Migrant workers usually encounter socio-economic and living hardships resulting in complex physical, social, and mental health problems. This research aimed to determine the influence of quality of life (QOL) and social capital on depression among Laotian migrants working in the Northeast of Thailand, which has not been studied on such issues before. This cross-sectional study analyzed the data from the previous study related to the quality of Life of Laotian Migrant Workers in the Northeast of Thailand, which was conducted among 1,477 respondents using a structured questionnaire interview. One thousand two hundred five participants passed the inclusion criteria for the analysis. The generalized linear mixed model was performed to identify the influence of QOL and social capital on depression when controlling the effects of co-variates, presenting adjusted OR and 95% confidence interval. Among 1,205 respondents, 9.29 % reported having depressive symptoms. The depressive symptom was significantly associated with having low to moderate levels of QOL, low to moderate levels of social capital. Other significant co-variates were high stress levels, chronic disease, work permit absence, menstruation lack, physical exercise absence, and living in a room for more than four people. Nearly one-tenth of Laotian migrant workers had depressive symptoms. Quality of life, social capital, stress, socio-economic, working and living conditions, health status, and health behaviors were associated with depression among those migrant workers working in the Northeast of Thailand.