Prevalence and alteration in haematological parameters of glucose-6-phosphate dehydrogenase deficient Proto-Australoid population of Malaria endemic Himalayan belt of Assam, India

Basumatary, Noymi; Baruah, Dipankar; Sarma, Paresh Kumar; Deka, Manab; Sarmah, Jatin

doi:10.52635/eamr/11.1.43-48

Cited by 3 publications

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“…Consequently, the platelet count may be lower in G6PD-deficient individuals compared to G6PD-normal individuals. Some studies have found that G6PD deficiency without evidence of hemolysis is associated with a lower platelet count than G6PD-normal [ 17 - 19 ], but other studies have not found such an association [ 20 , 21 ]. Thus, we conducted this study to assess whether platelet count is higher in the O-B incompatible neonates versus (vs) the O-A incompatible neonates and whether it correlates with their G6PD levels.…”

Section: Introductionmentioning

confidence: 99%

Cord Platelet Count of Full-Term Neonates in Relation to ABO Incompatibility and Glucose-6-Phosphate Dehydrogenase Levels: A Retrospective Cohort Study

Al-Abdi¹,

Al-Omran²,

Shapan³

2022

Cureus

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BackgroundThe immunoglobulin G of mothers with O blood type may sensitize the platelets of their neonates with A (O-A incompatibility) or B (O-B incompatibility) blood type. As the expression and antigenicity of the B antigen on platelets is less than that of the A antigens, we have hypothesized that platelet count is higher in the O-B incompatibility group compared to the O-A incompatibility group. There is controversy about whether glucose-6-phosphate dehydrogenase (G6PD) deficiency, without evidence of hemolysis, is associated with a lower platelet count than G6PD-normal. AimTo assess whether platelet count is higher in the O-B than in the O-A incompatible neonates and whether it correlates with their G6PD levels. MethodsThis study was a retrospective cohort study on a sample of 835 healthy neonates born at ≥38 weeks gestation who were either A or B blood types with mothers that carried the blood type O Rh-positive. The platelet count (thousand per microliter) from umbilical cord venous blood (UCVB) was used. A G6PD level of 11.0 units/gram of hemoglobin (U/g Hb) was considered the lower reference limit. G6PD deficiency was defined as a G6PD level of <3.3 U/g Hb in both sexes. Intermediate G6PD deficiency in females was described as a G6PD level of 3.3-8.8 U/g Hb. ResultsThe mean UCVB platelet count was higher in female neonates compared to male neonates (n=389, 283±65 versus n=446, 272±73, p=0.01). The mean UCVB platelet count was higher in the O-B incompatibility group in both male (n=114, 291±82 versus n=103, 266±63) and female neonates (n=83, 303±66 versus n=81, 278±58) with G6PD levels of >8.8 U/g Hb. There was a positive weak correlation between UCVB platelet counts and G6PD levels only in O-B incompatible female neonates (n=176, r=0.23, p=0.002). The partitioning and combined 95% reference intervals (RIs) of the UCVB platelet count were presented. ConclusionThe platelet count was higher in the O-B incompatibility group compared to the O-A incompatibility group, but only when the G6PD level was >8.8 U/g Hb. A correlation between UCVB platelet count and G6PD levels was found only among O-B incompatible female neonates. These findings may have an important implication in estimating RIs of the UCVB platelet count, however, they need to be confirmed and explored in future research.

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Section: Introductionmentioning

confidence: 99%

Cord Platelet Count of Full-Term Neonates in Relation to ABO Incompatibility and Glucose-6-Phosphate Dehydrogenase Levels: A Retrospective Cohort Study

Al-Abdi¹,

Al-Omran²,

Shapan³

2022

Cureus

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Identification of glucose-6-phosphate dehydrogenase variants by utilizing polymerase chain reaction – Restriction fragment length polymorphism based method

Basumatary,

Baruah,

Sarma

et al. 2024

Gene Reports

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A Case Report of Co-occurrence of Hemoglobinopathy EE and Glucose-6-phosphate Dehydrogenase A+ Variant

Basumatary,

Baruah,

Sarma

et al. 2023

Biomedical and Biotechnology Research Journal (BBRJ)

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Hemoglobinopathies and glucose-6-phosphate dehydrogenase (G6PD) deficiency are two genetic disorders prevalent in malaria-endemic regions. There are conflicting reports on the co-occurrence of G6PD deficiency and hemoglobinopathies. The present study was conducted to explore the co-occurrence (if any) of the two disorders among ethnic populations of Proto-Australoid and Mongoloid origin races. Out of 2310 subjects screened, only one case was detected with both disorders. The case described here is an asymptomatic female of 52 years detected with both hemoglobinopathy EE (HbEE) and G6PD A+ variant. Lower levels of hemoglobin (Hb) %, mean corpuscular hemoglobin (MCH), MCH concentration, platelets, and white blood cell count, and high red cell distribution width and fetal Hb% were recorded. Family screening revealed both daughters as HbAE and normal G6PD. The husband had HbAA and normal G6PD. Out of six siblings of the case subject, two were detected as HbEE and four as HbAE; G6PD was normal.

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Prevalence and alteration in haematological parameters of glucose-6-phosphate dehydrogenase deficient Proto-Australoid population of Malaria endemic Himalayan belt of Assam, India

Cited by 3 publications

References 0 publications

Cord Platelet Count of Full-Term Neonates in Relation to ABO Incompatibility and Glucose-6-Phosphate Dehydrogenase Levels: A Retrospective Cohort Study

Cord Platelet Count of Full-Term Neonates in Relation to ABO Incompatibility and Glucose-6-Phosphate Dehydrogenase Levels: A Retrospective Cohort Study

Identification of glucose-6-phosphate dehydrogenase variants by utilizing polymerase chain reaction – Restriction fragment length polymorphism based method

A Case Report of Co-occurrence of Hemoglobinopathy EE and Glucose-6-phosphate Dehydrogenase A+ Variant

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