Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease

Mussele, Stefan Van der; Bekelaar, Kim; Bastard, Nathalie Le; Vermeiren, Yannick; Saerens, J.; Somers, Nore; Mariën, Peter; Goeman, Johan; Deyn, Peter Paul De; Engelborghs, Sebastiaan

doi:10.1002/gps.3909

Cited by 67 publications

(65 citation statements)

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“…In contrast, van der Mussele et al [33] found the prevalence of depressive symptoms to be significantly higher among those with AD dementia than those with MCI (25 vs. 16%). As suggested by the range of depression prevalence rates reported in previous studies, variations in prevalence rates and findings regarding the association between depression and dementia are partly attributable to differences in study design as well as the methods employed to assess depression (e.g.…”

Section: Discussionmentioning

confidence: 89%

“…It is also within the range of 25-66% reported in four separate studies of community-based populations (vs. institutionalized or hospitalized) with diagnosed dementia that have employed different instruments to assess depressive symptomatology. Specifically, a 25% prevalence rate of depressive symptoms as assessed with the Cornell Scale for Depression in Dementia (CSDD) was reported in a study of memory clinic patients diagnosed with dementia due to AD [33]; among individuals diagnosed with probable AD dementia, a prevalence rate of 40% was reported as assessed with the Columbia University Scale for Psychopathology in Alzheimer's Disease (CUSPAD) [34]; a 49% prevalence rate of depressive symptoms was assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS) among individuals referred to outpatient clinics specializing in geriatrics and older psychiatry diagnosed with a dementia type [35], and a prevalence rate of 66%, also assessed with the MADRS, was reported in a study of memory clinic patients diagnosed with early-onset dementia [36]. …”

Section: Discussionmentioning

confidence: 99%

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Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Kosteniuk

Morgan

O’Connell³

et al. 2014

Dement Geriatr Cogn Disord Extra

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Background/Aims: To estimate the prevalence, severity, and covariates of depressive symptoms in rural memory clinic patients diagnosed with either mild cognitive impairment (MCI) or dementia. Methods: In a cross-sectional study of 216 rural individuals who attended an interdisciplinary memory clinic between March 2004 and July 2012, 51 patients were diagnosed with MCI and 165 with either dementia due to Alzheimer's disease (AD) or non-AD dementia. The Center for Epidemiologic Studies of Depression Scale (CES-D) was used to estimate the severity and prevalence of clinically elevated depressive symptomatology. Results: The prevalence of elevated depressive symptoms was 51.0% in the MCI patients and 30.9% in the dementia patients. Depressive symptoms were more severe in the MCI patients than in the dementia patients. Elevated depressive symptoms were statistically associated with younger age for the MCI group, with lower self-rated memory for the dementia group, and with increased alcohol use and lower quality of life ratings for all patients. In the logistic regression models, elevated depressive symptoms remained negatively associated with self-rated memory and quality of life for the patients with dementia, but significant bivariate associations did not persist in the MCI group. Conclusions: The high prevalence and severity of depressive symptoms among rural memory clinic patients diagnosed with either MCI or dementia warrant continued investigation.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Kosteniuk

Morgan

O’Connell³

et al. 2014

Dement Geriatr Cogn Disord Extra

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“…These disruptions may disorganize serotonergic and dopaminergic neurotransmitters in frontal-subcortical pathways and impact behavior. Thus, depressive symptoms in MCI and AD patients become clinically relevant and reflect dysfunctions in the frontal lobe with associated behavioral manifestations -agitation, disinhibition, and restlessness 15 . Our findings of a correlation between affective syndrome and frontal atrophy are also supported by information from the literature.…”

Section: Discussionmentioning

confidence: 99%

Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease

Hayata

Bergo

Rezende

et al. 2015

Arq. Neuro-Psiquiatr.

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Neuropsychiatric syndromes (NPS) in dementia due to Alzheimer' s disease (AD) have received growing attention across clinical centers and research settings in the last few decades. The high prevalence of NPS and their increasing severity in AD patients aggravate the disease' s course and cause distress for caregivers. These symptoms, once considered secondary behavior due to cognitive and functional impairment in dementia, have shown patterns of temporal course, which do not necessarily follow the linear decline of cognitive impairment.Several NPS seem to be more prevalent and clinically prominent in distinct stages of the disease. Depression is the most common syndrome in mild-to-moderate AD, while delusions, hallucinations, and aggression seem to be more common as the disease progresses, whereas apathy remains across all stages of AD, worsening as the global deterioration aggravates. However, these manifestations, also detected in mild cognitive impairment (MCI), increase the risk of dementia and may occur in prodromal AD.Moreover, aberrant vocalizations commonly emerge when patients are in advanced stages of dementia. Despite the fact that NPS and cognitive alterations may considerably overlap, these findings suggest distinct etiologies for both conditions. Furthermore, over the course of the disease, the prevalence of NPS reaches 50-90% of patients with dementia AbstrACtNeuropsychiatric symptoms in Alzheimer's disease (AD) are prevalent, however their relationship with patterns of cortical atrophy is not fully known. Objectives: To compare cortical atrophy's patterns between AD patients and healthy controls; to verify correlations between neuropsychiatric syndromes and cortical atrophy. Method: 33 AD patients were examined by Neuropsychiatric Inventory (NPI). Patients and 29 controls underwent a 3T MRI scanning. We considered four NPI syndromes: affective, apathy, hyperactivity and psychosis. Correlations between structural imaging and neuropsychiatric scores were performed by Freesurfer. Results were significant with a p-value < 0.05, corrected for multiple comparisons. Results: Patients exhibited atrophy in entorhinal cortices, left inferior and middle temporal gyri, and precuneus bilaterally. There was correlation between affective syndrome and cortical thickness in right frontal structures, insula and temporal pole. Conclusion: Cortical thickness measures revealed atrophy in mild AD. Depression and anxiety symptoms were associated with atrophy of right frontal, temporal and insular cortices.Keywords: depression, anxiety, MRI, neurodegenerative disease, neuropsychiatry. resumo Os sintomas neuropsiquiátricos na doença de Alzheimer (DA) são prevalentes, porém suas relações com padrões de atrofia cortical não são totalmente compreendidas. Objetivos: Comparar padrões de atrofia cortical entre DA e controles; verificar se há correlações entre sintomas neuropsiquiátricos e atrofia cortical. Método: 33 pacientes com DA foram examinados pelo Inventário Neuropsiquiátrico. Os pacientes e 29 controles foram submeti...

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“…In the same study, individuals with better education backgrounds performed better in memory tests, and lower education was associated with depressive symptoms [33]. Behavioral symptoms and frontal lobe alterations were more prevalent in patients with mild cognitive impairment, AD, and depressive symptoms when compared to patients without depressive symptoms [34].…”

Section: Accepted Manuscriptmentioning

confidence: 95%

Neurochemical correlation between major depressive disorder and neurodegenerative diseases

et al. 2016

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Prevalence and associated behavioral symptoms of depression in mild cognitive impairment and dementia due to Alzheimer's disease

Abstract: Frontal lobe and behavioral symptoms are more prevalent and severe in MCI and AD patients with significant depressive symptoms as compared with patients without depressive symptoms.

Cited by 67 publications

References 47 publications

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Prevalence and Covariates of Elevated Depressive Symptoms in Rural Memory Clinic Patients with Mild Cognitive Impairment or Dementia

Cortical correlates of affective syndrome in dementia due to Alzheimer’s disease

Neurochemical correlation between major depressive disorder and neurodegenerative diseases

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