Prevalence and Associated Factors of Insulin Resistance in Adults from Maracaibo City, Venezuela

Abstract

Background and Aim. Insulin resistance (IR) is a prominent pathophysiologic component in a myriad of metabolic disorders, including obesity, prediabetes, and type 2 diabetes mellitus, which are common in our locality. The objective of this study was to determine the prevalence of IR and factors associated with this condition in an adult population from Maracaibo city, Venezuela. Methodology. A cross-sectional, descriptive study with multistaged randomized sampling was carried out in 2026 adults. IR was defined as HOMA2-IR ≥ 2. A multiple logistic regression model was constructed in order to evaluate factors associated with IR. Results. The prevalence of IR was 46.5% (n = 943), with 46.7% (n = 450) in the general population, 46.4% (n = 493) in females, and 47.90% (n = 970) in males (p = 0.895). IR prevalence tended to increase with age and was significantly greater in subjects aged ≥30 years (χ 2 = 16.726; p = 2.33 × 10−4). Employment, alcohol consumption, obesity, high triacylglycerides, low HDL-C, and dysglycemia were associated with greater odds of IR, whereas a high level of physical activity appeared to be weak protective factor against IR. Conclusions. The prevalence of IR is elevated in our locality. The main determinants of this condition appear to be the presence of obesity, high triacylglycerides, low HDL-C, dysglycemia, and alcohol intake.

Rice bran oil ameliorates hepatic insulin resistance by improving insulin signaling in fructose fed-rats

“…Insulin resistance syndrome is a cluster of related variables that included resistance to insulin-induced glucose uptake and hyperinsulinemia [20,21]. Insulin resistance occurs at multiple levels in cells, from the cell surface to the nucleus, including insulin receptor desensitization and suppression of IRS protein and functionality, all of which can result from inhibition of IRS1 and IRS2 [22].…”

Biochemical and clinical characterization of metabolic phenotypes: a cross-sectional study from Maracaibo city, Venezuela

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Indirect insulin resistance detection: Current clinical trends and laboratory limitations

“…There are few published studies on decision limits for insulin resistance indices, so this condition is recognized with different frequencies even based on the same indices. The most important factors influencing indices values are age, ethnicity origin and lifestyle, as well as the laboratory methods used for glucose and insulin concentration determination 10 . Because of the lack of official guidelines, efforts towards the determination of reference intervals of insulin resistance indices are still necessary for proper diagnosis 11 .…”