIDs were commonly prescribed as acute medication, while utilization of migraine-specific triptans and preventive medications was low.

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“…Migraine is a common episodic neurological disorder which is mainly characterized by recurrent attacks of headache, which has a great detrimental in uence on quality of life (1,2). The annual prevalence of migraine estimated in the worldwide population were around 9% and migraine predominantly affects females (3)(4)(5)(6), resulting in an increasing nancial burden on global economies (7,8). Given such a situation, considerable empirical efforts have been devoted into understanding the causes of migraine because it would help with identifying risk factors, establishing correct diagnosis and developing a range of effective therapeutic interventions (9).…”

Section: Introductionmentioning

confidence: 99%

Response inhibition alterations in migraine: An event-related potential study

Chen¹,

Y²,

Zhao³

et al. 2020

Preprint

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Background Migraine is characterized by a hypersensitivity to environmental stimulation which climaxes during headache attacks but persists during attack-free period. Despite ongoing debates about the nature of the mechanisms giving rise to this abnormality, the presence of deficient inhibitory cortical processes has been proposed to be one possible mechanism underlying its pathogenesis. Empirical evidence supporting this notion is mainly based on previous findings showing functional cortical hyperexcitability in the sensory domain. Considering that a general inhibitory control process can play an important role across early to later stage of information processing, this may in turn indicate the important role other dimensions of inhibitory control can play in migraine disability. To this end, the present study was designed to examine the pathophysiological basis of inhibitiory control that takes place during suppression of prepotent responses. Methods Twenty-two patients with migraine without aura (mean age = 30.86 ± 5.69 years; 19 females) during the interictal period and 25 healthy controls (mean age = 30.24 ± 3.52 years; 18 females) were recruited. We employed a stop signal task in combination with event-related potentials (ERPs) to examine participants’ neural activity supporting response inhibition. Results Behaviorally, migraineurs exhibited prolonged reaction times to the stop signal relative to healthy controls. At the neural level, the amplitude of the stop-N2, a component of the ERPs related to conflict monitoring during early, non-motoric stages of inhibition, was significantly increased in migraineurs. Meanwhile, the amplitude of the stop-P3, a component of the ERPs reflecting late-stage inhibition of the motor system itself and cognitive evaluation of motor inhibition, was also significantly increased in migraineurs. Moreover, our time-frequency analysis has further revealed increased delta activity in the time window used to extract the mean amplitude of the stop-P3 in migraineurs relative to healthy controls. Conclusions Consistent with the theory that cortical hyperexcitability is a key signature of migraine, these findings revealed a decrease in suppressing prepotent responses in migraineurs, which can be attributable to cortical hyperexcitability. These novel findings imply the existence of dysfunctional inhibitory control at later stage of information processing.

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Prevalence and burden of headache disorders in two neighboring provinces of China

Cited by 6 publications

References 14 publications

Prevalence and risk factors associated with headache amongst medical staff in South China

Prevalence and risk factors associated with headache amongst medical staff in South China

Migraine treatment and healthcare costs: retrospective analysis of the China Health Insurance Research Association (CHIRA) database

Response inhibition alterations in migraine: An event-related potential study

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