Prevalence and Associated factors of Tardive Dyskinesia among patients with schizophrenia taking Antipsychotics

Abstract

1.1. Objective: Tardive dyskinesia (TD) is one of incapacitating side effect of neuroleptics. It has been implicated in the morbidity, functional impairment, stigma and overall poor prognosis of patients with schizophrenia. However, there is little information from Ethiopia. Therefore, we conducted a cross-sectional study among 161 schizophrenia patients who were admitted and on follow up at two public hospitals in Addis Ababa. We assessed TD using the Abnormal Involuntary Movement Scale. Associated factors Were also analyzed. 1.2. Results: Out of the total study participants, 41(25.5%) have TD. Clinical characteristics variables such as depot antipsychotics, combination of antipsychotics, Chlorpromazine equivalent dose of 400 mg or more and substance use were significantly associated with TD (P – value < 0.05). Nearly half of those with TD had moderate to severe TD which has significant negative impact on their day-to-day activities. 1.3. Conclusion: Prevalence of TD among schizophrenia patients taking antipsychotics is high. Root of administration and higher dose of antipsychotic medication and substance use were found to be factors associated. Rational use of antipsychotics and regular screening for TD for patients who takes antipsychotics is recommended.