Prevalence and breed distribution of chronic pancreatitis at post‐mortem examination in first‐opinion dogs

Watson, Penny; Roulois, Aude; Scase, T.; Johnston, Pamela; Thompson, H.; Herrtage, M. E.

doi:10.1111/j.1748-5827.2007.00448.x

Cited by 88 publications

(133 citation statements)

References 33 publications

(64 reference statements)

Supporting

Mentioning

118

Contrasting

Unclassified

Order By: Relevance

“…The types of lesions that were present were similar to those known to be present in dogs randomly presented for postmortem. 5,11 Nodular hyperplasia was found in fewer samples than has been previously reported, 6 and this finding is likely because of the young age of the dogs in the present study. The extent of necrosis, hemorrhage, and fibrin present in the necropsy samples adjacent to the biopsy sites was striking and likely represents an acute change induced by biopsy sampling that has not been previously documented.…”

Section: Discussioncontrasting

confidence: 54%

Effect of Pancreatic Tissue Sampling on Serum Pancreatic Enzyme Levels in Clinically Healthy Dogs

et al. 2010

View full text Add to dashboard Cite

Abstract. Little is known about the potential consequences of pancreatic tissue sampling in dogs. The goal of the present study was to evaluate changes in serum trypsin-like immunoreactivity and canine-specific pancreatic lipase after pancreatic fine-needle aspiration and surgical biopsy in 27 clinically healthy dogs. Presurgical, ultrasound-guided aspiration of the pancreas was performed with the dogs under sedation. Subsequently, all the dogs underwent intraoperative pancreatic fine-needle aspiration and clamshell biopsy. After euthanasia, pancreata were sectioned for histopathologic evaluation. Serum pancreatic enzyme levels were measured at 3 time points: baseline, after ultrasound-guided aspiration, and after intraoperative aspiration and biopsy. No significant differences were detected among mean serum pancreatic lipase values at any point (P . 0.05). Serum trypsin-like immunoreactivity did not change from baseline (18.2 6 2.1 mg/dl; mean 6 standard error) after ultrasound-guided aspiration (13.6 6 2.2 mg/dl) but increased significantly after intraoperative sampling (44.8 6 1.9 mg/dl; P , 0.0005). After surgical biopsy, the 20 dogs that had both ultrasound-guided and intraoperative sampling had a higher mean (SE) serum trypsin-like immunoreactivity (44.8 6 1.9 mg/dl) than the 7 dogs that had only intraoperative samples taken (36.4 6 4.1 mg/dl; P , 0.05). All 27 pancreata were grossly normal before intraoperative sampling. Pancreatic sampling was associated with increased serum trypsin-like immunoreactivity and mild, peracute necrosis, inflammation, hemorrhage, and fibrin deposition. Tissue damage from sampling was not sufficient to cause an elevation in canine-specific pancreatic lipase in the time frame evaluated. Further studies are needed to determine longer-term effects of pancreatic sampling on enzyme levels and clinical outcome.

show abstract

Section: Discussioncontrasting

confidence: 54%

Effect of Pancreatic Tissue Sampling on Serum Pancreatic Enzyme Levels in Clinically Healthy Dogs

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The presence of active pancreatic disease (as indicated by pancreatic and peripancreatic fat necrosis) in the clinical chronic pancreatitis dogs likely accounts for the higher prevalence of clinical signs in this group of dogs compared to that of the incidental chronic pancreatitis group. This might provide a plausible explanation for the discrepancy of the prevalence of chronic pancreatitis between necropsy studies and clinical impressions (Newman et al, 2006;Watson et al, 2007;Xenoulis et al, 2008;Watson et al, 2010a). Chronic pancreatitis cases that are not associated with pancreatic and peripancreatic fat necrosis are less likely to develop clinical signs, and therefore, they might escape clinical diagnosis more easily.…”

Section: Discussionmentioning

confidence: 99%

“…In those studies, histopathologic findings suggestive of chronic pancreatitis were present in an unexpectedly large number of dogs, ranging between 34% and 64% of all cases examined (Newman et al, 2004;Watson et al, 2007). However, these studies do not provide any information on how these histopahological findings translate into clinical disease; therefore, the clinical importance of those findings remains unknown.…”

Section: Introductionmentioning

confidence: 94%

“…Recent published information on canine chronic pancreatitis is almost exclusively based on histopathology studies (Newman et al, 2004;Watson et al, 2007). In those studies, histopathologic findings suggestive of chronic pancreatitis were present in an unexpectedly large number of dogs, ranging between 34% and 64% of all cases examined (Newman et al, 2004;Watson et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chronic pancreatitis in dogs: A retrospective study of clinical, clinicopathological, and histopathological findings in 61 cases

Bostrom

Xenoulis

Newman

et al. 2013

The Veterinary Journal

View full text Add to dashboard Cite

The objective of the present study was to characterize the clinical, clinicopathologic, and histopathologic findings of dogs with chronic pancreatitis. The necropsy database at Texas A&M University was searched for reports of dogs with histologic evidence of chronic pancreatitis defined as irreversible histologic changes of the pancreas, i.e. fibrosis and atrophy. Medical records and necropsy reports were retrieved and reviewed. A reference necropsy population of 100 randomly selected dogs was used for signalment and concurrent disease comparisons. Cases were categorized as clinical or incidental chronic pancreatitis based on the presence of vomiting, decreased appetite, or both versus neither of these signs. All archived pancreata samples were evaluated histologically and scored using a published pancreatic scoring system. A total of 61 dogs with chronic pancreatitis were included in the study. The most frequent clinical signs were lethargy, decreased appetite, vomiting, and diarrhea. Compared to the reference necropsy population, chronic pancreatitis cases were more likely to be older, neutered, and of the non-sporting/toy breed group and to have concurrent endocrine, hepatobiliary, or neurologic diseases. Clinical chronic pancreatitis cases had significantly higher histological scores for pancreatic necrosis and peripancreatic fat necrosis. Clinical chronic pancreatitis cases were significantly more likely to have hepatobiliary or endocrine disease as well as increased liver enzyme activities, and cholesterol and bilirubin concentrations. In conclusion, clinical disease resulting from chronic pancreatitis might be related to the presence of pancreatic necrosis and pancreatic fat necrosis. The signalment, presentation, and concurrent diseases of dogs with chronic pancreatitis are similar to those previously reported for dogs with acute pancreatitis.

show abstract

“…However, in dogs the pathogenetic association between these two conditions is less clear (Xenoulis et al 2008). An association between IBD and CP has not been reported in canines yet, but CP may have been under-recognized in dogs with studies suggesting that it may be more frequent than previously thought (Newman et al 2006;Watson et al 2007). However, it has been suggested that some dogs with IBD have elevated pancreatic lipase immunoreactivity (cPLI) and that this may be suggestive of IBD-associated pancreatitis (Kathrani et al 2009).…”

mentioning

confidence: 91%

Protein-losing enteropathy in a dog with lymphangiectasia, lymphoplasmacytic enteritis and pancreatic exocrine insufficiency

Rodríguez-Alarcón

Pérez-Casio

Rivera

et al. 2012

Veterinary Quarterly

View full text Add to dashboard Cite

Prevalence and breed distribution of chronic pancreatitis at post‐mortem examination in first‐opinion dogs

Cited by 88 publications

References 33 publications

Effect of Pancreatic Tissue Sampling on Serum Pancreatic Enzyme Levels in Clinically Healthy Dogs

Effect of Pancreatic Tissue Sampling on Serum Pancreatic Enzyme Levels in Clinically Healthy Dogs

Chronic pancreatitis in dogs: A retrospective study of clinical, clinicopathological, and histopathological findings in 61 cases

Protein-losing enteropathy in a dog with lymphangiectasia, lymphoplasmacytic enteritis and pancreatic exocrine insufficiency

Contact Info

Product

Resources

About