Prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia

Abstract

BackgroundThe initiation of highly active antiretroviral therapy (HAART) plays a significant role in the clinical management of HIV infected people by preventing morbidity and mortality. This benefit becomes, the most terrible when treatment failure develops. Thus, this research aims to assess the prevalence and associated factors of treatment failure among HIV/AIDS patients on HAART attending University of Gondar Referral Hospital Northwest Ethiopia.ResultsPatients on ART with a minimum of 6 months and up to 12 years of treatment were being enrolled. The prevalence of treatment failure, immunological failure and virological failure among people living with HIV/AIDS attending University of Gondar referral hospital were 20.3, 13.2, and 14.7%, respectively. Patients who had no formal education (Adjusted odds ratio (AOR): 3.8; 95% CI, 1.05–13.77), primary level education (AOR: 4.2; 95% CI, 1.16–15.01) and duration on ART < 6 years (AOR: 2.1; 95%CI, 1.12–3.81) were a significant risk factor. However, initial adult regimen D4T + 3TC+ EFV (AOR: 0.025; 95% CI, 0.002–0.36), AZT +3TC + NVP (AOR: 0.07; 95% CI, 0.01–0.71), AZT + 3TC + EFV (AOR: 0.046; 95% CI, 0.004–0.57) andTDF+3TC + EFV (AOR: 0.04; 95% CI, 0.004–0.46) were significantly protective for treatment failure.ConclusionsTimely and early identification of associated factors and monitoring antiretroviral therapy treatment failure should be done to enhance the benefit and to prevent further complication of the patients. It is preferable to initiate ART using any one of the following ART regimens: AZT +3TC + NVP, AZT + 3TC + EFV and TDF + 3TC + EFV to prevent treatment failure. Since the prevalence of this treatment failure and its associated factor may be different from other ART centers and community in Ethiopia, further national representative institutional based cross-sectional researches are needed across all ART centers of Ethiopia in order to determine the prevalence of treatment failure and its associated factors.

Factors Associated with Adverse Therapeutic Outcomes in People Living with HIV (PLHIV) Monitored in Roi Baudouin Health Care Center, Dakar, Senegal

“…This association corroborates what has been described in several studies [38] [39]. The reasons which are mostly mentioned in the non-optimization of ART in the young subject are the low compliance [40], the long duration of exposure [41], the inadequacy of dosage [42]. Thus, it is necessary to reinforce therapeutic education sessions for better adhesion of adolescents but also to conduct mainly qualitative studies aimed at clarifying the factors of treatment adverse events in young people.…”

Magnitude of antiretroviral treatment failure and associated factors among adult HIV-positive patients in Harar public hospitals, Eastern Ethiopia

“…Previous study also supports this finding. 13 Patients who were on WHO stages 3 and 4 during initiations of ART have higher odds of treatment failure. This result is similar to the study reported from Southern Ethiopia.…”

Prevalence and Factors Associated with Virologic Failure among People Living with HIV (PLHIV) Monitored in a Decentralized Health Care Facility

“…[19] [24] [35], virologic failure in our series was associated with late monitoring. This suggests a constant advocacy among treatment providers for the early initiation of ART, which have proven to be effective both individually and collectively[4] [5].…”

“…Faso [18] and Cameroon [14]. On the other hand, a smaller prevalence has been described in Ethiopia [24], Nigeria [25], South Africa [26] and Uganda [27] with a prevalence of 14.7%, 13.7%, 13.7% and 11.3%, respectively.…”