Prevalence and Associated Risk Factors of Sarcopenia in Female Patients with Osteoporotic Fracture

Abstract

BackgroundWe determined the prevalence of sarcopenia according to fracture site and evaluated the associated risk factors in female patients with osteoporotic fractures.MethodsA total of 108 patients aged 50 years or older with an osteoporotic fracture (hip, spine, or wrist) were enrolled in this retrospective observational study. A diagnosis of sarcopenia was confirmed using whole-body densitometry for skeletal muscle mass measurement. Logistic regression analysis was used to analyze the risk factors for sarcopenia.ResultsOf 108 female patients treated for osteoporotic fractures between January 2016 and June 2017, sarcopenia was diagnosed in 39 (36.1%). Of these, 41.5% (17/41) had hip fractures, 35% (14/40) had spine fractures, and 29.6% (8/27) had distal radius fractures. Body mass index (BMI; P=0.036) and prevalence of chronic kidney disease (CKD; P=0.046) and rheumatoid arthritis (P=0.051) were significantly different between the groups. In multivariable analysis, BMI (odds ratio [OR], 0.76; 95% confidence interval [CI], 0.55–1.05, P=0.098) and CKD (OR 2.51; 95% CI, 0.38–16.2; P=0.233) were associated with an increased risk of sarcopenia; however, this was not statistically significant.ConclusionsThis study evaluated the prevalence of sarcopenia according to the fracture site and identified associated risk factors in patients with osteoporotic fractures. A longterm, observational study with a larger population is needed to validate our results.

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“…Although muscle atrophy and bone loss may occur simultaneously, bone fractures are often preceded by loss of muscle mass and strength. The endocrine functions of skeletal muscles [ 471 , 472 , 473 , 474 , 475 , 476 , 477 ], the tight bidirectional (patho) physiological muscle-bone cross-talk [ 142 , 209 , 478 , 479 , 480 , 481 , 482 , 483 , 484 , 485 , 486 , 487 , 488 , 489 , 490 , 491 , 492 ], and their shared genetics [ 493 , 494 , 495 , 496 ] are well recognized. Not surprisingly, RFs for OP and falls often coexist (up to 63% in patients with HF [ 497 ]).…”

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