Prevalence and associated metabolic factors of fatty liver disease in the elderly

Wang, Zhongli; Xu, Ming; Peng, Jianhong; Jiang, Li; Hu, Zhengguo; Wang, Hua; Zhou, Shiqing; Zhou, Rui; Hultström, Michael; Lai, En Yin

doi:10.1016/j.exger.2013.05.059

Cited by 60 publications

(50 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Also, there was statistically significant positive correlation between the degree ofsteatosis and cholesterol and LDL level and significant negative correlation with HDL. This is in agreement with Wang et al who found higher total cholesterol and LDL levelsin NASH patient, whereas the level of HDL was markedly lower (20) . In the current study there was significant correlation between the degree ofsteatosis and fasting blood glucose which is in agreement with Lankarani et al, whofound elevated levels of fasting blood sugar in patients with NAFLD (21) .…”

Section: Discussionsupporting

confidence: 82%

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Maher¹

2016

jmscr

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Maher¹

2016

jmscr

View full text Add to dashboard Cite

“…A chinese case-control study examined 4226 adults above 60 years of age from a previous cohort investigated and compared them to 3145 randomly selected younger controls (< 60 years) from the same cohort. NAFDL was higher in the elderly (26.7%) than in the non-elderly (22.8%) and similar in the elderly between men and women (26.6% vs 27.0%, P > 0.05) [8] . Similar results presented by a cross-sectional study of 6905 nonobese (BMI < 25) subjects.…”

Section: Epidemiologymentioning

confidence: 99%

Role of diet on non-alcoholic fatty liver disease: An updated narrative review

Papandreou

Andreou

2015

WJH

View full text Add to dashboard Cite

The purpose of this article review is to update what is known about the role of diet on non-alcoholic fatty liver disease (NAFLD). NAFLD is the most common cause of chronic liver disease in the developed world and is considered to be a spectrum, ranging from fatty infiltration of the liver alone (steatosis), which may lead to fatty infiltration with inflammation known as non alcoholic steatohepatitis While the majority of individuals with risk factors like obesity and insulin resistance have steatosis, only few people may develop steatohepatitis. Current treatment relies on weight loss and exercise, although various insulin-sensitizing medications appear promising. Weight loss alone by dietary changes has been shown to lead to histological improvement in fatty liver making nutrition therapy to become a cornerstone of treatment for NAFLD. Supplementation of vitamin E, C and omega 3 fatty acids are under consideration with some conflicting data. Moreover, research has been showed that saturated fat, trans-fatty acid, carbohydrate, and simple sugars (fructose and sucrose) may play significant role in the intrahepatic fat accumulation. However, true associations with specific nutrients yet to be clarified.

show abstract

“…[27][28][29][30] Conversely, in women, advancing age, menopausal status and MetS features are all independent predictors of NAFLD. 31,32 The lower prevalence of NAFLD which has been reported with advancing age in the elderly, 33 is potentially attributable to either selective mortality or development of cirrhosis (which generally loses steatosis).…”

Section: 15mentioning

confidence: 99%

“…Middle-aged and elderly individuals have a higher prevalence of fibrosing NASH. 35,36 Most studies, 20,32,[37][38][39] except one, 40 have reported that NASH is histologically more severe in women than in men.…”

Section: 15mentioning

confidence: 99%

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Lonardo

Bellentani

Argo

et al. 2015

Digestive and Liver Disease

399

318

View full text Add to dashboard Cite

We aimed to illustrate the epidemiology of nonalcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published through May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidemia", "familial heterozygous hypobelipoproteinemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".We found that age, sex and ethnicity are major physiologic modifiers of the risk of nonalcoholic fatty liver disease, along with belonging to "nonalcoholic fatty liver disease families" and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of nonalcoholic fatty liver disease risk. Compared to these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of nonalcoholic fatty liver disease.A better understanding of the epidemiology of nonalcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups.

show abstract

Prevalence and associated metabolic factors of fatty liver disease in the elderly

Cited by 60 publications

References 43 publications

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Nonalcoholic fatty liver disease (NAFLD) and Portal Hypertension in Egyptian Patients

Role of diet on non-alcoholic fatty liver disease: An updated narrative review

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Contact Info

Product

Resources

About