Prevalence and antimicrobial susceptibility of asymptomatic bacteriuria among women with pelvic organ prolapse in Abakaliki, South-East Nigeria

Ekwedigwe, Kenneth Chinedu; Sunday-Adeoye, Ileogben; Eliboh, M. O.; Isikhuemen, M. E.; Uro-Chukwu, Henry Chukwuemeka; Ezeonu, Paul Olisaemeka; Daniyan, A. B. C.; Yakubu, Emmanuel

doi:10.1186/s12905-018-0545-9

Cited by 7 publications

(7 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…coli was the most frequent etiological agent of UTI, accounting for up to 37.6% of isolated cases. This nding is in agreement with the ndings from Nigeria, 34.2% [30] and India, 37.3% [31]. The possible explanation for this high isolation rate of E. coli in the present nding could be due to the signi cant abundance of E. coli in the rectal area, which in turn via contamination ascends through genitalia to the urinary tract and causes UTI and it could also be due to E. coli having various enhanced virulence factors speci c for colonization and invasion of the urinary epithelium, such as P-mbriae and S-mbriae adherence factors which mediate the attachment of E. coli to viginal and uroepithelial cells [32].…”

Section: Discussionsupporting

confidence: 93%

Uropathogenic bacterial profile and antibiotic susceptibility pattern of isolates among gynecological cases admitted to Jimma Medical center, South West Ethiopia

Teferi¹,

Sahlemariam

Mekonnen

et al. 2022

Preprint

View full text Add to dashboard Cite

Background: Urinary tract infection (UTI) is one of the most common bacterial infections in women; about 50% of women get during their life time. Moreover, it is a common health problem in patients with gynecological pathologies, which increases the chance of acquiring infection. The aim of this study was to determine the bacterial profile that causes UTI and their antibiotic susceptibility pattern among admitted gynecological cases. Methods: A cross-sectional study was conducted in south west Ethiopia region. A total of 386 patients admitted with gynecological cases were included and structured questionnaire was used to collect socio-demographic and risk factor-related data. About 10ml freshly voided midstream and catheterized urine specimens were collected using sterile containers. Identification of isolate was done using culture characteristics, gram staining, and a series of biochemical tests. The data obtained were entered into EpiData Version 3.1 and analyzed using SPSS Version 25. A P-value of less than 0.05 was used as a level of significance. Results: In this study, the overall prevalence of UTI was 25.4%. E. coli was the most frequently isolated bacteria, which accounted for 38(37.6%), followed by Klebsiella species 22(21.8%), CONS 14(13.9%), S. aureus 10(9.9%), Enterobacter species 6(5.9%), Citrobacter species 5(4.9%), P. mirabilis 4 (4%), and P. aeroginosa 2(2%). Histories of UTI (AOR = 1.977, 95% CI: 1.06, 3.68, P = 0.032) and catheterization (AOR = 2.38, 95% CI: 1.28, 4.45, P = 0.006) were found to be statistically associated with significant bacteriuria. Gram-negative isolates showed a high level of resistance, 88.3% for ampicillin and 66.2% for tetracycline, and a relatively low level of resistance against ceftazidime, 22.1%, and meropenem, 3.9%. Gram-positive uropathogens showed a high level of resistance to penicillin, 91.6%, whereas all isolates were sensitive 100.0% to nitrofurantoin. Furthermore, 80 (79.2%) of the isolates had multidrug resistance, and 16 (26.7%) of both E. coli and Klebsiella spp. produced Extended Spectrum β-lactamase. Conclusion: In this study, a high prevalence of uropathogenic bacteria and multidrug resistance for commonly prescribed drugs were observed with a significant number of Extended Spectrum β-lactamase producers.

show abstract

Section: Discussionsupporting

confidence: 93%

Uropathogenic bacterial profile and antibiotic susceptibility pattern of isolates among gynecological cases admitted to Jimma Medical center, South West Ethiopia

Teferi¹,

Sahlemariam

Mekonnen

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…In this study as shown in table 1, of the 263 positive culture, E. coli 109 (41.44%) and K. pneumoniae 85 (32.32%) were the most predominant bacteria were responsible of asymptomatic bacteriuria, while S. saprophyticus was the lowest predominant bacteria 8 (30.06%). These results are in agreement with previous studies [22,23]. Many members of enterobacteriaceae such as E. coli, K. pneumoniae, P. aeruginosa and A. baumannii are able to cause recurrent urinary tract infections lead to asymptomatic bacteriuria [24,25].…”

Section: Discussionsupporting

confidence: 93%

Antimicrobial sensitivity pattern of pathogenic bacteria isolated from older women with asymptomatic bacteriuria

Aljanaby¹,

Aljanaby²

2018

biomedicalresearch

View full text Add to dashboard Cite

Objectives: Asymptomatic bacteriuria is one of the most important silent diseases frequently infect women in worldwide. Aims: To determine the antimicrobial susceptibility pattern of pathogenic bacteria isolated from older women with asymptomatic bacteriuria. Materials and methods: A total of 263 culture positive bacterial isolates from 862 urine samples were collected from older women (60-70 years old) admitted to Al-Najaf hospital in Al-Najaf Governorate, Iraq during January 2016 to December 2017. All bacterial isolates were identified according to standard microbiological tests. Antimicrobial susceptibility test was done according to method by Kirby-Bauer. Results: Out of 263 culture positive urine samples, Escherichia coli was the most dominant bacterial isolates 109 (41.44%) followed by Klebsiella pneumoniae 85 (32.32%), Acinetobacter baumannii 32 (12.16%), Pseudomonas aeruginosa 18 (6.84%), Serratia marcescens 11 (4.18%) and Staphylococcus saprophyticus 8 (3.06%). Among all antimicrobials, Imipenem 10 µg showed the highest activity (100%) against E. coli, S. marcescens and S. saprophyticus isolates While, Amikacin 30 µg showed the highest activity (100%) against S. marcescens only. Most bacterial isolates 240 (91.3%) were multi-drug resistance (MDR), 16 isolates (6%) and 7 isolates (2.7%) were extensive drug-resistance (XDR) and pandrug-resistance (PDR), respectively. Conclusions: There were many older women infected with asymptomatic bacteriuria caused by bacteria with high resistant to different antimicrobials; therefore, the antimicrobial sensitivity test must be done periodically.

show abstract

“…e similarities and differences in the type and distribution of uropathogens show a discrepancy from country to country due to many factors such as environmental conditions, health practices, patient conditions, personal hygiene, number of patients examined, and laboratory procedures [15]. Finding that E. coli is still the main causative agent of UTI in pregnant women could be explained by the fact that it is a normal flora in the lower gastrointestinal tract, although its implication is a concern as it causes diarrhoea, a threat for dehydration in pregnant women [33,34]. e prevalence of the resistance of the different drugs was determined and indicated quite high level of resistance for drugs such as ciprofloxacin and chloramphenicol that are commonly prescribed.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Resistance among Pregnant Women with Urinary Tract Infections Attending Antenatal Clinic at Levy Mwanawasa University Teaching Hospital (LMUTH), Lusaka, Zambia

Yeta

Michelo

Jacobs

2021

International Journal of Microbiology

View full text Add to dashboard Cite

Introduction. Globally, there is a growing concern over antimicrobial resistance (AMR) which is currently estimated to account for more than 700,000 deaths per year worldwide. AMR undermines the management of infectious diseases in general especially in pregnancy where significant bacteriuria continues to be a serious cause of maternal and perinatal morbidity and mortality. We therefore aimed to determine the prevalence of AMR and the associated factors among pregnant women with urinary tract infections (UTIs) attending antenatal clinic at a selected hospital in Lusaka, Zambia. Methods. This was a hospital-based, cross-sectional study conducted between November 2018 and May 2019. Interviewer-administered questionnaire was used to assess the sociodemographic characteristics and behavioural characteristics. Laboratory tests were also conducted. Descriptive statistics of study participants were used to describe the characteristics of the respondents. Chi-square was used to assess the association between categorical variables. The logistic regression analysis was carried out to generate the adjusted odds ratio with 95% confidence interval. Results. Overall (n = 203), the prevalence of UTI was 60% (95% CI: 53.3%–66.7%). The most isolated bacteria were E. coli (59%) and Klebsiella (21%). The prevalence of AMR was found to be 53% (95% CI: 46.1%–59.8%). The drugs highly resistant to antimicrobials were nalidixic acid (88.3%), ampicillin (77.8%), and norfloxacin (58.5%), while the least resistant drug was chloramphenicol (20%). There were no important significant predictors to AMR among pregnant women observed in this study. Conclusion. We found high burden of AMR closely linked to observe high prevalence of UTI suggested in this small population. This suggests a need to develop integrated surveillance systems that aim for early and regular screening of pregnant women for UTI as well as concurrent determination of antibiotic susceptibility patterns. This is important to prevent complications that may endanger maternal and fetal health outcomes. Furthermore, further research is needed to explore reasons for this high prevalence of AMR including examining possible attribution to the misuse of drugs so as to inform, enforce, or adjust the prescription-only policies and enforce antimicrobial stewardship programs.

show abstract

Prevalence and antimicrobial susceptibility of asymptomatic bacteriuria among women with pelvic organ prolapse in Abakaliki, South-East Nigeria

Cited by 7 publications

References 14 publications

Uropathogenic bacterial profile and antibiotic susceptibility pattern of isolates among gynecological cases admitted to Jimma Medical center, South West Ethiopia

Uropathogenic bacterial profile and antibiotic susceptibility pattern of isolates among gynecological cases admitted to Jimma Medical center, South West Ethiopia

Antimicrobial sensitivity pattern of pathogenic bacteria isolated from older women with asymptomatic bacteriuria

Antimicrobial Resistance among Pregnant Women with Urinary Tract Infections Attending Antenatal Clinic at Levy Mwanawasa University Teaching Hospital (LMUTH), Lusaka, Zambia

Contact Info

Product

Resources

About