Prevalence and associated risk factors of Neospora caninum infection among cattle in mainland China: A systematic review and meta-analysis

Zhu, Ying; Zhu, Zifu; Xu, Yang; Liu, Jing; Liu, Qun

doi:10.1016/j.prevetmed.2022.105593

Cited by 7 publications

(8 citation statements)

References 46 publications

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“…In Southern Vietnam, the N. caninum seroprevalence varied between 16 and 53% in the state herds, and the prevalence of N. caninum was higher in the herds that had imported cows than in the herds that only had locally bred cows ( 27 ). In China, the average seroprevalence of N. caninum was 13.69% in cattle herds, and the presence or absence of pregnancy and the number of pregnancies is considered as risk factors ( 16 ). In the present survey, the average seroprevalence of N. caninum in cattle herds in Shanxi was 13.60% detected by ELISA, which was similar to the average seroprevalence in China.…”

Section: Discussionmentioning

confidence: 99%

“…The geographical location was revealed as a risk factor for N. caninum infection in cattle in Shanxi Province ( P < 0.001; Table 2 ). Studies have shown that sex, age, whether or not the cattle are pregnant, and the management mode of the farm are potential risk factors for N. caninum seroprevalence in cattle ( 16 , 33 ). Unfortunately, the collection of cattle serum samples in the present study was done by blind sampling, thus data about the sex and age of the sampled cattle, and whether or not the cattle sampled was pregnant, were not available; so we explored whether management mode was a risk factor for N. caninum infection in cattle in Shanxi Province.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, neosporosis in cattle has also been widely reported in China. A recent review showed that the average seroprevalence of N. caninum was 13.69% in cattle herds in China, and the prevalence of N. caninum infection in cattle has been reported in many provinces of China ( 16 ). But so far, information on N. caninum infection in cattle in Shanxi Province is very limited, only two articles mentioned that the seroprevalence of N. caninum in cattle in Shanxi Province was 23.08% (6/26).…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Neospora caninum infection and associated risk factors in cattle in Shanxi Province, north China

et al. 2022

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Neospora caninum is an obligate intracellular parasitic protozoan that can cause abortions in cattle and pose considerable economic losses to the cattle industry. As a major livestock province, little is known of N. caninum infection in cattle in Shanxi Province, north China. In order to investigate the seroprevalence of N. caninum in cattle in Shanxi Province, 978 cattle serum samples were collected from 11 cities in three representative geographical locations in Shanxi Province, and the N. caninum-specific IgG antibodies were examined using an indirect enzyme linked immunosorbent assay (ELISA) kit commercially available. The results showed that 133 of the 978 examined cattle serum samples (13.60%, 95% CI = 11.45–15.75) were positive for N. caninum antibodies, and the seroprevalence in different cities ranged from 0 to 78.89%. The geographical location and management mode were the risk factors associated with N. caninum infection in cattle herds in Shanxi Province. Cattle in Northern and Central Shanxi Province as well as cattle whose management mode is that of large-scale cattle farming companies are more susceptible to N. caninum infection. This was the first large-scale survey of N. caninum seroprevalence and assessment of associated risk factors in cattle in Shanxi Province, which provided baseline information for the prevention and control of N. caninum infection in cattle in Shanxi Province, north China.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of Neospora caninum infection and associated risk factors in cattle in Shanxi Province, north China

et al. 2022

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“…Various studies have suggested that rodents may play a role in the maintenance of the N. caninum life cycle and the dissemination of N. caninum in the environment (Benavides et al, 2022;Ferroglio et al, 2003Ferroglio et al, , 2005Hamidinejat et al, 2011). Although a high prevalence of N. caninum has been reported in a number of herbivores and carnivores (Anvari et al, 2020;Ying et al, 2022), limited data are available on the exposure of rodent to N. caninum.…”

Section: Introductionmentioning

confidence: 99%

Global prevalence of Neospora caninum in rodents: A systematic review and meta‐analysis

Hamzavi

Salimi

Ahmadi

et al. 2023

Veterinary Medicine & Sci

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BackgroundNeosporosis has been considered a cause of abortion in dairy and beef cattle worldwide. Rodents are reservoir hosts for several infectious diseases. It is necessary to determine the prevalence of Neospora caninum in rodents to improve the current understanding of the transmission dynamics of Neospora as well as its life cycle and risk of transmission to livestock. Therefore, the objective of the present study was to estimate the pooled global prevalence of N. caninum in different rodent species.MethodsPublished studies on the prevalence of N. caninum in different rodent species were searched in the MEDLINE/PubMed, ScienceDirect, Web of Science, Scopus and Google Scholar and the reference lists of the retrieved articles until July 30, 2022. The eligible studies were selected using inclusion and exclusion criteria. The extracted data were verified and analysed using the random‐effect meta‐analysis.ResultFor this meta‐analysis, a total of 4372 rodents from 26 eligible studies were included. The global prevalence of N. caninum in rodents was estimated at 5% (95% CI 2%–9%), with the highest prevalence in Asia (12%; 95% CI 6%–24%) and lowest prevalence in America (3%; 95% CI 1%–14%) and Europe (3%; 95% CI 1%–6%). N. caninum was more prevalent in females (4%; 95% CI 2%–9%) than in males (3%; 95% CI 1%–11%). The most common diagnostic test was polymerase chain reaction (PCR) (21 studies). The pooled prevalence of N. caninum in rodents based on the diagnostic method was as follows: immunohistochemistry: 11% (95% CI 6%–20%), NAT: 5% (95% CI 4%–7%), IFAT: 5% (95% CI 2%–13%) and PCR: 3% (95% CI 1%–9%).ConclusionThe results of this study showed a relatively low but widespread prevalence of N. caninum infection in rodents.

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“…cattle, sheep, goats) and wildlife [ 1 , 2 ]. Infection with N. caninum has been reported to cause reproductive disorders in pregnant animals and neuromuscular disorders in newborn animals [ 3 , 4 ]. Notably, neosporosis, which is caused by N. caninum infection, was found to be one of the main causes of abortion in cattle [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Temporal transcriptomic changes in microRNAs involved in the host immune response and metabolism during Neospora caninum infection

et al. 2023

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Background Neospora caninum infection is a major cause of abortion in cattle, which results in serious economic losses to the cattle industry. However, there are no effective drugs or vaccines for the control of N. caninum infections. There is increasing evidence that microRNAs (miRNAs) are involved in many physiological and pathological processes, and dysregulated expression of host miRNAs and the biological implications of this have been reported for infections by various protozoan parasites. However, to our knowledge, there is presently no published information on host miRNA expression during N. caninum infection. Methods The expression profiles of miRNAs were investigated by RNA sequencing (RNA-seq) in caprine endometrial epithelial cells (EECs) infected with N. caninum at 24 h post infection (pi) and 48 hpi, and the functions of differentially expressed (DE) miRNAs were predicted by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. The transcriptome data were validated by using quantitative real-time polymerase chain reaction. One of the upregulated DEmiRNAs, namely chi-miR-146a, was selected to study the effect of DEmiRNAs on the propagation of N. caninum tachyzoites in caprine EECs. Results RNA-seq showed 18 (17 up- and one downregulated) and 79 (54 up- and 25 downregulated) DEmiRNAs at 24 hpi and 48 hpi, respectively. Quantitative real-time polymerase chain reaction analysis of 13 randomly selected DEmiRNAs (10 up- and three downregulated miRNAs) confirmed the validity of the RNA-seq data. A total of 7835 messenger RNAs were predicted to be potential targets for 66 DEmiRNAs, and GO and KEGG enrichment analysis of these predicted targets revealed that DEmiRNAs altered by N. caninum infection may be involved in host immune responses (e.g. Fc gamma R-mediated phagocytosis, Toll-like receptor signaling pathway, tumor necrosis factor signaling pathway, transforming growth factor-β signaling pathway, mitogen-activated protein kinase signaling pathway) and metabolic pathways (e.g. lysine degradation, insulin signaling pathway, AMP-activated protein kinase signaling pathway, Rap1 signaling pathway, calcium signaling pathway). Upregulated chi-miR-146a was found to promote N. caninum propagation in caprine EECs. Conclusions This is, to our knowledge, the first report on the expression profiles of host miRNAs during infection with N. caninum, and shows that chi-miR-146a may promote N. caninum propagation in host cells. The novel findings of the present study should help to elucidate the interactions between host cells and N. caninum. Graphical Abstract

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Prevalence and associated risk factors of Neospora caninum infection among cattle in mainland China: A systematic review and meta-analysis

Cited by 7 publications

References 46 publications

Seroprevalence of Neospora caninum infection and associated risk factors in cattle in Shanxi Province, north China

Seroprevalence of Neospora caninum infection and associated risk factors in cattle in Shanxi Province, north China

Global prevalence of Neospora caninum in rodents: A systematic review and meta‐analysis

Temporal transcriptomic changes in microRNAs involved in the host immune response and metabolism during Neospora caninum infection

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