Prevalence and Antifungal Susceptibility Patterns of Yeast Isolates at the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana

Feglo, Patrick Kwame; Narkwa, Patrick Williams

doi:10.9734/bmrj/2012/861

Cited by 24 publications

(29 citation statements)

References 23 publications

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“…A prevalence of 22% in both adolescent and adults has been reported in the USA (Reed, 1992). A similar result was obtained in a study in Ghana where 21% prevalence was reported (Abruquah, 2012;Feglo and Narkwa, 2012). The high incidence rate (25.0%) recorded in the 23-25 age group in our study agrees with the 25.6% reported by Abruquah (2012) in Ghana among a similar age group.…”

Section: Methodssupporting

confidence: 91%

Incidence and Speciation of Candida Species among Non-gravid young Females in Ilorin, North Central, Nigeria

Oyeyipo¹,

Onasoga²

2016

Journal of Applied Sciences and Environmental Management

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This study investigated the incidence and speciation of Candida species among non-gravid young females, using commercially available chromogenic Candida speciation media (CHROM agar) for the identification/speciation of medically important yeast and yeastlike organisms in a routine clinical mycology laboratory. High Vaginal Swabs (HVS) were randomly collected from consenting non-gravid-young females for the study. The participants also completed a structured questionnaire assessing demographic data, symptoms, and risk factors of candidiasis. A total of 120 females between the ages of 17 and 31 years were randomly recruited for the study. Standard microbiological techniques such as Gram's stain, wet mount and culture on Sabouraud Dextrose Agar (SDA) and CHROM agar were used to analyze the swabs. Candida species was isolated from 64 of the 120 females, representing 53.3%. The highest incidence rate of 25.0% was recorded in the 23-25 years age group, followed by 12.5% in the 26-28 years while the lowest incidence (1.7%) was observed in the 17-19 years age group. Candida albicans (35.0%) was the most common Candida species, followed by C. tropicalis (8.3%), C. glabrata (6.7%) and C. krusie (3.3%), whereas, non-Candida infection constituted 46.7% (Negative cultures). Vaginal discharge (85.5%) and itching (52.5%) recorded the high values, with respect to symptoms. The prevalent risk factors associated with vaginal candidiasis in this study were washing of vagina with soap (Vaginal douching) (72.5%) and unprotected casual sex (16.7%). Whitish vaginal discharge (78.3%) was most prevalent followed by creamish vagina discharge (56.7%). In addition to Candida albicans, non-albicans Candida spp were isolated from HVS specimens; therefore, public health education is vital. CHROM agar is a simple, rapid and inexpensive method with good sensitivity and specificity for identification and speciation of Candida species thus, allowing an early and appropriate antifungal therapy. The results of the study will eliminate the ambiguities concerning Candida identification in this country and will contribute to better management and proper treatment of patients. ©JASEM

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Section: Methodssupporting

confidence: 91%

Incidence and Speciation of Candida Species among Non-gravid young Females in Ilorin, North Central, Nigeria

Oyeyipo¹,

Onasoga²

2016

Journal of Applied Sciences and Environmental Management

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“…Similarly, C. tropicalis has previously been shown to account for 18% of cases of VVC in Nigeria (Okungbowa et al, 2003) and C. parapsilosis for 10% of cases in India (Ahmad and Khan, 2009). These values are comparable to those of the present study, and that of Feglo and Narkwa (2012), and again these are higher than the reports of 1-2% for C. tropicalis and 1-4% for C. parapsilosis elsewhere in the world (Achkar and Fries, 2010).…”

Section: Discussionsupporting

confidence: 85%

“…glabrata has been shown to account for 37% of cases of VVC in India (Ahmad and Khan, 2009) 34% of cases in Nigeria (Okungbowa et al, 2003), 30% of cases in Turkey (Cetin et al, 2007) and 18% of cases in a previous study at Komfo Anokye (Feglo and Narkwa, 2012). We report values of between 15.3 and 27.6% with an overall presence in 21.6% of patients present for the first time, and values of between 17.4 and 30% with an overall frequency of 24.4% for patients who have presented on at least three previous occasions.…”

Section: Discussionmentioning

confidence: 99%

“…Urine specimens were processed as described by Feglo and Narkwa (2012). Mid stream urine specimens were taken from patients with suspected urinary tract infections after explanation of the urine collection procedure to them.…”

Section: Methodsmentioning

confidence: 99%

“…There have been few studies of Candida species in Ghana or indeed in North West Africa as a whole. This is problematic, given that a rich variety of species including C. albicans, C. glabrata, C. tropicalis, Candida dubliniensis, C. krusei, Candida sake, Candida guilliermondii and C. parapsilosis have recently been described in samples taken from patients in a teaching hospital in Ghana (Feglo and Narkwa, 2012). The aim of this study was to expand on these findings and to identify and characterize Candida species in patients with infections of the lower and upper reproductive tract with VVC or PID and urinary tract infections from three major teaching hospitals in different parts of Ghana.…”

Section: Introductionmentioning

confidence: 99%

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An investigation of the distribution of Candida species in genitourinary candidiasis and pelvic inflammatory disease from three locations in Ghana

Hale¹,

Garrill²

2014

Afr. J. Microbiol. Res.

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The aim of this study was to determine the frequency of various Candida species in cases of genitourinary candidiasis and pelvic inflammatory disease (PID) in Ghana. To achieve this, Candida isolates were recovered from high vaginal swabs of patients with vulvovaginal candidiasis (VVC), urine samples from patients with urinary tract infections (UTIs) and endocervical swabs from patients with PID, from three teaching hospitals in Ghana. The hospitals were located at Korle Bu, Komfo Anokye and Tamale. These isolates were identified to the species level on the basis of the color of the colonies that they formed on chromogenic medium. Candida albicans was the most common species in high vaginal swabs from patients present for the first time with VVC in each of the three locations, and was present in 53.4% of the total swabs. The other species that were present were Candida glabrata (21.6%), Candida parapsilosis (15.5%), Candida tropicalis (4.7%) and Candida krusei (4.7%). Only single species were found in these swabs. In patients with VVC for at least the third time, Chi square analysis indicated that the frequency of each of these species were not statistically different from those present for the first time, although 15% of the swabs from these patients contained more than one species. For all patients with VVC, no significant differences were observed in the frequencies of the species between the three locations. Similar distributions were found in swabs taken from patients with PID. Across the three locations however, there was a significant difference in the frequency of C. albicans, which was present in 68 and 69.6% of patients from Komfo Anokye and Tamale, but only 26.7% of patients from Korle Bu. Twenty one percent of swabs from patients with PID contained more than one species. Urine samples were also collected from two of the locations, Korle Bu and Tamale, in female patients with candiduria. In Korle Bu, C. glabrata was the most prominent species (37.8%) followed by C. albicans (22.4%), C. parapsilosis (21.7%), C. tropicalis (10.5%), C. krusei (7%) and Candida lusitaniae (0.7%). In Tamale, the species distribution was C. albicans (60.9%), C. glabrata (21.7%), C. parapsilosis (13%) and C. krusei (4.3%). Statistical analysis indicated a significant difference in the frequency of C. albicans between the two locations. Fourteen percent of the urine samples contained more than one species. Taken as a whole, these data highlight a relatively high prevalence of species other than C. albicans, in cases of genitourinary candidiasis and PID in Ghana. This is consistent with a trend towards the emergence of other Candida species that may be more resistant to the first line antifungal treatments.

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Species distribution and antifungal susceptibility of Candida spp. isolated from superficial candidiasis in outpatients in Iran

Razzaghi-Abyaneh

Sadeghi

Zeinali

et al. 2014

Journal de Mycologie Médicale

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Prevalence and Antifungal Susceptibility Patterns of Yeast Isolates at the Komfo Anokye Teaching Hospital (KATH), Kumasi, Ghana

Cited by 24 publications

References 23 publications

Incidence and Speciation of Candida Species among Non-gravid young Females in Ilorin, North Central, Nigeria

Incidence and Speciation of Candida Species among Non-gravid young Females in Ilorin, North Central, Nigeria

An investigation of the distribution of Candida species in genitourinary candidiasis and pelvic inflammatory disease from three locations in Ghana

Species distribution and antifungal susceptibility of Candida spp. isolated from superficial candidiasis in outpatients in Iran

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