Prevalence and associated factors of comorbid anxiety disorders in late-life depression: findings from geriatric tertiary outpatient settings

Abstract

PurposeThe study evaluated the prevalence of comorbid anxiety disorders in late-life depression (LLD) and identified their associated factors.Patients and methodsThis study involved 190 elderly Thais with depressive disorders diagnosed according to the Mini-International Neuropsychiatric Interview (MINI). Anxiety disorders were also diagnosed by the MINI. The 7-item Hamilton Depression Rating Scale (HAMD-7), Montreal Cognitive Assessment, Geriatric Depression Scale (GDS), Core Symptoms Index, Neuroticism Inventory, Perceived Stress Scale and Multidimensional Scale for Perceived Social Support were completed. Descriptive statistics and ORs were used for analysis.ResultsParticipants included 139 females (73.2%) with a mean age of 68.39±6.74 years. The prevalence of anxiety disorders was 7.4% for generalized anxiety disorder (GAD), 4.7% for panic disorder, 5.3% for agoraphobia, 1.1% for social phobia, 2.1% for obsessive–compulsive disorder and 3.7% for post-traumatic stress disorder, with an overall prevalence of 16.84%. The comorbidity of anxiety disorders was associated with gender (P=0.045), history of depressive disorder (P=0.040), family history of depressive disorder (P=0.004), GDS (P=0.037), HAMD-7 (P=0.001), suicidality (P=0.002) and neuroticism (P=0.003). History of alcohol use was not associated.ConclusionThe prevalence of anxiety in LLD was comparable to other studies, with GAD and agoraphobia being the most prevalent. This study confirmed the role of depression severity and neuroticism in developing comorbid anxiety disorders.

The role of perceived stress and cognitive function on the relationship between neuroticism and depression among the elderly: a structural equation model approach

“…This finding suggests that it is worth including perceived stress as a variable in further studies exploring the relationship between neuroticism and cognition, whether they be cross-sectional or longitudinal. Previous studies have indicated the existence of the relationship between neuroticism, perceived stress, and depression in elderly people with clinical depressive disorder [55,56], and the present study supports the existence of such relationships among elderly people without clinically diagnosed depressive disorders. This might apply to the elderly at similar pre-operative periods (or in related clinical settings) as a means of mitigating the severity of depressive symptom, heightened perceived stress, or cognitive decline following operations which typically lead to increased morbidity or prolonged hospitalization [57].…”

Role of Neuroticism and Perceived Stress on Quality of Life among Patients with Dry Eye Disease

“…Investigators have supported the relationship between subjective complaints and feelings of stress and neuroticism [21]. In addition to perceived stress, neuroticism is closely related to anxiety and depression [43][44][45], that constitute high risk for worsening dry eye symptoms and poor QOL [5], but not included in this analysis.…”

Goldberg-en Antsietate eta Depresio Eskala: euskarazko egokitzapenaren ikerketa pilotua

“…Askotan bere aldetik ikertuak izan diren arren, depresioa zein antsietatea hertsiki erlazionatuta aurkitu dira. Hala, azterlan ezberdinek adierazi dute depresioa dutenen % 17-57k antsietate-nahasmenduren bat azaltzen duela eta, alderantziz, antsietatea dutenen % 13-28k aldibereko depresioa agertzen duela (Almeida et al, 2012;Beekman et al, 2000;Suradom et al, 2019;van Balkom et al, 2000). Komorbilitate hori dela-eta, nahasmendu zein sintoma depresibo eta antsiosoak ezberdintzeko gai diren neurriak garatzea garrantzitsua litzateke.…”

“…Ikerketa pilotu honen bigarren helburua, antsietatearen, depresioaren eta bien arteko komorbilitatearen prebalentzien kalkuluari zegokion. Aurkitutako prebalentziek bat egiten dute adineko pertsona egoitzaratuen osasun mentala aztertu duten ikerketen emaitzekin, antsietatearen kasuan (Bryant et al, 2008), depresioaren kasuan (Azeem eta Naz, 2015;Franco eta Monforte, 1996), bai eta komorbilitatearen kasuan ere (Suradom et al, 2019;van Balkom et al, 2000). Komorbilitatearekin lotuta, ikerlan honen hirugarren helburua izan da miatzea ea GADEak antsietatearen eta depresioaren artean erlazio esanguratsurik antzematen duen.…”

“…Komorbilitatearekin lotuta, ikerlan honen hirugarren helburua izan da miatzea ea GADEak antsietatearen eta depresioaren artean erlazio esanguratsurik antzematen duen. Analisiek bi aldagaien arteko korrelazio positiboa aurkitu dute, literatura zientifikoan aurkitutako emaitzen bidean (adib., Almeida et al, 2012;Beekman et al, 2000;Suradom et al, 2019). Lortutako emaitza horrek antsietatearen eta depresioaren arteko komorbilitatea azpimarratzen du.…”