Prevalence and antifungal susceptibility of <i>Candida</i>
 species among pregnant women attending a school maternity at Natal, Brazil

Brandão, L.D.S.; Boniek, Douglas; Stoianoff, Maria Aparecida de Resende; Mata, F.M.R. da; Azevedo, Paulo Rm; Fernandes, José Veríssimo; Andrade, Vânia Sousa

doi:10.1111/lam.13034

Cited by 10 publications

(12 citation statements)

References 29 publications

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“…in the majority of the cases. The highest prevalence of C. albicans that had been recorded from the samples of pregnant women was 95% in Natal, Brazil [ 36 ]. Dias et al [ 34 ] also had found a prevalence of 92.3% for C. albicans in Mato Grosso, Brazil.…”

Section: Prevalence Of Vulvovaginal Candidosis During Pregnancymentioning

confidence: 99%

“…C. albicans was found to be significantly associated with gestational diabetes [ 33 ]. Nevertheless, several studies did not find any significant statistical relationship between diabetes and VVC during pregnancy [ 29 , 36 , 43 ]. Guzel et al [ 11 ] also found no association of DM with the prevalence of candida vaginitis during pregnancy.…”

Section: Risk Factors Of Vvc During Pregnancymentioning

confidence: 99%

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Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review

Disha

Haque

2022

Infectious Diseases in Obstetrics and Gynecology

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Vulvovaginal candidosis (VVC) is a symptomatic vaginal yeast infection, especially caused by Candida spp. Although VVC is common among reproductive-age women, prevalence studies notice the uprise of vaginal Candida colonization to 30% during pregnancy by culture, especially in the last trimester. Recent studies have considered it a severe problem due to the emerging evidence showing the association of VVC with a higher chance of pregnancy-related complexities (e.g., preterm labor, premature rupture of membranes, congenital cutaneous candidosis, and chorioamnionitis). In this review, we have reassessed and summarized the prevalence rate of VVC in expecting mothers and analyzed the association of several factors to the increased risk of VVC during pregnancy in different regions of the world. Altogether, these data collected from various studies showed the highest prevalence of VVC during pregnancy, mostly in Asian and African countries (90.38%, 62.2%, and 61.5% in Kenya, Nigeria, and Yemen, respectively). The prevalence rate of VVC during pregnancy was also found to differ with age, gestation period, parity, educational status, and socioeconomic level. Some pregnancy-related factors (e.g., weakened immunity; elevated level of sex hormones, glycogen deposition; low vaginal pH; decreased cell-mediated immunity) and several clinical and behavioral factors can be suggested as potential risk factors of candidosis during pregnancy.

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Section: Prevalence Of Vulvovaginal Candidosis During Pregnancymentioning

confidence: 99%

Section: Risk Factors Of Vvc During Pregnancymentioning

confidence: 99%

Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review

Disha

Haque

2022

Infectious Diseases in Obstetrics and Gynecology

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“…Among many causes of vaginitis, VVC is the second most common and is diagnosed in 40% of women with vaginal complaints in the primary care setting [6,28,29] and it is a problem that is known to affect significant number of pregnant women worldwide [30][31][32][33]. Of all Candida spp.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antifungal Susceptibility of Candida albicans Causing Vulvovaginitis Among Pregnant Women in Lebanon

Ghaddar¹,

Anastasiadis²,

Halimeh³

et al. 2019

Preprint

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Background: Vaginal candidiasis is frequently prevalent in pregnant women and is associated with sepsis and adverse neonatal outcomes. This study determined the presence of Candida species in symptomatic pregnant women and evaluated the antifungal susceptibility profile of the isolated strains. It also aimed to explore whether Candida species predicts gestational complications and adverse neonatal outcomes. Methods: A total of 258 pregnant women at 35 to 37 week of gestation participated in this study. Vaginal swabs from these patients were collected at various obstetrics and gynecology clinics in Lebanon for a period of 12 months. Candida isolates were identified at species level and antifungal susceptibility of Candida albicans to fluconazole (FCZ), amphotericin B (AMB), itraconazole (ICZ) and voriconazole (VCZ) was determined by the agar-based E-test method. Results: Among 258 women tested, 100 (39%) were positive for Candida species. C. albicans, C. glabrata and C. krusei were isolated from 42%, 41% and 17% of the women, respectively. C. albicans had significant positive associations with gestational diabetes while C. kreusi or C. glabrata had significant positive associations with gestational complications and vaginal discharge. The antifungal susceptibility tests of C. albicans isolates revealed 97.5%, 90%, 87.5% and 97.5% susceptibility to AMB, FCZ, ICZ and VCZ, respectively. . Conclusion: The current study revealed high incidence of both C. albicans and non-C. albicans strains causing vulvovaginitis among pregnant women in Beirut, Lebanon. Whereas the susceptibility rates of C. albicans against AMB and VCZ were high, FCZ and ICZ proved comparatively less efficacious. The resistance profile of circulating C. albicans among pregnant women can predict the best outcome of appropriate prophylaxis or treatment of neonatal candidiasis. Vaginal candida colonization might lead to adverse neonatal outcome or gestational complications thus Candida screening as antennal follow up is advised.

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“…All samples were obtained from the posterior fornix of the vagina with sterilized vaginal swabs and initially examined by gram stain, followed by inoculation on malt extract agar (Difco) supplemented with chloramphenicol (50 mg/ml), CHROMagar Candida medium (CHROMagar Company, Paris, France) to ensure purity, and incubated at 35-37 °C for 48 h [ 7 ]. Approval of the research was acquired from the Research Ethics Committee of the Fasa University of Medical Sciences (IR.FUMS.REC.1395.85), and written consent was obtained from all patients involved.…”

Section: Methodsmentioning

confidence: 99%

“…Several studies reported that Candida albicans is predominantly involved in VVC, followed by Candida glabrata , Candida tropicalis , Candida parapsilosis , and Pichia kudriavzevii ( Candida krusei ) [ 4 , 6 , 7 ]. Nevertheless, the increasing prevalence of non- albicans Candida species with a reduced susceptibility acquired resistance or intrinsic resistance to the antifungal drugs currently administered has become the most important issue of treatment failure, over the past decade [ 4 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Candida species isolated from vulvovaginal candidiasis by MALDI-TOF with in vitro antifungal susceptibility profiles

Aslani¹,

Kokabi²,

Moradi³

et al. 2022

CMM

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Background and Purpose: Vulvovaginal candidiasis (VVC) is an opportunistic infection due to Candida species, one of the most common genital tract diseases among reproductive-age women. The present study aimed to investigate the prevalence of VVC among non-pregnant women and identify the epidemiology of the involved Candida species with the evaluation of antifungal susceptibilities. Materials and Methods: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) was performed to identify Candida species isolated from the genital tract of 350 non-pregnant women. Moreover, antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method guidelines (M27-A3 and M27-S4). Results: Vaginal swab cultures of 119 (34%) women yielded Candida species. Candida albicans was the most frequently isolated species (68%), followed by Candida glabrata (19.2%). Voriconazole was the most active drug against all tested isolates showing an MIC50/MIC90 corresponding to 0.016/0.25 µg/mL, followed by posaconazole (0.031/1 µg/mL). Overall, resistance rates to fluconazole, itraconazole, and voriconazole were2.4%, 4.8% and, 0.8% respectively. However, posaconazole showed potent in vitro activity against all tested isolates. Conclusion: Results of the current study showed that for the effectual therapeutic outcome of candidiasis, accurate identification of species, appropriate source control, suitable antifungal regimens, and improved antifungal stewardship are highly recommended for the management and treatment of infection with Candida, like VVC.

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Prevalence and antifungal susceptibility of Candida species among pregnant women attending a school maternity at Natal, Brazil

Cited by 10 publications

References 29 publications

Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review

Prevalence and Risk Factors of Vulvovaginal Candidosis during Pregnancy: A Review

Prevalence and Antifungal Susceptibility of Candida albicans Causing Vulvovaginitis Among Pregnant Women in Lebanon

Characterization of Candida species isolated from vulvovaginal candidiasis by MALDI-TOF with in vitro antifungal susceptibility profiles

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