Prevalence and Antibiotic Resistance Pattern of <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i> in Urine Tract Infections at the La Paz Medical Center, Malabo, Equatorial Guinea

Abstract

The study was conducted to isolate and determine the antibiotic resistance in Escherichia coli and Klebsiella pneumonia from urine samples over a 2-year period (August 2013-September 2015) at the La Paz Medical Center, Malabo. A retrospective analysis of 785 urine culture samples over a 2-year period August 2013-September 2015 was carried out according to the routine protocol of urinalysis. Bacterial etiological agents were isolated from 155 (19.7%) samples with highest prevalence of Escherichia coli (55.5%) followed by Klebsiella pneumonia (23.2%), Proteus mirabilis (4.5%), Pseudomonas species (3.2%), Enterobacter species (2.6%), Enterococcus faecalis (2.6%) and others species (8.4%). The E. coli and K. pneumonia represent 78.7% of all isolated bacterial strains. The E. coli and K. pneumoniae isolates possess highly resistant to ampicillin, Trimethoprim/Sulfamethoxazole, Doxycycline, Amoxicicline/Clavulanic acid. Whereas K. pneumonia demonstrated also to be highly resistant to Gentamycin, Cefuroxime and Ceftriaxon, low level of resistance to Piperacilin/Tazobactam, Amikacin and the lowest to Imipenem. The alarming level of MDR strains to the first choice antibiotics treatment was observed.

Antibiotic resistance pattern of Escherichia coli isolates from outpatients with urinary tract infections in Somalia

“…The study findings likely indicate a high prevalence of UTI among study participants 67.2% (n = 82/122), as this was also reported in a similar study [11]. The risk of UTI among outpatients with the previous history of UTI, history of antibiotic use and having symptoms of UTI were significantly higher than those without a previous history of UTI and antibiotic use; and not having symptoms of UTI., These could indicate there are an association between former variables and urinary tract infections as indicated by other studies [1,12,13]. This could be related to the overuse of antibiotics without microbiological investigations since most clinicians depend on empirical therapy as the first decision or even selfprescription of antibiotics by the patients.…”

“…Urinary tract infection (UTI) mainly results from the colonization of microorganisms in the genitourinary system [1]. It is a serious public health problem in developing countries, as encountered in both hospital and community settings, causing significant morbidity and mortality [2].…”

“…It is a serious public health problem in developing countries, as encountered in both hospital and community settings, causing significant morbidity and mortality [2]. The factors associated with the high prevalence of UTI within the population include age, gender, sexual activity, contraceptive use, previous history of UTI, indwelling catheter equipment and hygiene problems [1,3,4]. Amongst the uropathogenic bacteria known to cause urinary tract infection, Escherichia coli is the predominant bacteria in both community and hospital environments [1,5,6].…”

“…The factors associated with the high prevalence of UTI within the population include age, gender, sexual activity, contraceptive use, previous history of UTI, indwelling catheter equipment and hygiene problems [1,3,4]. Amongst the uropathogenic bacteria known to cause urinary tract infection, Escherichia coli is the predominant bacteria in both community and hospital environments [1,5,6]. However, the diversity of bacterial uropathogens that cause UTI varies geographically [5,7].…”

Physico-Chemical and Microbiological Analysis of Water of the “Presa De Los Patos” in the Desierto De Los Leones National Park, Mexico

“…The middle zone and the low zone presented values much higher than those es- [46]. There are a number of ways by which microorganisms are resistant to antimicrobial agents.…”