Prevalence and Associations of the Use of Proton-Pump Inhibitors in Nursing Homes: A Cross-Sectional Study

Barreto, Philipe de Souto; Lapeyre‐Mestre, Maryse; Mathieu, Céline; Piau, Christine; Bouget, Catherine; Cayla, Françoise; Vellas, Bruno; Rolland, Yves

doi:10.1016/j.jamda.2012.10.018

Cited by 47 publications

(40 citation statements)

References 30 publications

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“…Twelve of them were excluded since they did not report the outcome of interest while six articles were excluded since they were descriptive studies without comparators. Four articles (two cohort studies, one case-control study, and one cross-sectional study) met the eligibility criteria and were included in the data analysis (8,9,16,17). Figure 1 outlines the literature review and study selection process.…”

Section: Resultsmentioning

confidence: 99%

Proton pump inhibitors and risk of dementia

Wijarnpreecha¹,

Thongprayoon²,

Panjawatanan³

et al. 2016

Ann. Transl. Med.

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Background: Proton pump inhibitors (PPIs) are one of the most commonly prescribed medications. Recent studies have raised a concern over increased risk of dementia among PPIs users but the results of those studies were inconsistent. We conducted this systematic review and meta-analysis to summarize all available data.Methods: A literature search was performed in MEDLINE and EMBASE database from inception to April 2016.Observational studies that reported risk of dementia among PPIs users compared with non-users were included.Point estimates were extracted from individual studies and pooled risk ratios (RR) with 95% confidence intervals (CI) were calculated using a random-effect, generic inverse variance method.Results: Four studies were included in the analysis. Pooled RR of dementia among PPIs users compared with non-users was 1.08 (95% CI, 0.82-1.43). Sensitivity analysis including only cohort studies demonstrated a higher risk with pooled RR of 1.44 (95% CI, 1.36-1.52). Conclusions:Our study demonstrated an increased risk of dementia among PPIs users. Whether this association is causal requires further investigations.

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Section: Resultsmentioning

confidence: 99%

Proton pump inhibitors and risk of dementia

Wijarnpreecha¹,

Thongprayoon²,

Panjawatanan³

et al. 2016

Ann. Transl. Med.

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“…Proton pump inhibitors (PPI) constitute a very effective and used treatment at present [1][2][3]. Previously, they would seem to cause undesirable effects and medicinal interactions probably serious and badly known, especially for the elderly person often fragile and exposed to a polypharmacy [4].…”

Section: Introductionmentioning

confidence: 99%

“…Previously, they would seem to cause undesirable effects and medicinal interactions probably serious and badly known, especially for the elderly person often fragile and exposed to a polypharmacy [4]. On the other hand, it is a very expensive therapeutic class and frequently used in an inappropriate way [2][3][4]. In Tunisia, the use of these medicines to the old subject, in the public structures, by specialists, was not studied.…”

Section: Introductionmentioning

confidence: 99%

Prescription of Proton Pump Inhibitors in Elderly Subjects in Real Life: A Retrospective Study in a Gastroenterology Department

Boudabous¹,

Gdoura²,

Mnif³

et al. 2017

Esophageal Abnormalities

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The proton-pump inhibitor (PPI) is an effective and widely used treatment but may cause side effects, especially for the elderly. Materials and methods: this is a cross-sectional study including 45 patients older than 65 years, followed at our outpatient and treated with PPIs for at least a year. The indication for PPI, the results of any endoscopy, and the quality of the tolerance of these molecules is specified by the data folder. During the consultation, we conducted an interrogation to an update of the history and medications to our patients and a type checking of the molecule, the dose, and the quality of the observance. Results: patients were divided into 32 women and 13 men with a mean age of 75 ± 7 years (65-92). The average length of PPI use was 6 ± 4 years (1-16) with a consumption of a double dose for at least 1 year in 28.8% of cases. The prescribed dose was higher than the recommended dose in at least 15.5% of cases. PPIs were well tolerated. One patient had presented a microscopic colitis, revealed by diarrhea regressed after discontinuation of PPIs. Conclusion: PPIs were prescribed in elderly subjects by gastroenterologists, in a university center, with a high dose and long. In our series, this treatment is well tolerated in the elderly.

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“…The use of selective serotonin reuptake inhibitors (SSRIs), can lead to hyponatremia and delirium (54). Proton pump inhibitors (PPIs) are overused in older persons, leading to reduced vitamin B12 and calcium absorption and possibly bacterial overgrowth and clostridium difficile infections (55). In geriatric wards and nursing homes PPIs are associated with increased mortality (56).…”

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confidence: 99%