Prevalence and association between herpes simplex virus types 1 and 2-specific antibodies in attendees at a sexually transmitted disease clinic

Roest, R. Wim; Meijden, WI van der; Dijk, Grietje van; Groen, Jan; Mulder, P.G.H.; Verjans, Georges M. G. M.; Osterhaus, A.D.M.E.

doi:10.1093/ije/30.3.580

Cited by 29 publications

(22 citation statements)

References 27 publications

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“…Recently, HSV-1 seropositivity was associated with the female sex (9,31). This finding agrees with studies showingthat HSV-1-specific antibodies are generally more abundant in female mice than in male mice-a difference that disappears upon castration (22).…”

Section: Discussionsupporting

confidence: 86%

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

Ramı́rez

Sastre

Alfaro

et al. 2005

J Virol

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Herpes simplex virus type 1 (HSV-1) causes disease in humans and animals. Infection usually occurs via the neural route and possibly occurs via the hematogenous route. The latter, however, is the main route by which immunosuppressed individuals and neonates are infected. Gender-dependent differences in the incidence and severity of some viral infections have been reported. To detect differences between the sexes with respect to HSV-1 colonization and disease, the characteristics of both acute and latent infections in hematogenously infected male and female mice were compared. In acute infection, the female mice had a poorer outcome: HSV-1 colonization was more effective, especially in the gonads and brain. In the encephalon, the midbrain had the highest viral load. In latent infection, brain viral loads were not significantly different with respect to sex. Significant differences were seen, however, in the blood and trigeminal ganglia: HSV-1 seroprevalence was observed in females, with no virus detected in males. In brain dissections, only the cerebral cortex of the females had viral loads statistically higher than those observed in the males. The spread of the virus to several organs of interest during acute infection was examined immunohistochemically. Female mice showed greater viral immunostaining, especially in the adrenal cortex, gonads, and midbrain. In male mice, HSV-1 was detected predominantly in the adrenal cortex. It was also found that apolipoprotein E promotes virus colonization of the ovaries, the APOE gene dose being directly related to viral invasiveness.

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Section: Discussionsupporting

confidence: 86%

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

Ramı́rez

Sastre

Alfaro

et al. 2005

J Virol

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“…High HSV-2 seroprevalences have been well documented among MSM groups in developed countries [4], with rates as high as 26%-66% in several US cities [5,6], 33%-58% in Amsterdam [7,8], 15% in Rotterdam [9], 51%-86% in Rome [10], and 11%-61% in London [11]. HSV-2 seroprevalence data from developing countries have been generated primarily from African and Asian countries [12] and have focused on non-MSM risk groups, such as female sex workers, bar workers, and STI clinic attendees [13].…”

mentioning

confidence: 99%

Association of Herpes Simplex Virus Type 2 Infection and Syphilis with Human Immunodeficiency Virus Infection among Men Who Have Sex with Men in Peru

et al. 2006

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“…There are conflicting results from studies on the risk of HSV-1 positive patients of acquiring HSV-2 that are reported that previous HSV-1 infection does not reduce susceptibility to subsequent genital HSV-2. 28 Furthermore, our results indicate statistically significant a higher prevalence of HSV-2 IgG in HIV-positive patients when compared to 5% HIV-negative patients. This finding is consistent with most previous studies in other countries.…”

Section: Discussionmentioning

confidence: 48%

Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients

Sufiawati

Widyaputra

Djajakusumah

2012

Dent. J. (Majalah Kedokteran Gigi)

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Background: Herpes simplex virus (HSV) is a common cause of viral opportunistic infections among HIV t-tests and analysis of variance (ANOVA). Results: There were no significant differences in HSV-1 seroprevalence between HIV-positive patients (71%) and HIV-negative patients (66%). HSV-2 seroprevalence was significantly higher in HIV-positive patients (30%) than HIV-negative patients (5%). The titers of HSV-1 IgG antibodies in HIV-positive patients (mean 24.63 ± 19.06 IDU) were significantly lower than those of HIV-negative patients (mean 44.62 ± 33.22 IDU). In contrast, HSV-2 IgG antibody titers in HIV-positive patients (mean 13.31 ± 20.28 IDU) were significantly higher than HIV-negative patients (mean 4.42 ± 10.99 IDU)

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Prevalence and association between herpes simplex virus types 1 and 2-specific antibodies in attendees at a sexually transmitted disease clinic

Cited by 29 publications

References 27 publications

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender

Association of Herpes Simplex Virus Type 2 Infection and Syphilis with Human Immunodeficiency Virus Infection among Men Who Have Sex with Men in Peru

Seroprevalence of Herpes Simplex virus types 1 and 2 and their association with CD4 count among HIV-positive patients

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