Prevalence and associated factors of chronic kidney disease among adult hypertensive patients in Tigray teaching hospitals: a cross-sectional study

Bahrey, Degena; Gebremedhn, Gebreamlak; Mariye, Teklewoini; Girmay, Alem; Aberhe, Woldu; Hika, Assefa; Teklay, Girmay; Tasew, Hagos; Zeru, Teklay; Gerensea, Hadgu; Demoz, Gebre Teklemariam

doi:10.1186/s13104-019-4610-8

Cited by 19 publications

(23 citation statements)

References 15 publications

(21 reference statements)

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“…4 Institution-based studies in Ethiopia show that the prevalence of CKD ranges from 22.1% to 38.6%. [5][6][7] Chronic kidney disease leads to hypertension, anemia, vascular dysfunction, uremia, proteinuria, systemic inflammation, and oxidative stress that are associated with cognitive impairment. 8,9 Cognitive impairment is when a person has trouble remembering, learning new things, concentrating, or making decisions which is a common problem affecting CKD patients.…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Gela¹,

Getu²,

Adane³

et al. 2021

NDT

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Background: Cognitive impairment is one of the public health problems affecting 50 million people in the world. Chronic kidney disease (CKD) patients are at high risk to develop cognitive impairment which leads to poor quality of life, difficulty in adhering to medications, increased risk of mortality, and health resource utilization. However, there is no study done on the prevalence of cognitive impairment and associated factors among chronic kidney disease patients in Ethiopia. Objective: This study aimed to assess the prevalence of cognitive impairment and associated factors among chronic kidney disease patients at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020, Northwest Ethiopia, 2020. Methods: An institution-based comparative cross-sectional study was conducted at the University of Gondar Comprehensive Specialized and Felege Hiwot Referral Hospitals in 2020. A systematic random sampling technique was used to select the study participants. Data were collected using standard tools. Data were checked for its completeness and entered into Epi data version 3.0 then exported into STATA 14. Multi-variable logistic regression analysis was employed to identify associated factors of cognitive impairment among CKD patients, and variables having a p-value of ≤0.05 were declared as significant. Results: In this study, 116 CKD patients and 116 age, sex, and educational level matched controls were included with a response rate of 100%. The prevalence of cognitive impairment was 49.1% [95% CI (40%, 58.3%)] among CKD patients and 28.4% [95% CI (20.9%, 37.5%)] among controls. Independent predictors of cognitive impairment among CKD patients were estimated glomerular filtration (eGFR) <60mL/min/m 2 [AOR=3.9, 95% CI (1.1-14.74)], proteinuria [AOR=6.0, 95% 3)], age greater than 65 years [AOR=4.0, 95% CI (1.12-14.64)], and educational level of grade 8 and less [AOR= 4.7,]. Conclusion:The prevalence of cognitive impairment among CKD patients was higher than healthy controls. Cognitive impairment was higher among CKD patients with eGFR <60mL/ min/m 2 , proteinuria, educational level of grade 8 and less, and age greater than 65 years. Therefore, there is a need to have a regular evaluation and follow-up of CKD patients for cognitive impairment.

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Section: Introductionmentioning

confidence: 99%

Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Gela¹,

Getu²,

Adane³

et al. 2021

NDT

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“…A systematic review and meta-analysis were done on 12 articles that fulfilled the inclusion criteria ( Table 1 ). A total of 3766 patients (ranging from 163 26 to 568 18 ) with chronic illnesses were involved in this study. The included studies were published from 2013 27 up to 2020 20 , 28 ( Figure 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Although individual studies depicted age, 21 , 26 BMI, 18 , 21 , 26 and the presence of hypertension as a significantly associated factor to develop CKD. Our meta-analysis found only presence of hypertension being associated significantly.…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of chronic kidney disease and associated factors among patients with chronic illness in Ethiopia: A systematic review and meta-analysis

2022

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Objective: The main aim of this systematic review and meta-analysis is to provide summarized evidence on the prevalence of chronic kidney disease and associated factors among patients with chronic illness in Ethiopia. Method: Databases of MEDLINE/PubMed, Embase, Google Scholar, CINAHL, Cochrane library, and ScienceDirect were searched. In addition, gray literatures were searched manually from university repositories. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist was used to select potential studies. Microsoft Excel 2013 sheet template was used to extract data. The quality of included studies was assessed by utilizing the Newcastle-Ottawa Scale. STATA software version 14.0 is used to compute the estimated pooled prevalence and associated factors of chronic kidney disease. Result: Twelve articles that fulfilled the inclusion criteria were included. The pooled estimate of chronic kidney disease among patients with chronic illnesses in Ethiopia is 21.71% (95% confidence interval: 17.67, 25.74). The highest prevalence of chronic kidney disease among patients with chronic illnesses is from Oromia (32.55% (confidence interval: 19.91, 45.19)). Glomerular filtration rate showed a comparable pooled prevalence from Cockroft-Gault and MDRD methods; 22.38% (confidence interval: 15.83, 28.92), 22.18 (confidence interval: 18.01, 26.34), respectively. Hypertensives become more likely to have chronic kidney disease compared with normotensive patients, (odds ratio = 3.01, 95% confidence interval: 1.33, 6.81). Conclusion: Prevalence of chronic kidney disease among chronic illness patients was significantly high. Hypertension is significantly associated with chronic kidney disease. Hence, we recommend that continuous screening of possible risk factors and proper follow-up and management strategies should be designed.

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“…Most (64.6%) hypertensive patients reported overweight/obesity of which 76.7% had uncontrolled hypertension, this ndings are higher than a study done in Dar-es Salaam, Tanzania where the prevalence of overweight/obesity was 67.2% and lower than a cross-sectional study in Mwanza, Tanzania which reported a prevalence of 92.2% (19,42). Overweight and obesity had 6fold increased odds for uncontrolled hypertension; Tanzania and other countries in the third world are undergoing epidemiological transition associated with urbanization and sedentary life style with increasing obesity, dyslipidemia, hypertension, diabetes, ischaemic heart disease and CKD (16,27,43,44). This discrepancy in prevalence in these studies can be attributed to differences in study populations and extent of urbanization between the cities.…”

Section: Discussionmentioning

confidence: 99%

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

Katatwire

Meremo

2022

Preprint

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Background The prevalence of uncontrolled hypertension has been increasing globally including Sub-Saharan Africa (SSA) accelerating the burden of chronic kidney disease (CKD), cardiovascular diseases (CVD) and non-communicable diseases (NCDs). Methods A cross-sectional study was conducted among adult patients with early-stage CKD attending the medical outpatient department (MOPD) clinics of two tertiary hospitals in Dodoma between November 2020 to March 2021. Descriptive and inferential statistics were performed using SPSS software version 26 and multivariable logistic regression analysis was used to identify variables associated with uncontrolled hypertension. Results A total of 352 patients were enrolled; 64 (18.2%) were in CKD stage 2 and 288 (81.8%) in CKD stage 3, median age was 54 (47–59) years, 182 (51.7%) were males, the prevalence of hypertension was 58.5% and the prevalence of uncontrolled hypertension was 58.3%. For patients with uncontrolled hypertension, the median SBP was 146 (142–150) mmHg, the median DBP was 86(82–90) mmHg, the median BMI was 26.1 (24.0-27.5) kg/m2, the median waist circumference was 97(90–104) cm, the median eGFR of 48 (43–55) mil/min/1.73m2. Among patients with uncontrolled hypertension; 88.3% patients had CKD stage 3, 80.0% patients reported non-adherence to antihypertensives, 76.7% patients had overweight/ obesity, 72.5% patients reported current alcohol use, 60.0% patients had dyslipidemia, 43.3% patients reported current smoking, 36.7% patients had significant proteinuria and 26.7% patients had diabetes mellitus. Variables with higher odds for uncontrolled hypertension were; age ≥ 50 years (OR = 5.17, 95% CI 2.37–13.33, P = 0.001), alcohol use (OR = 11.21, 95% CI 3.83–32.84, P = 0.001), Overweight/obesity (OR = 6.28, 95% CI 2.54–15.53, P = 0.001), non-adherence to antihypertensives (OR = 10.19, 95% CI 4.22–24.61, P = 0.001) and CKD stage 3 (OR = 3.52, 95% CI 1.32–9.42, P = 0.012). Conclusion Uncontrolled hypertension is highly prevalent among patients with early-stage CKD in our settings and it’s associated with age, current alcohol use, overweight/obesity and non-adherence to antihypertensives.

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Prevalence and associated factors of chronic kidney disease among adult hypertensive patients in Tigray teaching hospitals: a cross-sectional study

Cited by 19 publications

References 15 publications

Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Cognitive Impairment and Associated Factors Among Chronic Kidney Disease Patients: A Comparative Cross-Sectional Study

Prevalence of chronic kidney disease and associated factors among patients with chronic illness in Ethiopia: A systematic review and meta-analysis

High prevalence of uncontrolled hypertension among patients with early chronic kidney disease attending tertiary hospitals in Dodoma, Tanzania

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